Excerpts

However, retinoids are also teratogens, and there may be significant benefit obtained using ligands with defined and limited receptor specificity (reviewed in [12] ).

When CD40 (rs6074022) results were stratified by sex, there was a weak trend towards a stronger effect in males than females (coefficients −3.1247 and −1.1795 respectively), and a weak trend towards a stronger effect in HLA-DR15 negative individuals than HLA-DR15 positive individuals (coefficients −1.8818, and −0.9834 respectively), but these trends were not significant (interaction p-values 0.475 and 0.224, respectively) ( Table 4 ).

Also, the weighted degree values of lung cancer and head and neck cancer are close to being significant.

Therefore, given the number of statistical tests performed, some of the associations reported, particularly borderline significant, could be spurious.

There was an increasing trend in CXCL8-stimulated association of LASP-1 with CXCR2 over time in dHL-60 cells.

GSEA showed that there was highly significant enrichment of psoriasis DEGs, both up- and down-regulated genes, from the three studies compared to our data ( Table 4 ).

There was a numerical trend towards increased F4/80+CD11b+ macrophages/monocytes in the spleen and blood on days 2 and 7, respectively, though these data were not statistically significant.

The mAbs showed a trend toward better potency against psVs with chronic Envs (AUC = 0.12 to 0.54; median = 0.30) than against acute Envs (AUC = 0.10 to 0.46; median = 0.23); this difference did not reach statistical significance.

WHR and two skin fold measures (TrS and SbS) of cluster 2 also showed nominally significant associations with some of these markers, significance of which were not supported by the permutation test.

Presence of BCG scar showed a trend to association (OR 1.52; 95% C.I. 0.96–2.41).

With the restrictive time window 2 borderline significant cluster-signals were detected, that had been non-significant in the initial analysis.

However, evaluation of telomere lengths of DNA samples of following generations of TERT mutations has shown a statistical trend toward further telomere shortening for three large kindreds.

Genetic controls also showed a significant increase in the courtship index at elevated temperatures ( Fig 2, Ci ), but if anything, flies with lowered DA- and 5HT-neuron function showed a trend towards a decrease in the courtship index at the restrictive temperature (the value did not reach significance in this set of experiments).

This category approached significance for overrepresentation and contained 4 additional genes from the CaRF ChIP list whose products regulate protein ubiquitination, SUMOylation, and sulfonation.

There was an increasing trend from 1973–1997 in dissolved chloride and copper [39] .

Methodology/Principal Findings The interpretation of sterol distribution data in a modern phylogenetic context indicates that there is a clear trend from cholesterol and other Δ 5 sterols in the earliest diverging fungal species to ergosterol in later diverging fungi.

A clear trend towards an up-regulation of chemokines involved in attraction of Th1 cells ( Cxcl9 , Cxcl10 and Cxcl11 ) and/or monocytes/macrophages ( Ccl3 , Ccl4 , Ccl7 and Ccl12 ) upon stimulation with L. acidophilus NCFM emerged, whereas B. bifidum Z9 gave rise to a much lower gene induction of Th1 recruiting chemokines (55% reduction of Cxcl9 , 44% reduction of Cxcl10 and 73% reduction of Cxcl11 compared to DC stimulated with L. acidophilus NCFM ).

[6] , [7] , [8] Therefore, the statistical power of this analysis is small and the primary endpoint, TVR, did not quite reach statistical significance.

We have to acknowledge that even our pooled analysis is very limited in statistical power and the results showed only a borderline significance for TVR.

This characterization of the first component generalizes to all words of the dictionary, demonstrating a highly significant correlation both between corpora (MS and WN) and with the ANEW ‘pleasure’ scale ( Figure 3 ).

Otherwise, we observed a highly significant, positive correlation between the volume of enteral feeding (mL/Kg/day) and f-calprotectin excretion in multivariate analysis, as previously reported [16] .

Three moderately significant SNPs were identified on chromosome 12 at positions 69663832, 69599639 and 68553182 with p-values of 1.04 e-06, 1.44 e-06 and 1.50 e-05 and explained 0.48% 0.46% and 0.38% of the phenotypic variance respectively ( Table 1 ).

There was a highly significant change in self-reported visual analogue scores (VAS) for hunger over the eight measured timepoints, before and after the meal, and across subjects (two-way repeated measures ANOVA (week, timepoint), main effect of timepoint: F(7,126) = 266, p<0.001).

2B, C, and D , we find that there is no significant difference in mean between “Loss” and “Not Win” outcomes, while the values of and are highly significant ( ).

P values ≤0.05 were considered significant, while P values ≤0.01 were considered highly significant.