Barely Significant

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There were no significant differences in total mitochondria counted ( Table 1 , VC), and the mean diameter of presynaptic terminal mitochondria was similar between control and Pb 2+ -exposed groups ( Table 1 , VD), although there was a nearly significant increase in the number of mitochondria with diameter greater than 300 nm ( Table 1 , VD).
Although there were no significant differences in the levels of aggrecan and collagen II across the various conditions, we found a decreasing trend in the expression level of Mmp13 mRNA in chondrocytes treated with CM from FSS NNC and static NNC vs . chondrocytes treated with CM from FSS UT ( Fig 4 ).