Excerpts

The AIC values are 273 ± 16 and 241 ± 23 for 1TCMR and 2TCMR, respectively, with a highly significant difference between those models ( p = 0.0011).

The permutation test yielded highly significant differences between the two groups with p = 0.0011 and p = 0.0014 for dimension 0 and dimension 1, respectively (10000 permutations).

This was highly significant ( p -value = 0.0011) when compared with the non-clustered (non-CRC) blood isolates, suggesting a possible association between certain specimen types and certain Bp clusters.

A significant trend over time was observed in both CD107a+,IFN-γ+ (p = 0.0011) and CD107a single positive (p = 0.0247) CD8+ T cells, with an increase at M2 and M3 and a reduction in the following months.

In addition, the protein expression of MMP2 and MMP9 in the MCM and MTM also showed an increasing trend after IκBα-siRNA intracameral injection by IF (MMP2 in the MCM, p = 0.0011; MMP9 in the MCM, p = 0.0013; MMP2 in the MTM, p = 0.0040; MMP9 in the MTM, p = 0.0106) ( Figures 5 E, 5F, 5H and 5I).

Highly significant positive correlations were found between DOC concentrations and the numbers of CTC + cells (r = 0.82, p = 0.0011) and EST + cells (r = 0.83, p = 0.0009).

The resulting difference between treatment groups for the mean change in visual acuity of individual eyes from baseline of RHODOS to the RHODOS–OFU study visit was highly significant, logMAR −0.228 (11 letters; P = 0.0011; Table 2 ), in favour of the idebenone group for patients carrying one of the three primary mitochondrial DNA mutations and logMAR −0.283 (14 letters, P = 0.0002) for patients carrying either the m.11778G>A or m.3460G>A mutation.

Subregional analyses revealed that this increase was highly significant in the caudal DG (71%; p = 0.0011), but non-significant in the rostral DG (p = 0.29) ( Fig. 2A ).

The difference between monotherapy and polypharmacy was highly significant ( p = 0.0011 [t = 3.276; df = 748]).

A highly significant correlation (rho = 0.775; P <0.0011, Spearman's rank correlation) between array and qPCR results was found, indicating that both methodological approaches yielded similar results and identified the genes that were either down- or up- regulated with accuracy ( Figure S2 ).

The increase in median PI between the first and second groups was highly significant ( p < 0.0001), and moderately significant ( p = 0.0011) between the second and third groups.

At 14a1, the Col allele was over-transmitted by 68% and this difference was highly significant ( p-value = 0.00111), while it was only barely significant ( p-value = 0.0734) for the 14a2 hotspot, probably due to the lower CO number.

In the case of Paso 144, the surface shows a curvature in T direction, as it is expected, since T 2 term was highly significant ( P < 0.00112).

However, the non-parametric Kruskal–Wallis test, applied for the comparison of all three groups, identified a highly significant overall difference (χ 2 = 13.56, df = 2, p = 0.001136).

The highly significant p -value ( p < 0.001157) confirms that patterns are present that depend on specific TFs; indeed, the association between frequency and AUC is definitely not driven by chance and has correlation value of 0.35, suggesting that while frequency has a significant influence, it is not the only factor playing a role in recognition.

This highly significant change in the distribution of binding loci ( P = 0.00116, Fisher’s exact test) could indicate a condition-dependent functional mode for NtcA in Synechocystis .

Of the detected DE proteins, 38 had expression changes that were highly significant (below the Benjamini-Hochberg procedure p < 0.00116) ( Supplementary Table S1 ).

The Kruskal–Wallis analysis showed highly significant differences in mean TPC values between control and samples treated with HA-MNP at different concentrations, both in stems ( p = 0.001175) and roots ( p = 0.001172).

In the non-EA participants (137 cases, 120 controls), rs17538288 remained nominally significant (OR, 2.06; 95% CI, 1.34 to 3.22; P = 0.0012 ) and rs7546189 did not (OR, 1.29; 95% CI, 0.81 to 1.87; P = 0.33 ).

A significant trend toward the peritumoral TILs pattern was observed, demonstrating higher PD-1 cell counts ( P = 0.0012).

A1 in both macaques and humans showed robust response profiles across the 16 stimulus categories ( Figure 1 E) that correlated well across hemispheres particularly in humans and with borderline significance in macaques (human A1, left versus right, median bootstrapped Spearman’s rho = 0.708, bootstrapped p = 0.0012, below the Bonferroni-corrected threshold of p = 0.05/8 = 0.0063; macaque A1, left versus right, rho = 0.608, p = 0.007, n.s.).

We also found a nominally significant association between an exonic variant in ULK1 and triglycerides (p-value = 0.0012).

Incubation of whole blood samples from healthy volunteers with LPS revealed a marked 4.3-fold increase in CD45 expression on endotoxin-stimulated granulocytes from 26,898 ± 2985 to 114,144 ± 5293 ( p < 0.0001), and a gradual, but highly significant, increase on lymphocytes from 119,202 ± 8970 to 158,107 ± 6564 ( p = 0.0012) and monocytes from 209,266 ± 15,953 to 284,693 ± 11,880 ( p = 0.0005).

In contrast, the RABV-exposed group showed a trend towards lower frequencies of RABV-specific IFN-γ-secreting T cells at different timepoints with a significant decrease at M6 ( p = 0.0012) compared to the RABV-unexposed group (Fig. 5B ).

As concerns the frequency of voluntary burying of the marbles, we found a highly significant interaction (F 2,21 = 9.431; p = 0.0012) among MIX-HET vs.