Excerpts

Transepithelial translocation experiments demonstrated highly significant effects against L. monocytogenes : Lbp LAP reduced L. monocytogenes translocation by 15.3%, 31.8%, 36.8%, and 46.3% in 1, 4, 15, and 24 h, respectively ( Fig 6c ), whereas Lbp WT had no significant effect.

The defined cut off values have been based on previous cohort data which identified patients with moderate to severe proteinuria at greater risk of poor renal outcome [22] , [24] and so we require all patients with a UACR between 100–200 mg/mmol with an increasing trend and those with a UACR>200 mg/mmol to immediately exit from the pathway for further investigation and management in liaison with a paediatric nephrologist.

At the 96 hour time point, there was a highly significant increase in E2-inducible proliferation of ECC-1 cells treated with siARNT, compared to scrambled control treated cells.

From samples from the symptomatic study a significant trend for increased and earlier failure was seen with those carrying the 581G mutation prior to treatment ( Figure 4 ).

pylori infection and smoking tended towards significance ( P for interaction = 0.080).

Values of p <0.05 were considered significant ( * ) while values of p <0.01 and p <0.001 were defined very significant ( ** ) and extremely significant ( *** ), respectively.

As mentioned above, the total number of γδ IELs tended to be increased despite a highly significant decrease of the total number of CD3 + IEL/U in the HIV + patients as a group (medians 31.7–45.7/U) compared with healthy controls ( Fig. 4 ).

Once again the highly significant treatment effects demonstrated that saliva treated plants had a greater compensation response than untreated plants ( Table 3 , Fig. 2 ).

The orientation of the CTCF/H2A.Z pattern has a highly significant correlation with the orientation of the CTCF motif for each of the clusters that feature the CTCF/H2A.Z peak pattern: cluster 36884 (0.33, P<e-32), cluster 36426 (0.39, P<e-19 ), cluster 36420 (0.29, P<e-5 ) while there was no correlation in the remaining clusters ( Table 1 ).

Mitosis The “Mitotic metaphase/anaphase transition” (Reactome) was detected by the GSEA method ( P GSAE = 0.0040) and was marginally significant using ARTP ( P ARTP = 0.0187).

Expression of IFN-γ showed a trend in reduction in BaffR-ApoE DKO mice, but the result was not statistically significant.

Triggering of CD16 led to the phosphorylation of FYN on the N-terminal serines S21, S25, and S26, whereas the adjacent Y28 showed a trend toward dephosphorylation ( Figure S6 ).

In all the eight health domains (mobility, self-care, pain and discomfort, cognition, interpersonal relationships, vision, sleep and energy, and affect), the prevalence rates followed a positive trend.

We do indeed observe a correlation between mitochondrial synonymous diversity and allozyme diversity both across the whole dataset and within each group of organisms ( Table 1 , figure 1 ), with many of the correlations being significant or nearly significant.

Principal Findings Directionally consistent and biologically plausible overlapping and specific changes were detected: 14/25 of the human genes and 12/25 of the rat genes showed nominally significant differences in gene expression (global p values: 9×10 −14 , 7×10 −11 respectively).

Outcomes of the clustering of local versus regional datasets might differ with slight significance, depending on the threshold chosen.

PLPtg/PD-1-/- double mutants, compared to PLPtg mice, showed a clear trend of increased vacuole numbers (13.3±7.9 versus 7.95±3.6), while wt and PD-1-/- mice never displayed any vacuoles (data not shown).

Nevertheless, colonies of this species also showed a trend toward lower content of PS2 and Rubisco at high temperature similar to that observed for Turbinaria .

PLPtg BMCs transplanted with PD-1-/- bone marrow showed a highly significant increase of axonal damage ( Figure 2F, G, H ).

IL-2 or mbIL15-expanded NK cells showed a nonsignificant trend towards slightly longer mean telomere lengths during this first week, whereas mbIL21 caused a significant increase in the mean telomere lengths of expanded NK cells ( Figure 6A ) despite having the greatest amount of proliferation.

Examination of the 2N2K cells revealed a highly significant increase in the proportion of 2N2K cells undergoing abscission from 13% to 41% at 12 hours post-induction ((one way ANOVA and Dunnett's post-hoc test; F = 106.80, df = 8, p = 0.00); Fig. 4D, 4E ).

One study showed a positive trend [9] .

In the irradiated PLPtg mice statistical significance was reached, while the PLPtg/RAG-1-/- mice showed a trend into the same direction but did not reach the level of significance (p = 0.06).

Similarly, in analyses of cancer mortality, there was no evidence of any excess risk of death from cancer in older people and no evidence of an increasing trend in the rate ratio for cancer death with increasing age ( Figure 5 and Figure S6 ).

Morphological analysis Statistical analysis using a mixed model demonstrated that the differences due to genotypes and genotype×location interactions were highly significant at the 0.001 level of probability for all of the 14 traits ( Table 1 ).