Excerpts

The initial consideration of the duration of T2DM, despite its nearly significant univariate effect (p = 0.0034), highlights the necessity for multicollinearity checks, a step often missed in earlier meta-analyses. 21 , 22 Strengths and Limitations Strengths of this study include the comprehensive analysis of 11 CVOTs with 83,536 participants, a PRISMA-guided approach, and the use of random-effects models with meta-regression to explore moderators.

Comparing mice infected with the first isolate (124A) with mice infected with the third (140A), or with the fourth (144), the overall differences in survival were highly significant ( P = 0.0034 and P = 0.0002).

Female teachers tended to give slightly higher grades than usual—an association which is significant in the random forest model (and the alternative linear regression model using weights, as is described S2 Text ), though not quite significant in the linear regression model (p = 0.0035), with a significance level of 0.0005.

The low ACE2/MIRb-ACE2 ratio in the upper aerodigestive tract was highly significant when compared with other locations (p=0.0035, when compared with the lung; p=0.0023 when compared with the large intestine, Student’s t -test).

In addition, when the mean peer marks of group U and M were compared with each other, the observed difference between the marks was highly significant ( p = 0.0035; Student’s t-test).

In contrast, there was a decreasing trend in pediatric BSIs (29.46% vs 25.85%, P = .0035, Fig. 2 d), which may be mainly ascribed to the sharp drop in the proportions of A. baumannii and S. aureus during the same periods.

Tregs Are Reduced in the Peripheral Blood of Stroke Patients Flow cytometric analysis confirmed the well-described loss of lymphocytes in the peripheral blood of stroke patients, which was highly significant on all days ( p = 0.0035).

Comparing mutations of A or T versus mutations of G or C, there is a highly significant difference among the XP-V and control clones (P = 0.0035, using a Monte Carlo analysis; reference 30 ).

We observed a highly significant ( P =0.0035) relationship between lung volume-to-body weight ratios and dynamic lung compliance, indicating that low lung compliance is closely related to LH.

2B , none of the PCM genes reached the genome-wide significance level, though nine genes had nominally significant P -values: DNM1 (MAGMA P = .0035), RERE ( P = .015), FOXP1 ( P = .018), NCL ( P = .019), CUL3 ( P = .024), NASP ( P = .027), KCNMA1 ( P = .03), SETD2 ( P = .044), and MBD5 ( P = .048).

A three-way ANOVA revealed a highly significant main effect of Bedding Condition (F 1,4 = 38.03, p = 0.0035) ( Figure 6 , Supplementary Table S12 ).

Patients with high TMB (>12 reported mutations), however, showed a trend towards improved survival when treated with ICB (HR = 0.586, 95% CI [0.275–1.246]) ( Figure 3C and 3D ) ( p = 0.0035 Log-rank (Mantel-Cox) test, p = 0.211 Log rank test for trend).

Results In the China subgroup ( n = 432; 22.7% of the KRONOS population), BGF MDI demonstrated nominally significant improvements in the primary endpoint versus BFF MDI (least squares mean (LSM) difference 68 mL; P = 0.0035) and BUD/FORM DPI (LSM difference 78 mL; P = 0.0010) but not GFF MDI (LSM difference − 4 mL; P = 0.8316).

On the other hand, LoF carriers were more likely to have a family history of breast cancer than non-carriers (OR 3.94, 95% CI: 1.07–18.10, P =0.023) and there was also a significant trend with the increase in the total number of breast cancer cases within a family ( P =0.0035).

This difference is highly significant (p<0.0035) in Fisher’s exact test.

Meanwhile, we also observed a highly significant negative correlation between the expression level of miR-429 and CRKL (R 2 = 0.5905, P = 0.0035, Fig. 2C ).

The significant enrichment of the early clonal driver GATA3 in the Nigerian group and a positive trend in its recurrence with African ancestry (proportion trend test, P = 0.0035) along with a significantly lower age at diagnosis in patients with tumors carrying GATA3 mutations is likely to be an underlying genomic event associated with young onset breast cancer.

Relationship Between the Sub-Dimensions of the SCOOHPI Scale and Demographic and Clinical Variables According to the study of the relationship between the three dimensions of the SCOOHPI scale and the sociodemographic and clinical variables, we find that only the third dimension (Activity and Organization) showed a nominally significant association with the DMFT index before correction for multiple comparisons ( p = 0.0035).

At 24 h, 36 h and 48 h the percentage of inhibition remained highly significant, but with a slight decrease as post infection time increased (78.9%, p = 0.0035, at 24 h; 75.9%, p = 0.0042, at 36 h and 73.9%, p = 0.0141 inhibition, at 48h).

This difference in hypocotyl posture was highly significant ( p = 0.0035; n = 4; Student’s t -test) and persisted from the moment of seed germination.

The HRs were nominally significant in LOADFS ( p = 3.54E−03) and CHS ( p = 2.19E−02).

Statistically, the enrichment of genes involved in cerebral cortex GABAergic interneuron differentiation only achieved a trend toward significance ( p = 3.6E-3; padj = 5.8E-2), which could be due to the relatively small sample size.

Two-tailed student T-test results indicated highly significant correction of LAMAN enzyme deficiency by rAAV6-LAMAN in comparison to untreated mutants at both time points ( P = 0.0036 and 0.000006, respectively).

The gene-wise set test for the association of FMR1 with QIDS-SR was nominally significant with P=.0036, a probability which does not meet Bonferroni criteria for 36 genes tested (see Additional file 1 , sheet 2).

Using a Fisher’s exact test, it can be calculated that the distribution of proteins with altered versus non-altered protein amounts in the histone group (3 versus 4) was highly significant different from what could be expected among non-histone proteins (41 regulated and 830 non-altered non-histone proteins, p = 0.0036).