Excerpts

As indicated in Figure 3 , the mean statistical values for the contrast threat minus neutral anticipation in GAD patients as compared to HC extracted from the overlapping cluster of all significant Sustained Response GLMs, followed a highly significant quadratic function with the delay of the sustained response predictor (function: y = −0.022 x 2 + 0.297 x + 2.291, R 2 = 0.96, P < 0.007).

We again observed a weak negative but highly significant correlation between age and gHFI burden ( r = −0.031, P = 0.0070).

Fisher’s exact test shows a highly significant association (two-sided p = 0.007, one-sided p = 0.0035 testing enrichment of KRAS mutations in REG4 positive regions) (Fig. 4f ).

Highly significant season effects were observed for relationships between Mg excretion and per cow milk production ( p = 0.007) with weaker relationships observed for the other characteristics (0.013 < p < 0.046).

After 30 days implantation, T concentrations showed an increasing trend but were only different between the control group (0.28 ± 0.02 ng/mL) and the 25 mg/kg group (0.85 ± 0.15 ng/mL, P = 0.007) and not with the 5 mg/kg group (0.52 ± 0.07 ng/mL, P = 0.126) ( Figure 5A ).

Regarding the severity of periodontal parameters vis-à-vis the presence of anti-CCP antibodies, a highly significant association ( p = 0.007) was observed between the mean PI and anti-CCP positivity after resulting in an adjusted OR of 1.033 (95% CI, 1.009–1.058).

For linear distance, the reduction in total distance between the knot tying mid- and post-training did not reach statistical significance ( p = 0.007).

The cortical coherence of gamma bands between the precuneus and PCC (precuneus-PCC) showed marginally significant difference ( Z = −2.42, p = 0.007, adjusted p = 0.068), suggesting a stronger functional connectivity in the Asy condition.

Patients with MAPT mutations showed a trend towards more severe atrophy in left entorhinal cortex (U = 2.0, z = −2.68, p = .007) and fusiform gyrus (U = 1.5, z = −2.72, p = .006) and right perirhinal cortex (U = 1.5, z = −2.67, p = .007) than patients with mutations in the GRN and C9orf72 gene and in right fusiform gyrus compared to bvFTD patients with no gene mutation (U = 13.0, z = −2.80, p = .005). 4 Discussion In this large cohort of bvFTD patients naming problems were a prominent feature of many, although not all, patients (around 50%).

In colorectal cancer, the rate of TOP1 CNG has been reported to range from 53 to 84% [ 26 , 27 ]; moreover, in a metastatic setting, a borderline significant association ( p = 0.007) between an increase in the TOP1 CN and an objective response to second-line treatment with irinotecan monotherapy has been reported [ 28 ].

post DRibble-specific responses was highly significant (p=0.007).

During the 2007–2016 decade, the overall unadjusted suicide mortality rates showed a significant trend to decline over time ( r = −0.78; p = 0.007) and ranged from 3.1 in 2015 to 4.7 in 2008.

For T4 lesions, the range was 1–4 cm with 49% of MUs performing a 2-cm margin (with highly significant differences between groups: 52% of AMs, 15% of PMs and 42% of FMUs, P = 0.007), 90% of MUs from 2 to 4 cm (38% of the AMs, 40% of PMs, and 53% of FMUs).

However; there was one statistically significant difference at 6 months (MD=−0.08), although this is not clinically relevant and can only be considered of borderline significance (95% CI –0.13 to –0.02), despite the low p value (p=0.007), see figure 2 d2 .

On average, participants with cotinine levels ≥3 ng/ml had telomeres that were shorter by approximately 92 bp (β: −92.40, 95% CI: −150.99 to −33.81, p -value <0.01) compared to those with cotinine levels <0.05 ng/ml category, with a significant trend across the exposure categories, suggesting a dose-response phenomenon (for the trend across cotinine categories, p -value = 0.007).

The two PGT groups showed a trend towards a lower risk of miscarriages compared to the ICSI group (13.7% vs. 7.3% vs. 27.9%, p = 0.007).

When we combined the heterozygote AG and homozygote AA as a pooled risk genotypes comparison group, assuming a dominant effect of the variant A allele, the combined genotype XA (AG+AA) was associated with a highly significant 56.4% increased risk of higher Gensini score ( p = 0.007, OR = 1.564, 95% CI = 1.132∼2.162) relative to the GG genotype.

The difference between the onset age of males and females did not reach statistical significance except in the group with limb dystonia ( p = 0.007).

As shown in Fig 6 a highly significant negative correlation was observed among CFA positive children born to infected mother (r = -0.79, p = 0.007; Fig 6A ).

The Spearman correlation analysis showed a moderately significant negative correlation between VDI and SF-36 subcomponents ‘energy fatigue’ (rho=-0.484, p = 0.007) and ‘general health’ (rho=-0.411, p = 0.024).

In normal pregnancy, during labour, ( Fig 3A ) there was no significant change in sFlt-1 levels at full dilatation, although an increasing trend was noted it probably did not achieve statistical significance due to small sample size SFlt-1 levels significantly decreased after 24 hours (82% p<0.007) of delivery.

When analysing the duration until initial authorisation of a clinical trial application (CTA) over the last 10 years, it became obvious that there was a significant trend towards shorter approval times for non-integrated protocols ( r = − 0.76; p = 0.007, Fig. 4 a).

Histology had a significant impact on local tumor control ( p = 0.039), showing highly significant differences between patients with prostate cancer and “other” (see patient characteristics, p = 0.007).

In summary, when accounting for known moderating factors of age, gender, BMI, and hydration, there was a highly significant association between antigen positivity and increased Indurometer measures at the non-dominant calf ( p = 0.007).

The improvements in both unilateral and bilateral CLP patients were highly significant (p = 0.007; p = 0.001; respectively).