Excerpts

The T levels of female fetuses were not associated with their father’s proportion in the litter (N = 47, F 1,44.68 = 0.003, P = 0.95), while the association for male fetuses was highly significant (N = 44, F 1,29.74 = 9.02, P = 0.0054) (Fig. 1 a).

The difference in the proportion of identified proteins in the GlyGly search was nearly significant (p = 0.0054).

1SMR analysis identified four nominally significant associations, including genetically predicted Cer(d39:1) with higher levels of ALT (β = 0.39; 95% CI = 0.11, 0.66; P = 0.0054), and AST (β = 0.32; 95% CI = 0.03, 0.60; P = 0.028), SM(d33:1) with higher HbA1c (β = 0.39; 95% CI = 0.12, 0.65; P = 0.0042), and PC(40:8) with lower bilirubin (β = −0.28; 95% CI = −0.55, −0.01; P = 0.044) ( Fig. 4 a, Supplementary Table S11 ).

However, in the dictated words, the difference in rates of orthographic errors between English and French children approached significance ( W = 885.5, p = 0.0054, r = 0.28), with more orthographic errors in the English word samples.

The difference between mice depleted of CD8+ T cells and those depleted of CD4+ T cells was statistically highly significant ( P = 0.0054).

Interestingly, however, the LRIG1 mRNA levels showed a decreasing trend ( P = 0.00547, Jonckheere-Terpstra test) with increasing tumor grade, i.e., from GS (Gleason Score) 6 to GS9 tumors (Supplementary Fig. 13a ).

In fact, slightly significant negative correlations between FABP1 (r = −0.27, p-value = 5.49 × 10 −03 ), FADS1 (r = −0.36, p-value = 1.93 × 10 −04 ) and FADS2 (r = −0.34, p-value = 4.46 × 10 −04 ) mRNA levels and BF C18:3(n-3) were observed ( Fig. 4 ).

We note as a caveat to this conclusion that, when we analyzed the subset of networks presented in Fig 3B that were generated with combinations of zero and three features, there was a marginally significant correlation between the number of external genomic features integrated and the proportion of interactions that were subsequently discovered (ρ = 0.17, P = 0.0055).

This stunning difference in the numbers of sites of the three site classes were highly significant between intron 2 and the remaining part of the gene (χ 2 : p=0.0055, power=1.0000), and the differences between the subregions were also statistically significant (intron 2 vs. non-cds without intron 2, χ 2 : p=0.0106, power=1.0000, intron 2 vs. cds, χ 2 : p=0.0091, power=1.0000, cds and non-cds without intron 2, χ 2 : p=0.0423, power=0.9989).

In contrast, there was no significantly higher prevalence of these CHI3L1-reactive Ig classes in CeD patients and only a barely significantly elevated prevalence of positive sIgA to CHI1L3 in UC patients [17/95 vs 4/86; p = 0.0055].

A progressive and highly significant increase in galectin-1 expression was observed with progression of MPN to fibrosis (monotonic trend from controls to PV/ET to myelofibrosis, P < 0.0055, Fig. 7D ), with a 3.4-fold increase in myelofibrosis vs. controls.

The up-regulation of RAB5A levels between each patient’s primary tumor and node metastasis is also highly significant when calculated with the Wilcoxon signed-rank test (P = 0.0055).

We detected a highly significant ( P = 0·0055) differential occurrence of the C/C homozygous (HOM) genotype in 77·7% of ONJ cases (7/9) versus only 10% of controls (1/10) ( Fig 1A ).

Colonies differed significantly only in their inbreeding coefficients F IS , with Gannet having the highest value, and Coats the lowest, and the difference between these two colonies with extreme values was highly significant (one‐tailed t ‐test, p = 0.0055).

The expression levels of TH2B was highly significant compared to fertility score in the high fertility group ( P = 0.0055; y = −12.3828 × + 56.9464) but no significance was found in the low fertility group (Fig. 2 ; y = 2.0450 × + 28.0499).

Correlation between XCL1 expression and the presence of CD8+ DCs was also highly significant (p = 0.0055, R2 = 0.443) ( Figure 3E ).

The ANOVA of the quadratic regression model showed that this model was highly significant ( p = 0.0055).

Analysis of the amount of variance explained by location was conducted, and most locations did not have significant differences in exposure ratings, while jobs had highly significant differences ( P < 0.0056) compared with location differences ( P < 0.05), suggesting a weaker effect of location in the analysis.

In contrast, for HLA-J mRNA there was a highly significant negative association between HLA-J mRNA expression levels and tumor regression grade (ρ: − 0.6094, p = 0.0056).

A highly significant difference (p = 0.0056) was observed in two groups with higher butyrate levels associated with a significant decrease in K8 staining.

The SatScan also revealed one marginally significant ( p = 0.0056) time-space hotspot in cattle between 20/10/2022–20/03/2023 in southern Laos (106.062 N,14.7513 E) with a radius of 0.49 km ( Fig. 2 ). 4 Discussion In this study, we found that among livestock tested across the 18 Lao provinces, the prevalence of rickettsial seropositivity was low (<10%).

The reduction in the orbital volume by insertion of a titanium mesh was statistically highly significant ( p = 0.0056) in contrast to the volume change with a PDS foil ( p = 0.0422), which was at the border of statistical significance.

We found that across all investigated bacterial species there are highly significant negative correlations between AAI and genomic fluidity ( table 1 , P ≪ 0.001, for all comparisons, excluding Haemophilus influenza for which P = 0.0056, according to a Spearman correlation test).

Furthermore, adding 10 μL of αB7-H3-αCD3 BITE supernatant into PHA-L-activated T cells at E:T ratio of 10:1 resulted in highly significant cytotoxicity against L-363 (B7-H3 medium ; Fig. 8 C) and KMS-12-PE (B7-H3 high ; Fig. 8 D) cells, with percentages of 55.0 ± 5.2% ( p = 0.0056), 32.7 ± 4.4%, and ( p = 0.0067) compared to the negative controls (33.4 ± 2.0%, and 6.7 ± 3.0%, respectively).

While TIGIT + CD3 + T cells exhibited a borderline significant decrease from diagnosis to remission, the relapsed patients consistently showed an increased proportion of TIGIT + CD3 + T cells compared to the CR patients ( p = 0.0056, Figure 2 E).