Excerpts

The extremely significant difference ( P = 2.6964E-08) between them suggests the specificity of these genes to distinguish the diabetic PDAC patients from the non-diabetic cases ( Figure 4 ).

Quantitative analysis evidenced a highly significant MEK5 6.2-fold increase (p=2.7×10 −8 ) and ERK5 5.5-fold increase (p=2.2×10 −9 ) in tumoral samples when compared to normal tissue ( figure 1j ).

5c ), and a paired t -test of the chromosome-level percentages was highly significant ( P = 2.722 × 10 −8 ).

The regression models reflect highly significant correlation values (Ras: R 2 = 0.78, P = 2.74E-08; RasGEF: R 2 = 0.35, P = 2.78E-03; RasGAP: R 2 = 0.38, P = 1.67E-03; RapGAP: R 2 = 0.38, P = 1.68E-03).

Comparing the full set of 1377 differentially expressed genes to those contained within the gene ontology term “central nervous system myelination” (accession number GO:0022010), we found highly significant enrichment of myelination-related genes (Fisher’s exact test, odds ratio = 3.66, p -value = 2.76×10 −8 ).

When the analysis was stratified by gender, one additional SNP (rs549485) located about 350 kb apart from the SAA1 subregion at 11p14 in the secretion regulating guanine nucleotide exchange factor ( SERGEF ) gene showed a borderline significant association with A-SAA levels in men (p = 2.76×10 −8 ) in the meta-analysis.

Strong and highly significant positive correlations were observed bilaterally between MMSE scores and GMV in the hippocampus (Right: R = 0.542, p = 2.83e-08; Left: R = 0.517, p = 1.59e-07), amygdala (Right: R = 0.48, p = 1.47e-06; Left: R = 0.403, p = 7.38e-05), and parahippocampal gyrus (Right: R = 0.45, p = 7.59e-06; Left: R = 0.407, p = 6.18e-05).

We observed a nominally significant finding (p = 2.9E-08, λ = 1.027 - corrected p gc = 2.2E-07, λ = 1.0015) on chromosome 6q21 in the gene coding for the non-receptor protein-tyrosine kinase, Fyn.

Protein-coding regions displayed 11.29-fold enrichment, 5’ UTR regions achieved 8.00-fold enrichment, while extended intronic regions showed 1.32-fold enrichment at extremely significant levels ( P = 2.92 × 10 –8 ), suggesting that these regions may participate in complex genetic mechanisms through regulation of gene expression or function.

MYO7A and PDZD7 were not only highly enriched, but the enrichment was highly significant statistically (p=3 × 10 –8 and p=2 × 10 –5 ).

Patient-derived OPCs exhibited a size distribution that was strongly shifted toward smaller cells, a finding that was highly significant across all patient and control lines (Kolmogorov–Smirnov D = 0.25, P = 3.0 × 10 −8 ; Fig. 3d ).

The omnibus test of hazard across the quartiles of Lp-PLA 2 activity was highly significant ( p = 3 × 10 −8 ).

While no individual epistatic association was genome-wide significant (p< 2.56e-10), several approached significance (p< 3e-8).

Such a difference would be highly significant for independent species (Kolmogorov–Smirnov test, p < 3 ∗ 10 -8 ).

The risk allele G of rs7535263 was also more frequent in cases (allele frequency, 64 of 104 [62%]) of cohort 2 compared with controls (allele frequency, 1451 of 2584 [56%]) but did not reach statistical significance, most likely representing an underpowered comparison (combined meta-analysis (OR, 0.58; 95% CI, 0.38-0.77; P = 3.0 × 10 −8 ) ( Figure 4 ).

The difference in the proportions of left and right flexions between the lumbar and cervical LHS groups was highly significant (Fisher’s Exact Test, two-tailed: p = 3 × 10 −8 ). 4.

In the sub-Saharan African sample, both the MAF and the DAF spectra showed a highly significant increase in the proportion of singletons with respect to the proportion expected under a constant population size model (χ 2 P = 3×10 −8 and χ 2 P = 9×10 −5 , respectively).

Analysis of variance indicated a highly significant genotype effect for both traits (p = 3.02 × 10 − 8 for LD; p = 2.04 × 10 − 4 for Survival%).

Also, for the women-only primary analysis, the rs77186623 in LOC105375745 locus associated with HIPadjBMI (β = −0.006, P = 1.74 × 10 −7 ) exhibited nominally significant interaction by background group ( I 2 = 55.3%, P diff = 0.042) and was GWS in the Caribbean group ( N = 3231, MAF = 0.041, β = −0.0078, P = 3.05 × 10 −8 ) but not significant in the mainland group ( N = 4216, MAF = 0.008, β = −0.0015, P = 0.567, Supplementary Material, Table S7 ).

For the RNA-seq Diet, we again found a highly significant overlap with 52% of up-regulated genes in Suv420h dKO overlapping with PPAR-γ targets (odds ratio, 1.6; 95% CI, 1.37 to 1.93; Fisher P = 3.1 × 10 −8 ).

Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10 −8 , odds ratios = 4.34) within a zinc finger gene, ZNF592 , from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis.

Statistical tests confirmed the highly significant differences in genetic diversity between subgroups Ia and Ib ( Z test p = 3.19 × 10 −8 ; T test p = 4.27 × 10 −8 ), and between phylogroups I and II ( Z test p = 1.64 × 10 −6 ; T test p = 1.04 × 10 −5 ).

This signal was driven by cases with and without extrarenal manifestations, since the burden difference was still highly significant when analyzing cases without extrarenal defects separately ( P = 3.21 × 10 −8 ; Figure 1A – B and Supplementary Figures 3 and 4 ).

Exposure of cells to ox-LDL resulted in a moderate increase in enhancer histone signals flanking this CRE (Figure 6 A) and highly significant increases in both the chromatin accessibility of this CRE ( P =3.3×10 −8 ) and MITF expression (average log2FC=0.39; P <2.2×10 −16 ).

However, when father’s age and mother’s age were entered jointly in a multiple regression, father’s age remained highly significant ( P = 3.3×10 −8 ), but not mother’s age ( P = 0.49).