Barely Significant

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However, our findings contradicted a study, which reported that the expression levels of FUBP1 protein and the clinicopathological characteristics were not correlated despite the highly significant association between high levels of FUBP1 protein and high tumor cell proliferation rates (ki-67) [ 35 ].
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When a more stringent cut-off value of |r| > 0.92 was applied, 9 molecular descriptors were found to be correlated with OCT1 activity inhibition ( S4 Table ); linear regression analysis next confirmed a highly significant linear relation between the index values of these descriptors and the percentages of OCT1 activity inhibition ( S8 Fig ).
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We argue that pseudoreplication is unlikely to be associated with confounded effects as 1) we have accounted for such issues in our statistical analysis, by using an appropriate multilevel model (GLMM) [ 61 ]; 2) we have maintained very high standards of water quality, which made sure there were no other differences in the seawater between treatments, other than carbonate chemistry, that could be responsible for the differences observed; and 3) our results are highly significant, and consistent with other studies [ 38 , 39 , 40 ], which provides a degree of replication on its own.