Excerpts

Indeed, expression levels of miR-22 and mimecan showed a highly significant inverse correlation (r = -0.76, p < 0.0052) suggesting that mimecan may be a target for miR-22 in the heart (Fig. 3c ).

We then quantified the relative abundance of the cells in each cell state throughout the aging process and found that the number of State 1 cells kept decreasing with age and that of the State 4 cells showing an increasing trend (State 1: p = 0.0052; State 2: p = 0.73; State 3: p = 0.72; State 4: p = 0.05).

In the reviewed version we removed results for LTAa 322 (marginally non-significant, p=0.0052) which prompted us to reformat the table.

There was a highly significant association between BKV and CMV for all three thresholds: BKV + -CMV + (p = 0.0052; OR = 1.97, 95%CI = 1.24–3.11), eBKV and eCMV (p = 0.0216; OR = 2.33, 95%CI = 1.18–4.60) and hBKV and hCMV (Fisher's exact test: p = 0.0016; OR = 5.75, 95%CI = 1.80–17.0).

Non-parametric spearman correlation of protein concentration ratios with the according gene expression ratios was highly significant (rs = 0.83; p = 0.0052).

There was some protein loss in the SDS-treated samples, reaching significance (p<0.001) in the 1% concentration group and approaching significance (p = 0.0052) in the 2% group.

Eleven out of these 45 pairs (24%) had the sham-immunized mouse succumb to infection by day 4, while none of the vaccinated mice showed mortality, a highly significant skewing ( p = 0.005278).

We found that five of the six recurrent chromatin regulatory genes described above (Table 1 ; not EP400 ) contributed to findings for the Constrained Genes set with borderline significance ( n = 968; Fig. 2 , panel 1, P = 5.28 × 10 −3 ).

Additionally, a 2 way ANOVA was performed that showed that the interaction between the combined effects of the agonist over time and inhibitor were highly significant (p = 0.0053).

In slope tests, men and women showed a trend-level difference in amygdala (L+R) rsFC with the right cerebellum ( t = 2.84, p = 0.0053), with correction for multiple tests ( p = 0.05/12 = 0.0042).

A borderline significance ( p = 0.0053) of age was found on the SMQ school subscale, with no age effect on the other two subscales measuring speech behaviour at home and in public ( p > 0.62).

The results suggest a highly significant interaction of parasitoids killed with time ( F = 11.64; df = 9, 119; p = 0.0053).

The difference between the tumour volume in animals treated with KM2760 plus G-CSF and those with KM2760 alone was highly significant ( P = 0·0053) ( Fig 1B and C ).

Iptacopan improved the eGFR slope by +10.7 mL/min/1.73 m 2 /year compared with pretreatment decline ( P = 0.0057) and also led to a nominally significant reduction in glomerular C3 deposition (mean difference: –1.875; P = 0.0053). 66 In a study evaluating early access use of iptacopan (200 mg twice daily) in 16 patients with recurrent C3G after kidney transplantation, iptacopan was associated with potential stabilization of kidney function.

This model (overall R^2 = 0.44) was clearly significant for ATIII ( p = 0.0053), LMWH dose pre-sample ( p = 0.0049), drug given (tinzaparin or enoxaparin) ( p = 0.03), and nucleosome levels ( p = 0.0453) ( Table 3 ).

sIL-2R index values were likewise higher in patients with neurosarcoidosis than in patients with MS, but this did not reach statistical significance after correction for multiple testing ( p = 0.0053).

Raised levels of vWF were determined in CE patients by Licata and collaborators but only showed a trend (10 (5-12) ng/ml; p=0.0053) compared to other stroke subtypes [ 33 ].

We found a significant trend of increasing SNIP values with milder types (JT = 743, P = 0.0053).

Although MIF showed a trend toward significance in the P1–P2 comparison (raw p = 0.0053), the adjusted value (adj. p = 0.0584) did not reach significance.

43 In MARTHA, plasma levels of hsa-miR-143-3p were negatively significantly correlated with BMI ( ρ = −0.24, P = 3.6 × 10 −4 ) and borderline significant with PAI-1 activity levels ( ρ = −0.21, P = 5.3 × 10 −3 ) ( Supplementary material online , Table S2 ).

Including patients receiving rhPTH therapy, a lower serum phosphate concentration (odds ratio 1.364 [95% confidence interval (CI) 1.049-1.776], p<0.05) and a longer disease duration of HPT (odds ratio 1.063 [95% CI 1.021-1.106], p<0.01) were significant predictors for renal calcifications, whereas 24-hour urinary calcium excretion was elevated in patients with renal calcifications but failed to reach statistical significance (odds ratio 1.137 95% CI 0.999-1.294, p=0.0053]) ( Table S3 ).

However, significant neurodegeneration was observed in water-treated IEI rats, and was highly significant in water-treated IEI/UMS rats compared to water-treated control rats (scores: p = 0.0053 and p < 0.001, respectively).

Individual ANOVA tests were performed on the VTA X and VTA MST populations which indicated highly significant changes in cell counts across age groups (VTA X population ANOVA, p = 0.00537; VTA MST population ANOVA, p = 0.012).

In contrast, the reduction of NPTX1, NPTX2, and NPTXR showed a highly significant correlation with the clinical response to tofersen (NPTX1: Pearson's correlation = −0.54, p value = 0.00538045, adjusted R 2 = 0.26, 95% CI −0.77, −0.18; NPTX2: Pearson's correlation = −0.64, p value = 0.00059559, adjusted R 2 = 0.38, 95% CI −0.83, −0.33; NPTXR: Pearson's correlation = −0.53, p value = 0.00602491, adjusted R 2 = 0.25, 95% CI −0.77, −0.18; Fig. 6D–F ).

The difference between mice depleted of CD8+ T cells and those depleted of CD4+ T cells was statistically highly significant ( P = 0.0054).