Barely Significant

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highly significantp= 0.00510.1× alphaqualifiedgold
These meta-analyses substantially confirmed a reduction of bleeding, without a significant reduction of mortality rate in patients treated with bivalirudin; however a re-evaluation of current data adding MATRIX study patients demonstrate for the first time highly significant benefits of radial access in acute coronary syndrome patients for major adverse cardiovascular events (p= 0.0051) and all-cause mortality (p= 0.0011) in patients treated with bivalirudin 19 .
nominally significantP = 0.005130.1× alphagold
Similarly, scores constructed from Latino GWAS results ( P T ≤ 0.5) were of greatest predictive value among Latinos (liability R 2 = 2%; P = 3.11 × 10 −19 ) and Europeans (liability R 2 = 0.8%; P = 1.60 × 10 −9 ); with scores based on P T ≤ 0.05 and pairwise r 2 < 0.1 showing nominally significant association with case-control status among African ancestry individuals (liability R 2 = 0.2%; P = 0.00513).
marginally significantp = 5.15E-030.1× alphagold
While not statistically significantly associated with aTRH in our other analyses, the variant had a consistent direction of effect in all our analyses, with marginally significant p -values for the multi-ethnic aTRH versus treated controls (OR [95% CI] = 0.88 [0.80–0.96], p = 5.15E-03), AA aTRH versus normotensive controls (OR [95% CI] = 0.83 [0.72–0.95], p = 8.47E-03), and EA aTRH versus normotensive controls (OR [95% CI] = 0.81 [0.69–0.94], p = 5.81E-03).
nominally significantP = 5.18E−030.1× alphagold
The proportion of heritability of persistent ADHD attributable to common single-nucleotide polymorphisms on the liability scale (SNP- h 2 ) was 0.19 (SE = 0.024), with a nominally significant enrichment in the heritability of variants located in conserved genomic regions ( P = 5.18E−03) and in the cell-specific histone mark H3K4me1 ( P = 3.17E−02) (Fig.
highly significantP = 0.005190.1× alphaqualifiedgold
In a GLM with a negative binomial transformation of seed number, the signal for MPK12 G53R on fitness was reduced but still highly significant (GLM, MPK12 53R allele fixed-effect estimate = 0.7, P = 0.00519) ( supplementary table S12, Supplementary Material online), indicating the MPK12 53R variant increases fitness independently from FRI 232X under CVI (Espongeiro) conditions.