Barely Significant

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Concerning lipid metabolism, D patients had significantly higher triglycerides (at T1 p < 0.001, at T6 p = 0.002, at T12 p < 0.001) and total cholesterol (at T6 p = 0.004, at T12 p = 0.009) than the ND group as well as a significant reduction in HDL cholesterol at T12 ( p = 0.020); markers of lipid metabolism showed a decreasing trend in both groups during observation ( Figure 2 and Table S3 ).
[ 49 ], a slight trend towards an improvement in the glare sensitivity (mainly at medium frequencies) was observed from the first to the third month of supplementation (20 mg/day), and only after six months of lutein supplementation was a significant change observed in healthy subjects.
Perceived Stress and Anxiety As shown in Table 5 , PSS total scores showed a decreasing trend over the study period, which was of greater magnitude in the experimental group (mean decrease of 9.1 points) as compared with the placebo group (mean decrease 5.8 points), although between-group differences were not statistically significant.
This was ascribed to the fact that the mean scores for the above factors reduced at first in both diet groups, then afterwards showed a trend of staying modest in the HCLF group and, over time, returned to near the initial levels in the very LCHF group [ 39 ].
The findings from the cohort studies in this review on the impact of broccoli consumption on the risk of reproductive cancer [ 59 , 62 ] are consistent with the results reported by Hu et al., 2015, who observed a 22% reduction in the risk of ovarian cancer with marginal significance for broccoli (RR: 0.78; 95% CI 0.58 to 1.06) [ 18 ].