Excerpts

The results for the second variant under investigation (rs1470579) demonstrated that the CC genotype was more frequent in the patients' group (9.4%) than the control group (4.3%), with the statistical analysis displaying a highly significant difference ( p = 0.0029) between the frequencies of the C allele in the patients' group (25.3%) and control group (16.8%), as reported in Table 6 and Figure 5 .

We speculate that while our model shows a highly significant distinction between patients with a high or low risk of developing recurrence ( P = 0.0029, Fig. 3B ), the sensitivity and NPV of our and similar methods will not be sufficient to ethically withhold adjuvant therapy in the clinical application of a postoperative MRD‐test in stage II–III NSCLC.

This effect was highly significant across the population; locomotion significantly reduced the amplitude of phasic responses (p = 0.0029 with 4 Hz stimulation [ Figure 4 C] and p = 0.00033 with all stimulation protocols [ Figure 4 D]).

Unexpectedly, while there were no significant interactions between genotype and sex after correcting for multiple comparisons, there were highly significant effects of sex on these DTI metrics in each region where FA (Supplementary Fig. 4A ; LM, p = 0.0029, p = 5.25 × 10 −5 , p = 7.71 × 10 −4 ), MD (Supplementary Fig. 4B ; Tukey HSD, p adj . 2.83 × 10 −10 ), and RD parameters (Supplementary Fig. 4C ; LM, p = 4.04 × 10 −9 and Tukey HSD, p adj . < 1.0 × 10 −20 ) were all higher in the males.

In the first stage of this GWAS, we observed a moderately significant effect for rs401681 ( P = 2.9 × 10 −3 ), which was at genome-wide significance when combined with the Rafnar et al. data ( P = 5.0 × 10 −7 ; OR per C allele 1.11, 95% CI 1.07-1.16) ( Table 1 , Supplementary Figure 3 ).

In the RNA-Seq data, TET3 showed a trend for differential expression in the SGA placentas (DESeq: P = 0.0029; DESeq2: P = 0.00035).

Although we find some nominally significant changes for the targets of PRRX2 (p = 0.0029) and ARID3A (p = 0.0257), these genes actually have less overall amplification in the agiogenic subtype compared to the non-angiogenic subtype (t = −2.98 and t = −2.23 respectively).

This association is highly significant since the 10 isolated HSCR patients have only one variant but the 8 HSCR cases with additional anomalies have 7 variants (P = 0.0029).

The mRNA for Ch12, ORF39 (Spexin) demonstrated a highly significant 14.9-fold drop in expression in obese compared to non-obese fat tissues ( Figure 1B ), the largest change in gene expression observed in obese human fat (p=0.00292).

AD1) is highly significant ( P = 0.00298).

Moreover, a borderline association was found for respiratory rate as a risk factor for death/intubation (OR for unit increase = 1.07, 95%CI = 1.02–1.17, p = 0.01), while an increase of PaO 2 /FiO 2 had a trend towards significance as a protective factor for the composite outcome (OR for unit increase = 1, 95%CI = 0.98–0.99, p = 0.003).

As concern the speed, expressed as the number of inspected rows within the task time limit, a statistically significant difference was apparent between the two experimental sessions ( t 31 = 3.2; p = 0.003), as the subjects were faster in performing the test during T0 (mean ± SE = 19.12 ± 0.63) with respect to T1 (mean ± SE = 17.75 ± 0.7) (Fig. 1b ).

In the ANOVA for the VAS scores, the main effect of treatment was highly significant [ F (1,77) = 9.54, p = 0.003] and the main effect of time was significant [ F (2,77) = 4.47, p = 0.015].

For LinkedIn, the geographical effect was highly significant (η 2 = 0.041, p = 0.003).

Real-time RT-PCR analysis of mortalin transcript abundance in the anterior rudiment reveals two peaks of roughly 3-fold up-regulation, one on day 7 (p = 0.036) and another one on day 21 (p = 0.019) (Figure 9C ), while, in the posterior rudiment, the overall mortalin expression level shows a highly significant increase as early as on day 3 after evisceration (p = 0.003) and then returns to the approximately normal level on days 7 to 21 (Figure 9D ).

Sensitivity analyses were conducted with increased nursing minutes, resulting in slightly significant direct unit-costs for the palliative care unit ( p -value = 0.003), but not for the palliative care advisory team ( p -value < 0.001, see supplementary Table 2, Appendix 3 ).

An analysis of covariance with adjustment for age and sex suggested an overall trend across quintiles (adjusted mean ‘g’ = 0.02, 0.14, 0.13, −0.09 and −0.18 respectively; p = 0.003).

As shown in Table 2 , high WTAP expression was identified in 44.7% (84/188) of cases with tumors larger than 2 cm and in 28.9% (46/159) of tumors ≤ 2 cm; the between-group difference was highly significant ( P = 0.003).

A SH test showed highly significant support for Tree 1 ( p = 0.003).

Our results indicate that treatment with doxorubicin causes a highly significant decrease in both fibroblast ( P = 0.003) and osteoblast ( P = 0.013) colony forming units and concurrent treatment with 1D11 was able to significantly improved numbers of both CFU-Fs ( P = 0.013 ) and CFU-OBs ( P = 0.013 ) ( Figure 2A, B ).

Associations between the attractiveness of plants to aphids and plant VOCs There was no significant association between the attractiveness of plants to aphids and the amounts of individual VOCs, but there was a highly significant ( R 2 =0.66, F 6,23 =5.336, P =0.003) association between attractiveness and proportions of: ( Z )-2-hexenal ( T =3.42, P =0.003), ( Z )-2-heptenal ( T =–2.30, P =0.034), 6-methyl-5-hepten-2-one ( T =4.15, P =0.001), ( R , S )-β-pinene (T=–2.45, P =0.025), ( E )-caryophyllene (T=4.31, P <0.001), and ( E )-β-farnesene ( T =4.06, P <0.001).

Additionally, we further measured the rise in N2pc amplitude and the rise in CDA amplitude from one item to two items and found that there was also a highly significant correlation between the rise in the N2pc amplitude and the rise in CDA amplitude for both adults with ADHD (r = 0. 532, p = 0. 003, two-tailed) and controls (r = 0. 487, p = 0. 006, two-tailed).

Subjects with laboratory evidence of recent strep exposure (defined as either ASO or anti-DNase B antibody titers of equal to, or more than, the ULN value during pregnancy), showed a trend toward an association with asthma when compared with unexposed individuals (33.3% versus 11.1%, P = 0.003 considering Bonferroni correction). 4.

A higher three-year OS rate was found in the HS group, which was highly significant (RR 0.70, 95% CI 0.55-0.89, P = 0.003; Figure 2(b) ).

trachomatis infection at multiple time points ( Table S2 ), and linear modeling of log 2 [IFNα2] with SNP and 70 h post-infection burden as covariates revealed the SNP effect was much larger (regression coefficient = −0.623 versus 0.017 for burden) and was highly significant, with a p value of 1.87 × 10 −13 (versus p = 0.003 for burden) ( Table S3 ).