Excerpts

The IP delivery of HuMab 37 L-63 , gave an encouraging trend toward extended survival that was not statistically significant.

An increasing trend in BACE1 mRNA levels was observed in cells treated with H 2 O 2 , but this was not statistically significant when normalised to either actin or β2-macroglobulin mRNA ( Figure 2D ).

In the final model time of sampling was found to be highly significant (P MCMC <0.001).

We recall that a z-score of 1.5 roughly corresponds to a 95% percentile and hence, larger values indicate a highly significant difference.

Demographics and patient characteristics were similar across the patient groups (ε2 carrier, ε3/ε3 and ε4 carrier), though presence of RF was borderline significant ( Table 2 ).

The effects of environment Ambient temperature had a highly significant influence on both total incubation and female share ( Fig.

This difference is highly significant statistically ( Table 2 ).

Axyris and the mostly annual Atriplex , however, there is an evident trend to develop a thin yellow testa.

A larger cell typically has higher recovery, but this is a weak trend, with large variations in recovery between cells of similar size.

There was a significant trend of higher cumulative live birth rate in women with higher AMH or AFC.

One explanation might be the mild but highly significant 1.5-fold increase in liver iron measured in these heterozygote mice (85 ±13 μg/g wet tissue in WT mice n = 11, vs 132 ±22 μg/g wet tissue in Hepc+/− mice, n = 11, p = 2.8E-05).

Given the fact that vitamin D is generally deficient and metabolically disordered in patients with CKD [8] , [9] , supplementation of vitamin D may be significant throughout CKD evolution, especially at early and moderate stages.

Of the limited clinical studies that have explored extra-skeletal benefits of vitamin D, the VITAL trial (selective vitamin D receptor activation with paricalcitol for the reduction of albuminuria), a well-designed and relatively large-scale study, has shown promising but borderline significant results concerning albuminuria improvement [6] .

Although there was no significant association of S3, S5 or S29 with SCZ for the full US cohort or low antipsychotics dosage subgroup, for the high dosage subgroup significant associations of S5 ( Table 4 ; p = 0.034) as well as S5–S29 haplotype ( Table 3 ; p = 0.034) with SCZ were observed, as well as an evident trend that the p -values of association were lower in the high dosage subgroup than in the low dosage subgroup.

The main molecular pathways identified by the analysis of POST microarray data are more varied, encompassing categories with large numbers of molecules (pyrimidine metabolism, purine metabolism, protein ubiquitination), and more specific pathways with a highly significant p-value, but with much fewer misregulated genes.

Lowered pitch was heard as less attractive (F 1.12,16.80 = 3.793, p = 0.065), though the main effect of pitch height was only marginally significant.

However, there is an important trend suggesting an impairment in BTBR mice: BTBR mice made nearly double the total number of errors in learning the initial discrimination, when compared to C57 mice (BTBR: 68.2±13.8; C57∶39.3±5.6; p = 0.068).

In late childhood, lepromatous leprosy risk shows a slight trend towards male bias; although 95%CIs included 1 in all year-specific analyses ( Text S2 ), the random-effects mean IRR was estimated at 1.50 (95%CI 1.09–2.05) ( Table 2 ).

Our meta-analysis of published Brazilian infection-without-disease tuberculosis surveys, including tuberculin skin tests (TST) [69] – [72] and, in one case, TST plus an IFN-γ release assay [73] , revealed a marginally non-significant male bias in exposure to Mycobacterium tuberculosis (random-effects OR 1.16, 95%CI 1.00–1.36; N = 6725 subjects; Figure 4 ).

Supporting this second hypothesis, further experiments with growing populations in which evolution is initiated within a single niche, and where each niche has a limited capacity (but where selection is random within a niche) demonstrate a significant trend towards increasing genotypic evolvability over time.

Taking into account the small magnitude of the excess and its marginal significance, we conclude that adaptive evolution during nasal carriage of S. aureus must be rare.

We used survival analysis models to predict the development of criminality in adolescence and adulthood: high childhood hyperactivity was highly predictive when bivariate analyses were used; however, with multivariate analyses, high hyperactivity was only marginally significant (Hazard Ratio: 1.38; 95% CI: 0.94–2.02).

The negative relationship for the order Odonata (dragonflies and damselflies) was nearly significant.

As expected, pathways associated with specific immune functions were well represented and highly significant, including the B cell activation, T cell activation, Interferon-gamma signaling pathway, and Interleukin signaling pathway.

Additionally, the small spatula size recorded supports this hypothesis, as the evolution from small to large spatulae is presumed to be an overall trend, with the exception of strictly ambushing hunters specialized for a particular microhabitat (esp.