Excerpts

A significant trend was observed across quartiles in all models ( P for trend < .001 in Models 1 and 2 and P = .003 in Model 3), indicating a dose–response relationship.

Other domain z ‐scores (memory, language, attention) demonstrated significant differences (all p < 0.001), while visuospatial z ‐scores showed a modest difference which approached but did not reach significance (−0.07 ± 0.87 to 0.32 ± 0.78, p = 0.003).

This increasing effect was also nominally significant at order and family taxonomical levels ( Desulfovibrionaceae , P = 0.003), although the significance was lost after FDR correction for multiplicity.

T 2m was used to assess the extent of muscle oedema 5 and showed a trend to decrease over time at thigh and calf level over the iMOP ( table 1 , online supplemental figure 3 , Bonferroni-corrected p>0.003).

The difference between Tahiti and the rest of islands (excluding Tahiti) in the distribution of CFP events along the seven years considered was highly significant (χ 2 = 20.17, 6 d.f., p = 0.003).

After binarizing data (large values = 1, small values = 0), run tests showed near-significant ( Z = 1.772, p = 0.076) deviation from randomness for gene length and haplotype diversity, while nucleotide diversity displayed highly significant deviation ( Z = 2.938, p = 0.003), revealing a near-perfect “small-large-small-large” periodicity.

TBC1D1 gene, the top associated segment in autozygosity mapping, was nominally significant associated with time-to-spontaneous onset of delivery at the nominal level ( P -value = 0.003) in the gene burden analysis.

This difference was highly significant ( p = 0.003).

On comparing between the markers CK-10 and CK-19, OOCs showed significant difference with P = 0.011 and EDCs showed highly significant difference with P = 0.003.

In age-stratified analyses higher cheese intake was associated with lower cortical BMD at the radius and tibia in men and women over the age of 60 years [β (SE) per 1 serv/week: −7.40 (2.59), p = 0.01 and per 1 serv/week: per 1 serv/week: −7.82 (2.85), p = 0.01, respectively; Table S3 ), but these associations did not reach statistical significance ( p < 0.003).

A permutation analysis comparing patient-to-healthcare environment core versus accessory genome pairs compared with patient-to-patient pairs was highly significant ( P = 0.003), providing strong evidence that the higher similarity of healthcare environment-to-patient isolates compared with patient-to-patient isolates was not because of chance.

Breaking down the total antibiotic consumption to each of the study antibiotics and antibiotic groups, a marginal trend ( P -values for slope), suggesting correlation with CDI incidence, was seen for carbapenems (IRR 1.25, 95% CI (1.11, 1.42), P =0.003), ceftriaxone (IRR 1.14 (1.02, 1.28), P =0.04), cefepime (IRR 1.10 (1.05, 1.15, P <0.001), macrolides (IRR 1.24 (1.14, 1.35), P <0.001) and piperacillin/tazobactam (IRR 1.09 (1.02, 1.17), P =0.03) ( Figure S3 ).

There was also a nominally significant association at our novel locus, chr5:21360122:T:C ( CDH12 ; p = 0.003; Table S4 ).

Among responders, only 9.09% exhibited sarcopenia, whereas 45.45% of non-responders had sarcopenia, indicating a highly significant association ( p = 0.003).

These rises were shown to be highly significant ( p = 0.003, p = 0.001) for CVD-related mortality and nonfatal cardiovascular events in hypertensives with ≥ 3 CVD-RFs compared with hypertensives with < 3 CVD-RFs.

In addition, there was a significant interaction between Duration and Intensity, F (1, 42) = 8.7, p = .005, ηp2 = .17, due to a significant difference between the high and low magnitudes in the high intensity light bulb conditions in comparison to a marginally significant difference in the low intensity light bulb conditions (10.8, p = 0.003, vs. 8.9 seconds, p = 0.06, respectively).

While using the Cochran–Mantel–Haenszel test, which analyzes the correlation between the variables, the correlation appears highly significant (p = 0.003).

In the subgroup with COPD, the younger group took longer to return to their baseline COPD condition than the older age group ( P =0.004), as did hospitalized participants compared to nonhospitalized participants ( P =0.025), although these differences did not reach statistical significance when adjusted for multiplicity ( P <0.003).

Among them, fibrinogen alpha/beta/gamma chains (FG) exhibited notable differences, with their branched-chain protein FGB showing highly significant upregulation ( p = 0.003, Log 2 FC = 2.167) and tending to increase gradually during early pregnancy, suggesting that FGB could be one of the important indicators of early pregnancy in Chinese native yellow cattle.

The presence of significant arrhythmias in the first phase was associated with 5 times higher mortality, and even with this small study we were able to show a highly significant difference in outcomes. 19 This association was even stronger (HR = 6.04, p = 0.003) to the cumulative incidence of SCD and VT/VF events ( n = 12).

The repeated-measures ANOVA showed no significant day × group interaction ( F (14,38) = 0.73, ns), but a highly significant overall group effect ( F (2,24) = 7.62, P = 0.003) confirming that learning was impaired in the RT-HFS group.

Genotype GG was associated with significant increased risk of not responding to treatment by 4.25 times as compared with TT genotype ( p = 0.019) and the G allele was associated with highly significant risk of not responding to treatment by 2.56 times compared with the T allele ( p = 0.003).

Before intervention, the positive density of MDRO in the orthopedic ward showed an increasing trend (β 1 = 0.02, P = 0.003).

The severity of depression was found to be highly significant when cross tabulated with respondent educational status (p value = 0.003), inability to attend social gatherings (p value = 0.001), and drug intake to relieve tension (p value = 0.000).

Except for TVW PCR (p-values>0.5), study sites, and probably the husbandry method, together had a highly significant impact on the diagnostic tests results (all p-values<0.003) ( S3 Table ).