Excerpts

There is a highly significant interaction between genotype (treatment) and sex (p = 0.0032).

In line with this, a correlation analysis between NO and AsPgb expression revealed a negative trend across the full time course ( r = −0.32); however, this became stronger at intermediate stress stages ( r = −0.40) and became highly significant at 40%–45% sRWC ( r = −0.98, p = 0.0032).

LTA was of borderline significance (p = 0.051) in the multivariable model once BOT D50% was included, although it was highly significant (P = 0.0032) without BOT D50% in the model.

Moreover, the increase in the network efficiency in the dual-mode stimulation group was noticeably significant compared to those of the rTMS-only group (group∗time interactions: weighted network efficiency, F 1,22 = 10.91, p = 0.0032; binary network efficiency, F 1,22 = 9.80, p = 0.0049, Supplementary Table 1 ). 5.

However, we found a moderately significant negative three-way interaction term (−0.0318) between ethnicity, education, and predicted cognition ( p -value = 3.22 × 10 −3 ).

Although differences were small and statistically insignificant during the early phase (Day 3–6, p > 0.05), the effect became significant on Day 10 ( p = 2.93 × 10 −2 ) and highly significant on Days 13 ( p = 3.25 × 10 −3 ) and 14 ( p = 1.69 × 10 −5 ).

The overall Φ ST value was highly significant (Φ ST = 0.644, P <0.0033) indicating strong genetic differentiation across all populations of T. newberryi .

AA amyloidosis showed significantly better survival (90.9%, one death in 11 patients) than AL amyloidosis (14.3%, six deaths in seven patients), yielding a highly significant difference (p = 0.0033).

The simulation confirmed that an intersection size greater than or equal to 41 is highly significant ( p = 0.0033).

37 The burden of de novo missense variants is also higher in constrained genes compared to non-constrained genes (fold = 1.57 versus 1.22), although it is marginally significant in both constrained and non-constrained gene sets (p = 3.3 × 10 −3 and 0.045, respectively).

Beta analysis based on weighted Unifrac distance showed no significant difference between the groups SMG and SMH (P = 0.51), while beta diversity test based on the unweighted Unifrac distance showed extremely significant differences (P = 0.0033) (Fig. 3 ).

Similarly, SSIM-based stability analysis demonstrated highly significant gains (p = 0.0033), confirming improved visual robustness and reproducibility of explanations.

We see by the GR 50 metric that PTEN mutant and wild-type breast cancer cells exhibit a highly significant difference ( p = 0.0033) in sensitivity to lapatinib treatment, which is not found by IC 50 value ( p = 0.12; Step 9).

The level of Th2 type cytokines was globally higher in patients compared to controls, particularly for IL-5 and IL-13 for which the difference was highly significant ( p = 0.0033 and p = 0.0002, respectively).

Specifically, the abundance of this receptor increased significantly, by 4.88‐fold, in the gastrodermis only of anemones exposed to 31°C versus 25°C (Tukey HSD post hoc test, p = 5.6 × 10 −5 ), though at the initial 34°C sampling point it was significantly more abundant (5.16‐fold) in the epidermis but not the gastrodermis, even though it was trending towards significance in the latter (Tukey HSD post hoc test, p = 3.3 × 10 −3 and p = 0.07, respectively).

A highly significant relationship between EGFR status and PFS was observed (P =0.0033) (Figure 2b).

Results: The results show that heterozygous (AG) of rs4977574 of the CDKN2B gene showed highly significant association with 2-folds increased risk of cardiovascular disease (CVD) (OR = 2.03; 95% Cl = 1.26–3.25; p < 0.0033) while heterozygous (AG) of rs2383206 of the gene CDKN2B exhibited significant association but with decreased risk of CVD (OR = 0.47; 95% Cl = 0.29–0.75; p < 0.0017).

This result confirms the efficiency of the therapeutic approach associating pharmacotherapy with psychotherapy, correlated with the highly significant statistical difference recorded among the values of HAM-D scores in the two analyzed groups ( χ 2 test, p =0.003336489, p <0.01).

Unexpectedly, all tocopherols showed a highly significant increase in the Aß level (a-tocopherol: 132.25 ± 4.45 %, p=0.0034, y-tocopherol: 134.22 ± 4.66 %, p=0.0026, ò-tocopherol: 136.86 ± 3.74 %, p=0.0011, mean: 134.44 ± 2.35 %, p=0.0038) ( figure 1 C).

Nominally significant methylation differences were observed (i) between carriers vs. non-carriers at cg11481443 (standardized regression coefficient = −0.306, p = 3.4 × 10 –3 ; Additional file 6 : beta-value and M value plots) and cg02936398 (standardized regression coefficient = 0.177, p = 4.9 × 10 –2 ; Additional file 6 : beta-value and M value plots); (ii) hATTR patients and asymptomatic carriers at cg14311811 (standardized regression coefficient = −0.273, p = 3.8 × 10 –2 ; Additional file 6 : beta-value and M value plots).

Overall, the mutations did not cause increased levels of phosphorylated NF‐kB, instead, most mutations showed a trend or significant reduction in phosphorylated NF‐kB (one‐way ANOVA F [5,49] = 4.11, p = 0.0034; MAP3K7 WT vs.

GNAS , which showed a nominally significant loss in population-level AI with age (LRT P =3.4×10 −3 ), also showed a significant decrease in individual-level AI with age.

Abdominal subcutaneous adipocyte area was nominally significant among different NAFL groups ( p =0.0034), with post-hoc analyses indicating a significant increase between NAFL 0 and NAFL 2 ( p =0.005) and trending increases between NAFL 0 and NAFL 1 ( p =0.052) and NAFL 1 and NAFL 2 ( p =0.054) ( Figure 2A ).

Suppressed expression of BAP1 occurred in 22 GBC cases (46.8%) and showed a strong trend toward a worse median survival time of 13.3 months (95% CI, 17.6–62.6) (p = 0.0034).

PKA activity assay from LV lysates showed a highly significant reduction (62%, p = 0.0034) in the IHD LVs compared with that of controls, while PKG activity remained stable ( Figure 3F ).