Excerpts

We selected pathways that were co-mutated in 2 or more samples, and had a co-occurrence P value that was nominally significant.

The three corresponding linear relationships ΔAT 2 = f(α) were highly significant ( Figure 4B ), providing the numerical values of ΔT R 2 and L R for each point of stimulation.

However, the observed inverse association was only marginally significant after correcting for multiple tests ( P 1000 = 0.049).

A marginally significant effect of the interaction between H. annuus accession and treatment is explained by lower glandular trichome counts on the leaf edge observed in jasmonate-treated ANN1238 (p = 0.09).

Additional Variants Associated with Serum Lipids Among other variants, an association for CELSR2-PSRC1-SORT1 (rs599839) showed a marginally significant decrease in LDL-C (online Table S1 ).

Although GWASs provide representative SNPs from the entire genome, many SNPs with a low or marginal significance are frequently excluded to effectively retrieve highly significant and representative tagSNPs.

Both findings, although highly significant, referred only to a minority of focus bees , at a proportion of less than 10% in Fig. 5B,C or up to a quarter in Fig. 6A,B of the full number of identified wave incidents.

In summary, a highly significant 9–10-fold reduction in antibody response to hFVIII protein was achieved with the cohFVIII construct including a complete lack of response to hFVIII protein in 5/8 mice.

This was somewhat reflected in adoptive transfer experiments, where CD4 + CD25 + cells from AAV8-F8-only treated mice showed a trend for greater suppression compared to cells from “AAV8-F8+αCD20” mice, although this did not reach significance.

Indeed, no significant difference was apparent in the biological response between patients receiving a polyester or an expanded polytetrafluoroethylene stent graft, except for serum concentrations of IL-8 [26] .

The effective diffusion of PTP1B D/A in the ER was three-fold lower than that of PTP1B WT: 0.070 + 0.003 μm 2 /s, with a highly significant immobile fraction of 0.28 + 0.02 (n = 13).

Single marker ANOVA revealed highly significant association with genotype at Chr 1 and Chr 18 markers (peaks at D1Mit306 and D18Mit123 , respectively, Table 1 ).

Bilotta and colleagues, in their study on community-dwelling outpatients, also found a negative trend of quality of life with frailty status [5] .

Measurements of post-mortem tumor volumes and weights (day 25) confirmed the highly significant reduction in tumor growth in anti-GD 2 -miR34a-NP treated mice ( Figure S6 ).

The distal tubular marker H-FABP showed a trend to reduction following NSAID treatment.

The time course of satellite cell population divergence between males and females suggests that androgens may be significant mediators of satellite cell number.

While the friction coefficient showed only slight variations between the subpopulations, and exhibited a clear trend.

These associations showed a trend, but appeared not statistically significant after stringent correction for multiple testing according to Holm-Bonferroni ( p <0.003).

When Social Interface was modelled the slope of the association with experiences of care was higher for older service users (borderline significant).

We demonstrate that there is a highly significant and independent association of increased plasma amounts of MIF in ACS.

The mortality in affected pens varies from almost insignificant up to 20%, while morbidity is close to 100% [2] , [3] .

Conversely, in the Breast Cancer International Research Group (BCIRG)-001 trial the combination of docetaxel (Taxotere®), doxorubicin (Adriamycin®) and cyclophosphamide (TAC) offered a significant improvement in 3-year DFS in patients with luminal B (defined as ER-positive, PgR-positive and either Ki67 high or HER-positive), but only a marginal trend in patients with TNBC or HER2-enriched tumors over treatment with fluorouracil, doxorubicin, cyclophosphamide (FAC).

Part of the hyperpallium showed a strong, nearly significant, increase.

There was an overall trend of declining annual incidence rates of Beijing strains ( Figure 1A ).

The antitumor and protective effects of jacaranone are highly significant at low therapeutic doses.