Excerpts

A significant trend was observed across strata (Spearman rho = 0.257, p = 0.002), highlighting the clinical relevance of lactate thresholds in early risk assessment. 3.7 Model stability (EPV analysis) Events-per-variable (EPV) calculations are shown in Supplementary Table S8 .

The main effects of the groups were highly significant (F (4, 42.647) = 5.250, p = 0.002).

Importantly, for MTs, the predicted interaction of Shape and Gesture was highly significant ( F [1, 23] = 12.0; p = 0.002; η 2 = 0.342).

For men, we found a highly significant association with 95% CIs ranging from 0.04 to 0.48 ( p = 0.002), while for women, 95% CIs ranged from 0.40 to 2.71 ( p = 0.938) (Table 2 ).

The analysis of steroid levels in patients showed the following trends: Unconjugated steroids: A strong trend towards lower levels was found (n = 12 lower, n = 6 unchanged, n = 1 higher, p = 0.002).

C-reactive protein was nearly significant ( P = 0.002) in females ( S4 Fig and S4 Table ).

Fibrosis improvement was observed in 57% of norUDCA-treated vs 40% in placebo-treated ( P = 0.035), with highly significant adjusted mean ( P = 0.002). nonalcoholic fatty liver disease fibrosis score at week 18 and 24 ( P = 0.041 and P = 0.032).

The effect of DNMT3A genotype on birth weight and DNMT3B on length of gestation were the least significant before the exclusion and just below significance following the reduction in numbers; though the stronger DNMT3B effect on risk of prematurity remained highly significant (p = 0.002) after exclusion of the non-Caucasian pregnancies.

34 We observed a significant trend of increased PRKCH expression in metastatic samples compared with their matched primary tumors ( p = 0.002, t test, Fig. 1c ).

LT also showed a trend of reducing the risk of MS in multinomial logistic regression (Model 1, OR = 0.203, 95% CI: 0.072 to 0.569, P = 0.002; Model 2, OR = 0.149, 95% CI: 0.056 to 0.399, P < 0.001).

These variables were entered into the multivariate logistic regression model, which showed that individuals aged 70 years or older had a significantly higher likelihood of being within the molecular transmission network compared to those aged under 25 years (OR = 2.17, 95% CI:1.02-4.62), with a positive trend observed across increasing age groups (trend χ2=9.695, p=0.002).

At 3 months, PPD changes were −1.46 mm for the test quadrants and −1.25 mm coming very close to statistical significance (p = 0.002) with a further improvement to −1.74 mm in test quadrants and −1.55 mm in the control quadrants at 12 months with p values still not significant.

However, we detected a highly significant effect of time on MAYV titers in legs of mosquitoes ( F = 4.49; df = 9,20; p = 0.002) ( Table 2 ).

In this instance, a one-sample t -test was extremely significant ( T = 3.58, df = 11, p = 0.002).

The disease was statistically significantly associated with other chronic DM complications such as: i) peripheral neuropathy (p = 0.001), however, the association was only marginally statistically significant when adjusted for sex and duration of disease (logistic regression adjusted OR 1.70 95% CI 0.90–3.21); ii) coronary artery disease (p = 0.002), but again was only marginally statistically significant when adjusted for sex and duration of disease (adjusted OR 1.96 95% CI 0.91–4.22); and, iii) peripheral vascular disease (p = 0.009), however, this effect disappeared when adjusted for sex and duration of disease (Table 5 ).

The analysis resulted in a highly significant solution ( p = 0.002, inertia = 0.27, r 2 = 0.50), with significant eigenvalues for the three axes (lambda1 = 0.184, p = 0.001; lambda 2 = 0.0.046, p = 0.001; lambda 3 = 0.035, p = 0.001).

The model demonstrated moderate discrimination with a concordance index of 0.667, and the overall likelihood-ratio test was highly significant (χ 2 = 19.4, p = 0.002). 3.8.

Backward stepwise regression indicated three highly significant climatic Bioclim variables ( table 2 ), annual mean temperature ( p = 0.0020), annual precipitation ( p = 0.0047), and precipitation of wettest quarter ( p = 0.0063); and three marginally significant Bioclim variables, isothermality ( p = 0.0438), annual temperature range ( p = 0.0458), and mean annual diurnal range ( p = 0.0484). 4.

Using Fisher's combined probability test, highly significant associations between the deletion allele and the BSE cases were found for both the 23-bp (P = 2.01 × 10 -3 ) and the 12-bp indel (P = 8.66 × 10 -5 ) over all populations.

This number rose to 100 (60.6%) by the LV, and with an HbA1c average of 6.32 gm% and a lower ADMC (1.65), the difference was highly significant (chi-square = 9.531, df1, P = 0.0020203).

Due to our modest sample size, most of our results did not reach statistical significance after adjusting for multiple testing with Bonferroni correction (P < 2.08 × 10 −3 ) and warrant replication in independent Mexican pediatric populations ( Supplementary Table S1 ).

In the no ICI group, only sex was highly significant for better PFS in female patients ( P = .0021), and none of the variables were significant for OS (Table 3 ).

The correlation analysis revealed a highly significant positive correlation ( r = 0.7929, p = 0.0021) between the number of aphids and the incidence of S. sclerotiorum .

With the exception of females aged ≥50 years at years 2 and 4, where the proportional difference did not reach statistical significance, females aged <50 years were significantly less likely (p< 0.0021) to receive LTOWB compared with all other groups ( table 2 ).

In 2007 to 2009, a decreasing trend for mean BMI was significantly observed in those with a high income ( p =0.0021).