Excerpts

In our samples, we showed an increase of 3-hydroxybutyrate in MOC with a borderline significant increase in EOC.

The gene expression profile of Abca1 showed a trend similar to that of the Lxr s, but a significant reduction was only observed during long-term infection ( Fig. 5E ).

All differences between spikes and LFPs are highly significant.

In Iguhu, a decreasing trend in P. falciparum prevalence was observed from 2002 with a notable decline in 2005; however, a sharp declining trend occurred after June 2006 ( Fig. 1 ).

It is interesting to note that the mean malaria parasite density in infected volunteers exhibited an increasing trend from 2007 to 2009 and fluctuated in 2010 in Kombewa ( Fig. 2A ) and Iguhu ( Fig. 2B ).

Lastly, Dehalogenimonas was considered to have a highly significant difference when using the t-test (due to the non-normal distribution), non-significance using the Wilcoxon (likely due the high number of tied ranks) and a marginal significance using the two-part test.

This effect was significant in V2 and V3, and the negative correlations approached significance in V1.

The increase in FC is most pronounced and highly significant (p = <0.0001) for both 3TC and FTC and for both subtype backbones.

Thus protection conferred by maraviroc gel against HIV-1 vaginal challenge is highly significant (p value 0.0006, Fisher's exact test).

Furthermore, we found a near-significant inverse association between ΔWSDSbirth to 3 months and insulin sensitivity (SI derived from IVGTT) and a near-significant positive association between ΔWSDS birth to 3 months and fat mass ( Table 2 ).

P -values were not adjusted for multiple hypothesis testing and p <0.05 was considered nominally significant.

It is likely that several relevant gene categories may have been missed in our analyses mainly because elevated dN/dS ratios may be confined to a functionally highly significant region of the gene that is nevertheless too short to impart a higher than average global dN/dS ratio to the entire gene.

The majority of genes within the highly significant GO term groups were up-regulated by both adjuvants for at least one time point.

However, citalopram and reboxetine induced a strong and highly significant increase in the phosphorylation of the immaturely glycosylated form of TrkB in p CPA and DSP4 treated mice, respectively ( Figure 5B ).

Overall, highly significant differences were observed between several of the groups for specific miRNAs using a Bonferroni corrected p-value threshold for significance (6.8×10 −5 ).

GABA concentrations were significantly higher in LRRK2+/− neuronal cultures compared to wildtype controls (82.0±3.3 versus 58.3±2.8 nmol/g protein, LRRK2-deficient versus wildtype cultures, mean ± SD, n = 3 each), and glutamate concentrations showed a trend towards an increase (9.5±0.8 versus 8.5±0.1 μmol/g protein).

The corresponding p-values were highly significant, at 4.10 −19 (Yap1p bTM in S. cerevisiae ) and 1.10 −18 (Cap1p bTM in C. albicans ).

But curiously enough, adjuvant endocrine therapy including tamoxifen and aromatase inhibitors brought about a definite and highly significant decrease in the incidence of contralateral breast cancer for women with estrogen receptor (ER)-positive or ER-unknown disease [2] , [29] – [31] .

reported a statistically highly significant correlation of high expression of Gal-3 in the primary tumors with reduced metastatic potential and increased post-operative survival [42] .

For instance, equivalently silenced miRNAs in normal and cancer may be significant for cancer in a tissue-specific manner.

M402 monotherapy showed a trend towards improved survival, but did not reach statistical significance in this study (p = 0.10 by Log-Rank test).

In the extension analyses, ERK rs5999749, Dock180 rs4635002 and C3G rs7853122 showed marginally significant gene-dose effects for gastric cancer.

There was a statistical trend of increased costs in the dyads of II trials with respect to invalid trials preceded by valid trials (VI).

Additionally, there was an increasing trend in intracellular concentrations of P and S in exponential phase cultures exposed to Cu(II) relative to the control, for Cu(II) doses of 5 μM and 10 μM ( Table 1 ).

Again a highly significant loss of IFN-γ-dependent control of parasite proliferation was seen in the K-Irga6 −/− cells compared with the K-C57BL/6 wild-type cells ( Figure 5B ).