Excerpts

The miRNA identified as positively and negatively associated with the hallmarks gene signatures in this dataset showed highly significant concordance, over the majority of signatures, with the results obtained in analysis of the TCGA BRCA dataset (Supplementary Figure 12 , Supplementary Note 5a ).

We mapped cis-QTL with QTLtools 1.3 39 to obtain (1) the top cis-QTL association for each gene after empirically adjusting p values using 1000 permutations, (2) all nominally significant associations, and (3) conditional cis-QTL associations after stepwise regressing out stronger, masking cis-QTL signals from the gene expression measurements.

All three species are strongly positively sensitive to winter precipitation, with a significant trend towards greater sensitivity in the south and east.

A one-sample t- test was performed on the fitted slopes resulting from the regression of rotation magnitude and movement angle to test for the presence of a reliable trend.

Linear regressions were performed on subjects’ full distribution (i.e., no binning) of reach angles and RTs after the critical RT bin, and a t- test was performed on the resulting slopes to test for the presence of a significant trend.

Complementary loss-of-function approaches validated the specificity of the Ddr dn -induced phenotype, as lineage-specific RNAi using short hairpin microRNA (shmiR) constructs showed a trend suggesting synergy with low doses of Ddr dn to cause a penetrant de-adhesion phenotype (Supplementary Figure 4 ).

For males, significant positive trends with increasing quartiles of WHR were observed for the incidence of all-cancer ( P trend = 0.01, Cox proportional hazard), prostate cancer ( P trend ≤ 0.01, Cox proportional hazard), and a marginally statistically significant positive trend was observed for colon cancer ( P trend = 0.06, Cox proportional hazard).

We can summarize these results by asking: What is the percentage of the ocean area showing a significant trend at different intervals over the 21st century?

Where some of the reflectance bands do not show a strong trend, they will dampen the signal of the change in true colour.

l-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY issue-copyright-statement © The Author(s) 2019 Introduction Tropical cyclones (TCs) are one of the most costly natural hazards impacting on coastal regions across the world 1 – 3 and there is an increasing trend of TC related billion-dollar disasters in the US 4 .

In contrast, compound 1 did not show a clear trend (Supplementary Fig. 4 ).

Interestingly, the correlation between bypassability and differential essentiality remained highly significant after gene importance was controlled for (Supplementary Fig. 2k ).

In the mixed effects model, this result was marginally significant in PRc and nonsignificant in PHc and should be interpreted with caution.

Compared to WT mice, Lmo7 exon17 KO mice showed a highly significant reduction in gentamicin immunoreactivity, in both inner and outer hair cells (Fig. 7c, d ).

The effect of chloride ions on the fructose conversion reaction rate relative to H 2 SO 4 has an increasing trend with increasing concentrations of GVL in the solvent system.

The levels of another adipogenic transcription factor PPAR gamma was also evaluated, which was consistently higher but did not quite reach statistical significance in ING3 and EPDR1 targeted cells (Fig. 3d ).

5d ), whereas DA2 showed a trend toward inhibition of the interaction (Supplementary Fig. 7A ).

3d ) and a non-parametric analysis of variance showed this effect to be highly significant across all mouse populations tested.

The high proportion of branch neoantigens was associated with short overall survival in a marginal significance, which was probably due to the insufficient sample size (Fig. 7d ).

Discussion The results presented here indicate that analyses of the number of people exposed to flooding undertaken with existing population data sets may be significant overestimates.

GSEA with these CIZ1-dependent transcription units also revealed highly significant overlap with genes regulated by PRC1 and PRC2 (Fig. 3a , Supplementary data 2 , tab 1 ), though unlike culture-adapted cells there was little change in PRC subunit transcript levels (Supplementary Fig. 2 ), and also no gross change in the overall immuno-staining pattern for SUZ12, RING1B or BMI1 in primary cells (Supplementary Fig. 2 ).

The difference in CDI between ORAI1 and ORAI1β, which was highly significant when CRAC currents were activated by including 10 mM of the slow buffer EGTA in the pipette (Fig. 1b–d ) disappeared when CRAC currents were activated by dialysis of 20 mM of the fast chelator BAPTA through the pipette (Fig. 1e–g ) or when extracellular Ca 2+ was replaced by Ba 2+ (Fig. 1h–j ), strongly arguing that this difference in CDI is mediated by cytosolic Ca 2+ at the vicinity of ORAI1 channels.

We then compared the breakpoint junctions between TDP and non-TDP types and three span-size categories, finding the borderline significance according to microhomology patterns (Supplementary Fig. 9D ).

However, while multiple nominally significant cis -eQTLs were present, nearly half of all loci had no evidence of cis -eQTLs in the sample sets used.

Clearly, R Ω , the resistance of the solution and electrode, presented a slightly increasing trend from 10.8 to 17.5 Ω/cm 2 under the potential of 1.2 to 1.6 V; meanwhile, the R ct, the charge transfer resistance, gave a decreasing trend from 277.4 to 168.6 Ω/cm 2 .