Excerpts

These correlations were significant for discriminability, but not reliability, and the relationship between LDA accuracy and performance approached significance (Fig. 3a–c bottom).

Gene enrichment analysis using the top distinguishing genes of this cluster identified highly significant biological functions associated with vasculature and connective tissue, including genes encoding collagens and other extracellular components (Fig. 2f , Supplementary Fig. 6a , Supplementary Data 3 ).

The requirement for Pir2 in mediating the repressive effects of lncRNAs is a highly significant finding.

Compared to NF-co-culture, imCMs co-cultured with AFs exhibited a decreasing trend in action potential duration to 50% repolarization (APD50) and to 90% repolarization (APD90), respectively, while beating frequencies remained similar (Fig. 4g–j ).

At the same time, there is a strong trend towards a greater number of shorter high-capacity links.

When we used gene set enrichment analysis to compare differentially expressed genes in E6.5 Blimp1 mutants with predicted progesterone and oestrogen responsive genes (based on proximal PR and Esr1 binding) we observed a highly significant correlation (FDR q -value > 0.0001) between downregulated genes in Blimp1 mutant decidua and progesterone receptor target genes (Fig. 4d ).

We tested these genes on an independent dataset of 4,877 cases and 6,203 controls, HIST1H1E showed nominally significant (Supplementary Table 3 ).

8a ; iWAT and BAT showed a trend toward increased cAMP levels).

As expected, the mixed model confirmed that TSR frequencies were also highly significant as predictors of herbicide resistance (Supplementary Table 2 ).

Therefore, both these analyses suggested an overall trend toward increasing precipitation variability along with decreasing evaporation variability, reinforcing our main conclusions.

Pathway-level methods were also more robust against batch effects, thus enabling the aggregation of data from various cohorts, resulting in highly significant biomarkers 18 – 22 .

However, using the PathOlogist activity scores, we identified 9 significant ( q ≤ 0.05) and 31 near-significant (0.05 < q ≤ 0.25) pathways in both microarray and RNA-seq datasets.

TF13 asks by what time two differently forced simulations of annual mean surface temperature differ by more than the internal variability, and quantify emergence as the time when a significant trend can be found in the difference between two simulations.

Besides, we observed a highly significant correlation and concordance between the identity of the rearranged IGHV gene sequences obtained by IgCaller and SSeq/NGS.

While there is no obvious change for V oc (~5.5 V, 269.9 V/cm 3 ) and Q sc (~1.6 nC, 78.5 nC/cm 3 ), the peak value of short-circuit current ( I sc ) reveals an increasing trend with the frequency, from ~90 nA (4.4 μA/cm 3 ) at 1 Hz to ~180 nA (8.8 μA/cm 3 ) at 4 Hz.

Antibody responses against oncogenic pathway proteins Due to the intense lymphodepleting chemotherapy administered prior to CAR T-cell infusions, we monitored the immunoglobulin (IgG) levels in this child which paradoxically showed an increasing trend during induction (Fig. 6a ).

Each test yielded a p value which allowed us to sort features from smallest (most likely to be significant) to largest (least likely).

We also performed a gene-annotation enrichment analysis using g:Profiler 17 , 18 , and found highly significant enrichments in several gene-annotations associated with the cell surface, including the terms plasma membrane and cell periphery (Fig. 1d, e ).

Since Model 1 is a submodel of Model 2, we also compared both models by using Akaike’s Information Criterion (AIC) 32 , which penalizes more complex models, resulting in a highly significant preference for Model 2 (Supplementary Note 1 ).

However, these putative elusive cancer genes did often displayed a tendency towards significance in the MutSig2CV analysis, likely reflecting a limitation of the cohort size (Supplementary Fig. 16 ).

We observed a decreasing trend of branching ratios for the set of standards, uraninite for U(IV), UMoO 5 for U(V) and UO 3 for U(VI), from 0.6956, 0.6887 to 0.6640 (median values from 10–13 measurements), providing a reliable reference set to resolve U valence states (Fig. 7 ; Supplementary Table 3 ).

We observed a highly significant increase in erythroid colony-forming cells (Fig. 3d ), and a corresponding decrease in myeloid colony-forming cells (Fig. 3e ).

The evolution of stacked seismic power early in the slip cycle is characterized by a decreasing trend in both Cascadia and the laboratory.

A positive trend in the Southern Annular Mode (SAM) is associated with a strengthening and poleward shift of the Southern Ocean westerly winds 39 , which is projected to persist due to continued anthropogenic forcing 40 , 41 .

Patients carrying both ELF3 and TP53 mutations had a worse overall survival that showed a trend towards significance ( p value 0.0547; Fig. 2f ) as opposed to no difference in survival in individuals with mutations in just either one of the genes (Supplementary Fig. 8d ).