A1 in both macaques and humans showed robust response profiles across the 16 stimulus categories ( Figure 1 E) that correlated well across hemispheres particularly in humans and with borderline significance in macaques (human A1, left versus right, median bootstrapped Spearman’s rho = 0.708, bootstrapped p = 0.0012, below the Bonferroni-corrected threshold of p = 0.05/8 = 0.0063; macaque A1, left versus right, rho = 0.608, p = 0.007, n.s.).
A subgroup analysis, stratified by the control group’s intervention, showed a highly significant difference between subgroups (p=0.0012).
Incubation of whole blood samples from healthy volunteers with LPS revealed a marked 4.3-fold increase in CD45 expression on endotoxin-stimulated granulocytes from 26,898 ± 2985 to 114,144 ± 5293 ( p < 0.0001), and a gradual, but highly significant, increase on lymphocytes from 119,202 ± 8970 to 158,107 ± 6564 ( p = 0.0012) and monocytes from 209,266 ± 15,953 to 284,693 ± 11,880 ( p = 0.0005).
While comparing the IS and IT TIL values with their corresponding breast cancer Immunohistochemical subtype, it was found that TNBC (p=0.0008) showed a highly significant association with the IS and IT TIL score followed by HER2BC (p=0.0012) exhibiting the same, whereas HRBC (p=0.3582) did not show a significant relation with the TIL score.
In the spleen, while there was a general tendency for the increase in parasite burden between day 15 and day 60, in the case of IMT-151 this increase (0.3 log on average) did not reach statistical significance, while ITMAP-263 and IMT-202 exhibited a 0.7 log increase in spleen parasite burden in the same time interval ( p = 0.0012 and p = 0.0008 between day 15 and day 60, respectively for each parasite strain) (Fig. 3b , d and f ).
This decline in origin copy number in stationary phase is highly significant ( t -test, p = 0.0012).
Furthermore, a significant trend also revealed poorer OS in the high-risk group compared to the low-risk group (log-rank P = 0.0012, Fig. 4G ), as well as in the GSE9891 validation cohort (log-rank P = 0.014, Fig. 4H ).
However, this difference turned out to be entirely due to the AD patients without depression, who had a highly significant lower PVN-PACAP level compared to the controls ( p = 0.0012).
A highly significant positive correlation ( r = 0.75, p = 0.0012) between marker density and the intrachromosomal LD blocks was observed ( Figure 3 ).
This is reflected in the large and highly significant regression coefficient (position = −1.32, p = 0.0012).
In the non-EA participants (137 cases, 120 controls), rs17538288 remained nominally significant (OR, 2.06; 95% CI, 1.34 to 3.22; P = 0.0012 ) and rs7546189 did not (OR, 1.29; 95% CI, 0.81 to 1.87; P = 0.33 ).
A slight downregulation of AT5G17700 in atml1 mutants (1.9-fold higher expression in Col_WT versus atml1 ) did not reach statistical significance ( p = 1.2 ⋅ 10 -3 , but padj = 1 after multiple testing correction).
After 8 and 16 weeks of fortnightly therapy, levels had risen to 105% and 89% for oestradiol and 110% and 86% for oestrone respectively. Cortisol levels fell, from a pretreatment level of 490nmoll1' to a mean of 334nmoll1' after 2 weeks, then rising to 370 nmol l-' after 8 weeks (Figure 3), the fall between weeks 0 and 2 being highly significant (P = 0.0012).
Tumours showing high levels of expression showed a highly significant excess of allelic imbalance (67 loci imbalanced vs 54 balanced) over those with low-level (42 imbalanced vs 81 balanced) expression ( P =0.0012).
Given that only 13.3% (3004/22500) of the probes analyzed were overexpressed in those experiments, this enrichment is highly significant (p = 0.0012; Chi square test with Yates correction, 1 degree of freedom).
16 at position 2 was nearly significant (P = 0.0012, marker LEI258).
A significant trend toward the peritumoral TILs pattern was observed, demonstrating higher PD-1 cell counts ( P = 0.0012).
Analysis of variance (ANOVA) demonstrated that the model was highly significant (F = 17.74, p = 0.0012), with a determination coefficient R 2 of 0.88 and adjusted R 2 of 0.83, confirming the reliability of the regression.
Despite this, the eliminations in this study ( Figure 4 a,b) were highly significant ( p = 0.0012): in a system with three plants the removal on average was 79 and 80%; in systems with six plants 80 and 82%; in systems with nine plants 61 and 64%, and in controls without vegetation 84 and 90% in PET and PRS substrate respectively.
However, after 24 h, there is an increase in the expression of phospho-p38 MAPK, which is highly significant at 48 h compared with its control group ( p = 0.0012; Figure 4D ).
Highly significant correlation was observed between Ψ w and the photosynthetic pigments (chlorophyll, r = 0.8532, p < 0.0012; carotenoids, r = 0.8821, p < 0.0007).
Based upon the frequency of these alleles in the SDP (11/18 alleles for the upstream marker and 0/18 alleles for the downstream marker; Table S3 ), this difference is highly significant ( p = 0.0012 for the upstream markers, p <0.0001 for the downstream marker, Fisher’s exact test).
Such a correlation was found to be highly significant in children from higher grades ( r = 0.82, p = 0.0012, Fig. 4 ), surviving Bonferroni correction for multiple comparisons between the two conditions and across the three groups ( p corr = 0.007).
We also found a nominally significant association between an exonic variant in ULK1 and triglycerides (p-value = 0.0012).
In addition to these previously established findings, we discovered nominally significant heterogeneity in the geographical distribution of haplogroup R1a ( p = 1.2 × 10 –3 ), enriched in Ceded Karelia (15%) and Satakunta (10%) (Fig. 3A ).