Excerpts

While two of the 13 DMPs at birth also showed nominally significant effects at age 7 (cg27469152 located in the gene EPX ; β stdn = -0.090; p = 0.008; and cg16290904 located in the gene PEX2 ; β stdn = -0.077; p = 0.022; Table 1 ), no probe remained significant after FDR-correction for 13 test.

When comparing early stage (1 and 2) and advanced stage tumors (3 and 4), we found that loss of cytoplasmic CDK1 was borderline significant for early stage tumors ( p = 0.063) but highly significant for late stage tumors ( p = 0.008) ( Figure 4C and Table 2 ).

A highly significant difference (TOC higher when compared to TATE) was found for primary tumors ( P = 0.008), liver ( P = 0.000) and lymph node ( P = 0.000) metastases, while uptake of 68 Ga-DOTATOC was significantly higher in bone metastases ( P = 0.011).

Both groups exhibited implicit adaptive salience (see Table 1 ), though this effect was only marginally significant in the TRS group [controls: mean = 8.85 ms, SD = 17.34 ms, t(30) = 2.841, P = 0.008; patients: mean = 12.28 ms, SD = 24.87 ms, t(17) = 2.093, P = 0.052].

Significant decrease in fold changes of miR-21 occurred in CR patients whereas an increasing trend occurred in PR and PD patients (p = 0.008, Table 5A ).

Adjusting for baseline characteristics yielded a 12% reduction in risk of death or nonfatal cardiovascular events (relative hazard 0.88, 95% CI 0.79 to 0.97) that was nominally significant ( P =0.008).

When partitioned into low (n = 16) and high (n = 17) reactive groups, the high reactive group showed a highly significant decrease in SBR during the IT period compared to baseline (11.1 ± 1.09 blinks per min to 6.2 ± 0.95 blinks per min, t 1,30 = − 2.9, p = 0.008) and a significant increase in SBR from baseline during the CT period (11.1 ± 1.09 blinks per min to 15.6 ± 1.71 blinks per min, t 1,30 = 2.7, p = 0.012).

When the prevalence of asthma was estimated only among patients with COVID-19 ( Table 2 ), a significant trend was observed, both in children and adults, with decreases in the asthma prevalence rates in waves II (odds ratio [OR], 0.74; P = .008; OR, 0.73; P < .001, respectively), III (OR, 0.62; P < .001; OR, 0.58; P < .001, respectively), IV (OR, 0.68; P < .001; OR, 0.70; P < .001, respectively) and V (OR, 0.53; P < .001; OR, 0.62; P < .001, respectively) compared with those in wave I ( Table 2 ).

The p-values of coefficients for these three variables were highly significant (p ≤ 0.008), and thus we presume the regression model to be valid.

4 , there was a nonsignificant trend for the empirically determined DGRD to correlate with age ( r 2 = 0.27; P = 0.008).

ANCOVA, with the CV as dependent variable, sample date as a random factor, and colony size as a covariate, showed no interaction between covariate and sample date ( F 1,8 = 2.33, P = 0.165), but a highly significant effect of colony size ( F 1,8 = 12.38, P = 0.008).

The mean ± SD of the differences in the BI recovery points measured with the two smooth tests of -1.86 ± 4.69 PD ( Fig 5B ) were at the limit of significance considering the adjusted significance level ( t (48) = -2.78, p = 0.008, Cohen’s d = 0.39).

Peak SpO 2 fell within normal values for all groups, although a significant trend in progressive reduction was found between groups (97.7 ± 1.1% vs 97.6 ± 1.2% vs 96.8 ± 1.7% among ND, ERA and LSRA patients, respectively; p = 0.008).

This also led to similar conclusions with a highly significant interaction between time and treatment for CFQ (p = 0.008) and similar estimates for change from baseline to 3 months (−5.5 [-10.1,-0.9] and −17.2 [-22.6, −11.8] in intervention and control group respectively). 5.

Notably, rs192471919 had a nominally significant association ( P = 0.008), with same effect direction in Jansen et al. 3 where it was present only in the PGC-ALZ cohort (n = 16,350).

The rate of change was more than double for lateral-midline electrode position compared with rostro-caudal position, and this difference was highly significant ( P = 0.008, n = 9).

A change in the total medical imaging cost for the breast cancer patient claimed every month showed an increasing trend before the amendment (β = 5,475, standard error [SE] = 1,992, P = 0.008) and rapid change immediately after (β = −103,317, SE = 16,152, P < 0.001).

In patients with poor glycemic control (aBG > 180 mg/dL), the mortality risk was higher than in those without diabetes but did not reach statistical significance after adjustment (unadjusted HR: 1.95 [1.19–3.20]; p = 0.008; adjusted HR: 1.58 [0.95–2.65]; p = 0.080).

With regard to unique predictors of change in outcomes, similarity of offender spirituality was the most consistent predictor showing significant, negative associations with growth in unforgiveness, emotional expressivity, and self-esteem (βs = −0.17 to −0.42, p s ≤ 0.005) and significant, positive associations with empathy (β = 0.40, p = 0.002), and positive affect (β = 0.46, p < 0.001) and a positive association that approached significance for emotional forgiveness (β = 0.32, p = 0.008).

Most participants agreed that it is: for example, 72% of participants agreed or strongly agreed with the statement, “Learning is due to modifications in the brain”; and 90% agreed or strongly agreed that, “There is a lasting change in the brain when someone learns a new skill.” Using the Bonferroni-adjusted alpha level of 0.006, we found that the correlation between TOI scores and responses to these questions did not reach statistical significance ( R 2 = 0.036, p = 0.008).

Analysis revealed that the coexistence of neck and radicular pain was a highly significant predictor of symptom recurrence (95% CI, p = 0.008).

Although not surviving multiple testing, a nominally significant association was found between salt intake ≤6 g/day and presence of chronic axonal polyneuropathy (OR = 0.55, 95% CI 0.35; 0.86, P = 0.008).

Permeability determined with the in vitro iPSC-hBBB model showed a highly significant correlation with the in vivo K 1 (R 2 = 0.83; P = 0.008; Fig. 5 ).

Another strain, B6-Chr5 A/J (CSS-5), approached significance at P < 0.008.

The combined odds ratio was 1.35 (1.08–1.70), with a highly significant P = 0.008.