When the multivariate analysis was done, a highly significant association ( p < 0.001) was seen between podoplanin expression and grade of differentiation in normal mucosa versus OSCC.
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If corrected for age, the NfL increase in ataxic SCA3 subjects remained highly significant in both cohort #1 ( F (1,147) = 406.54, P < 0.001; based on a linear model with the factors group, age and their interaction, R 2 = 0.82; Fig 1 C) and cohort #2 ( F (1,70) = 169.49, P < 0.001, R 2 = 0.79; Fig 1 D).
Analysis of molecular variance (AMOVA) revealed a highly significant variation ( P < 0.001) among populations ( F ST ), and phylogenetic analysis revealed that populations from the two mountain systems formed their own distinct clade with >90% bootstrap support.
The main effect of Intervention was highly significant (F [1, 34] = 99.60, partial eta squared [η 2 p ] = 0. 746, p < 0.001), whereas those of Hand and Group were both non-significant (F [1, 34] = 1.82, η 2 p = 0.051, p = 0.187 and F [1, 34] = 1.76, η 2 p = 0.049, p = 0.193, respectively).
Paired t -tests indicated that, on average, a highly significant decrease could be observed, both for the first warning (mean round 5 = 6.31, SE = 0.37, mean round 6 = 4.78, SE = 0.39, paired t -test: t = 3.66, p < 0.001) and the second warning (mean round 16 = 6.96, SE = 0.34, mean round 17 = 5.14, SE = 0.42, paired t -test: t = 4.83, p < 0.001, see Fig. 1 a).
In patients, who had adjuvant therapy (n = 5) the increase in ADC values between pre- and post-EBRT did not reach statistical significance using two of the measurement methods (L-ROI mean , P = 0.084; S-ROI min, P = 0.105), while in patients with no adjuvant therapy (n = 47) the increase was highly significant with all ROI measurement methods ( P = 0.001) ( Table 3 ).
The difference was highly significant in every case for HRs ( p < 0.001) and in two of four cases for FARs.
Regionally, snow damage showed a similar trend in each of the 6 the regions (linear trend, p<0.001 for all regions), whereas wind showed a decreasing trend only in some regions (linear trend, p<0.001 only for regions 4, 5 and 6) as well as browsing (linear trend, p = 0.02 for region 6).
The onset of hypoxia triggered a highly significant ( P < 0.001) avoidance response, i.e. migration onto clumps.
funestus is highly significant ( χ 2 = 30.7, df = 1, and P < 0.001). 77% of An. arabiensis sampled from houses with LLINs fed on bovine host, to a lesser extent on mixed human/bovine (5.7%), and none (0%) was positive for human blood meal.
There were highly significant correlations between HOMA-IR and insulin in both diabetic patients (R = 0.961, P = 0.001) and control subjects (R = 0.975, P = 0.001) ( Table 1 ).
In the chronic phase, VA differences became quite significant ( p < 0.001) with an average VA of 0.75 Snellen in Group 2.
The pharmacokinetic parameters revealed enhancement in oral bioavailability when FLT was delivered as niosomal formulation, confirmed with highly significant AUC 0–∞ with 2 folds increase of FLT-loaded niosomes (741.583 ± 33.557) compared with free FLT suspension (364.536 ± 45.215) that was significant with ( p -value < 0.001).
The statistical significance of these findings was assessed through P values, with aphthous ulcers demonstrating a highly significant prevalence ( P < 0.001) compared to other diseases.
Worsening was highly significant when compared to basal values (time sequence ARDS vs. basal value, BV; all p < 0.001 for each parameter respectively, in both lavaged groups), but comparable between the lavaged groups.
The associations among the scores on MP1 and MP2 in 2007, 2009, 2010, 2011 and 2012 were all highly significant (gamma ≥ 0.67, p < 0.001), with a particularly high gamma statistic of 0.99 between the severity scores in 2011 and 2012.
This said, the analysis of yearly (2011–2014) SSI incidence rates in EU countries has shown a decreasing trend in the KPROs ( p < 0.001).
Nine SNPs located in the CD46 locus were genotyped previously [ 40 ], and none of them, except rs2796265, showed a nominally significant association with HIV-1 status ( p = 10 −3 ) ( Supplementary Table S1 ).
Only quintile 5 (most adherent diet quintile) of AHEI-2010 at baseline showed a significant association with diabetes [IRR 0.67; 95% CI 0.58, 0.78;] in model 1 and there was a significant trend ( p < 0.001) across quintiles.
There were highly significant differences between most irrigation trials at (p < 0.001) as indicated by the LSD values.
All pairwise comparisons yielded highly significant results ( p < 0.001 ), confirming that accelerometer fusion provides statistically significant performance improvements over ECG-only classification at every noise level tested.
Regarding both PR and p53 expression, the difference between the LMS group and the three non-sarcomatous groups was highly significant (p < 0.001).
A highly significant increase was also measured in the INL/OPL (48% increase, p<0.001) and the NFL/GCL layer (35% increase, p=0.002).
There was a highly significant statistical difference in IgE levels between patients suffering from AFS and CRSwNP (p <.001), with AFS cases showing higher IgE levels (mean (SD) IgE level in IU/ml: 820.2 (752.8) vs. 242.1 381.3)).
nagoyae populations for both the ITS region ( F st = 0.63608) and LSU rDNA ( F st = 0.63172) were highly significant ( P < 0.001).