Excerpts

In this study, Ang-2 was elevated in CM-R compared to UM and CNS controls but became of borderline significance after correcting for multiple comparisons.

The HSP70 response was close to being significant, with clear differences between individuals from the Antarctic control and both the elevated and lowered pH ( Figure 1 ).

However, re-refinement of the tubulin structure produced some quite significant (∼2.8 Å) local deviations in Cα positions (with concomitant differences in sidechain positions) compared to the deposited structure, of which, intriguingly, the largest are localized near the colchicine binding site.

p<0.05 was considered to be marginally significant. 5–12 samples were analysed per surface marker, cytokine and tissue.

Of the eleven ELISAs applied to the ‘discovery’ cohort (n = 47, one sample was unavailable for validation), six (NrCAM, YKL-40, chromogranin A, carnosinase I, transthyretin, cystatin C) showed statistically significant or near-significant differences between CDR 0 and CDR 1 groups ( Figure 4 ); five others (PEDF, beta-2 microglobulin, clusterin/apoJ, ceruloplasmin, apoE) did not.

Haplotype AAA of GABBR1 was present more frequently in the sample cases than in the controls (with frequency distributions of 0.822 and 0.733, respectively) and had a highly significant p-value of 6.46×10 −5 .

While we found an increasing trend with increasing TNT concentrations ( Figure 3 B ), our system does not have the predictability reported by Looger et al [5] .

While the levels of hASM in the different regions of the brain were not significantly different from each other, rats administered 10 mg/kg hASM showed a trend towards higher levels in areas that were adjacent to the lateral ventricles (e.g., striatum, hippocampus and thalamus).

Bar charts for WHODAS-II and chronic disease groups show a clear trend towards worsening PGC morale rating with increasing disability from chronic illness ( Figure 2A, 2B ).

The presence of four sacrals (DS+S1+S2+CS) in Leonerasaurus , coupled with its smaller body size and its position as the sister group of the large bodied clade of Melanorosaurus +Sauropoda, is highly significant for understanding the origin of the sauropod-type sacrum.

We also displayed the consistency across several POPs associations that were significant or marginally significant (p trend or p quadratic <0.1) in Tables 1 , 2 , 3 , 4 and in Figure S1 and Figure S2 .

Interestingly, CD11c + cells showed a trend toward an increase ( Figure 7C ).

In fully adjusted model, a borderline significant inverse dose-response relationship was observed for MUFA intake (p for trend = 0.053).

The association of CAD, but not the one of T2DM, with T16189C remained highly significant after correction for age, sex and body mass index (BMI) and was independent of the two study centers.

Additionally, when ET-1 concentration is maximal, the inhibition of its effect is barely significant, in accordance with the action of reversible competitive antagonists.

A significantly attenuated neurotoxicity in nontransgenic mice (i.e., very little loss of dopaminergic neurons with the dose of MPTP causing ∼50% reduction in our study) observed in this study suggest that there may be significant strain background and/or other transgene specific effects [27] .

Importantly, some of these biases correlated in a highly significant manner with biological features, including transcript length, gene expression levels, conservation levels, and exon-intron architecture, misleadingly increasing the credibility of results due to them.

Many of the significantly associated SNPs in the discovery phase were either insignificant or of marginal significance in the replication phase.

However, some caution must be taken on this conclusion, as most of the isolates come from wheat, AI and PS might be significant just because most of the branches in the tree share the same state.

Glucokinase (GK) gene expression was also lowered in HP fed rats, but to a lesser extent than L-PK and also showed a trend to recover progressively during adaptation.

In our study, APOE KO animals fed a HFD showed a trend for higher levels of soluble Aβ40 and Aβ42 compared to all other APOE genotypes ( Figure 6 ).

In the 70-gene analysis the degree of concordance between matched FFPE and FF samples was high (R 2 = 0.94) and, most intriguing, the prognosis prediction made using 60 DASL gene index showed a trend in agreement with the prediction of the diagnostic test MammaPrint [33] .

pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY Introduction Though malaria remains a major public health problem worldwide, particularly for the poorest countries [1] , a decreasing trend of its burden, including in sub-Saharan Africa, has been recently reported [2] .

The permutation P value for testing the null hypothesis that there is no relation between 2,446 genes and TTP, which is the tail area of this null distribution beyond the log-rank value obtained for the real data, was estimated 0.06, suggesting a borderline significance of the association.

The links within the real networks are highly significant individually or in aggregate, possessing much higher semantic similarity than random links ( Table 3 ).