Barely Significant

Excerpts

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These results, along with those in Figure 3 , showing that a mixture of UreB237–251 and UreB321–339 (B cell epitope) plus CT-adjuvant yielded an enhanced IFNγ response and a nearly significant reduction in bacterial load, encouraged us to generate a CTA1-DD fusion protein, which contained a single copy each of both the T and B epitopes.
In vitro the 5-HT transporter, a critical element in neuronal 5-HT uptake, appeared specially upregulated with the poly(I:C) treatment and showed an important trend to increase in the hippocampal culture when costimulated with IFN-α, which may support the idea that the deregulation of 5-HT biosynthesis and metabolism may be involved in the development of this depression type.