Excerpts

We report the fraction of Bonferroni replicated pQTMs at 95% replication power and the fraction of nominally significant pQTMs with consistent directionality within all nominally significant pQTMs for all steps (Supplementary Data 3 ).

However, when assessing neuronal activation in the granule cell layer of the DG during memory retrieval we found that 4D-treated mice displayed a clear trend of decreased density of c-Fos+ cells relative to controls (4D vs.

MAIT cell production of cytokines in response to bacterial stimulation were rather stable during the first three time points evaluated, and showed a trend towards decline at the final time point corresponding to early chronic HIV-1 infection (Fig. 6b ).

In contrast, the equilibrium potential for OER exhibits a decreasing trend with a slope of −59 mV pH −1 , starting from U SHE (theoretical SHE potential) = 1.23 V and pH = 0 (ref. 60 ).

Deep sequencing analysis from the clindamycin selection reveals a densely connected network of winning genotypes, which display an overall trend of positive epistasis, suggesting the importance of epistatic interactions in evolving ribosome function.

Our results also show a decreasing trend in rice paddy area in monsoon Asia since 2007, which suggests that the change in rice paddy area could not be one of the major drivers for the renewed XCH 4 growth, thus other sources and sinks should be further investigated.

The interannual variations in XCH 4 in the rice paddy-dominated areas of monsoon Asia, China, and India were relatively stable during 2003–2006, but changed into an increasing trend beginning in 2007 (Fig. 5 ), which agreed well with the trends of global XCH 4 1 .

5a ) and a highly significant correlation with EF improvement proofing a strong PK/PD relationship (Fig. 5b ; Supplementary Fig. 5a, c ).

Consistent with higher expression values previously associated with essential genes 15 , we show a decreasing trend in human gene expression levels from most to least essential FUSIL bins, as measured by median GTEx expression across a wide range of tissues and cell lines (Fig. 2b ).

With this stringent filter based on minimum absolute number of sampled species and consistently high global taxonomic coverage, the correlations between genetic and species diversity increase and the significance of the main parameters remains nearly significant (Supplementary Table 7 ).

Immunoblots of ProSPC and vWF lung protein levels showed an increasing trend in the secretome treated groups compared to the PBS group (Fig. 2e, f ).

LSC-secretome treated groups showed a decreasing trend in αSMA when compared to PBS treated controls.

The mutation loads of these sets show highly significant, positive correlations with the loads of driver mutations across tumors in the respective class (Fig. 2b , which is not observed for most of the randomly chosen sets of mutation; Supplementary Fig. 7 ).

Much more surprising was the highly significant, approximately 2-fold increase in fully saturated lipids resulting from PUFA supplementation (Fig. 2a ), due to the significantly increased abundance of phospholipid-incorporated saturated fatty acids (Fig. 2a , inset).

Furthermore, we could observe a highly significant positive correlation between the peak serum type I IFN levels elicited by different viral infections and the frequencies of Vβ5 + iTreg cells (Fig. 1g and Supplementary Fig. 2d ).

The pairwise correlations between allele effect size estimates in the different cohorts were all highly significant, ranging from 0.44 between QIMR and UKBR and 0.91 between UKB and SUNLIGHT.

GWAS analysis of regulatory or functional information enrichment with LD correction (GARFIELD) revealed highly significant 3 to 4-fold enrichment of asthma-associated variants colocalizing to DNase I hypersensitive sites in several tissues with biological relevance to asthma, such as epithelium, lung, and thymus (Fig. 4a ; Supplementary Data 10 ).

Our analysis demonstrated a clear trend toward increased IRES reporter activity in muscles of our transgenic mice overexpressing eEF1A2 (Fig. 1c ).

In cases where these described issues may be significant, BisqueMarker provides cell-type abundance estimations using only known marker genes.

This is possibly why we observed a markedly significant difference between ILAE3–6 patients’ spike and seizure analysis while no such difference was observed among ILAE 1 and 2 patients in the two groups.

Integration of DMG and DEG datasets showed a trend of differential methylation within genes functioning upstream in the pathway (Fig. 6c ), and a significant proportion (37.3–40.8%) of the 1982 genes that interact with CCA1/TOC1 differentially expressed in msh1 memory (Supplementary Fig. 7b ), reflecting sizeable enrichment.

In general, morphologies n409 and n127 showed a trend for some cells with deep-like traits (firing towards the peak) versus n128 and sup1 (a superficial cell reconstructed in our lab) with more consistent superficial-like firing (around the trough) (Fig. 2g ).

Two other neuroimaging phenotypes showed nominally significant effects on depression, including higher MD in the ATR for MR-Egger (tMD-ATR; β = 0.107, p for MR-Egger = 0.028, p FDR = 0.166; however, the Egger intercept was not significant, p FDR = 0.432, Supplementary Fig. 11 , Supplementary Data 6 and Supplementary Table 3 ) and ICVF in SLF (tICVF-SLF; β = −0.025, p = 0.030, p FDR = 0.179 for IVW).

Numerous highly significant interactions were inferred between mo-Macs and aggressive/metastatic tumor cells involving the activation of TNF, TGF-β, and EGFR signaling pathways in tumor cells; these interactions may induce ERK-MAPK signaling, invasive mesenchymal phenotypes, and tumor growth.

In most cancer types we observed a negative trend between gHFI burden and age except in glioblastoma, urothelial bladder carcinoma, and stomach adenocarcinoma.