Excerpts

Results indicate that across three subgroups, targeted drugs (TD) showed a significant trend toward reducing recurrence risk, with a pooled odds ratio of 0.19 (95% CI [0.06, 0.65]), reaching statistical significance (P = 0.008); induction chemotherapy (IC) had a pooled odds ratio of 0.75 (95% CI [0.55, 1.02], P = 0.07), which was not statistically significant but suggested a potentially beneficial direction; while radiotherapy (RT) showed a pooled OR of 1.83 (95% CI [1.05, 3.18], P = 0.03), statistically significant but with an effect direction suggesting this intervention may increase recurrence risk.

While the KD and SD group displayed no significant effect of diet type on creatinine, glomerular filtration rate (GFR), and uric acid in, the LCD group experienced a significant decrease in creatinine, an almost significant reduction in uric acid ( p = 0.008), and a significant increase in GFR.

At 12 months, the GLP-1 cohort demonstrated a highly significant increase in the RD of 0.014 with a 95% CI of 0.004 to 0.024 in nonunion/malunion compared with the control group ( P = .008) ( Table 3 ).

A notable trend was observed with growth factors: Angiopoietin-1 (ANG-1) was significantly upregulated in both the 500 mW/cm 2 ( p = 0.008) and 1000 mW/cm 2 ( p = 0.039) groups.

Time 5 reinforces a decreasing trend (p = 0.008).

There was a highly significant ( P = 0.008) improvement in survival on day 180 in the day 1–3 plus day 31–45 treatment groups (60% versus 10% in the control group).

In the full sample (V versus NV), the analysis revealed a single highly significant CCA mode that related brain connectomes to subject measures ( r = 0.94, p = 0.008).

Notably, the highest MCMI quartile still showed borderline significant heart disease risk in Model 3 (HR = 1.29, p = 0.008), implying MCMI captures unique metabolic dysregulation patterns/synergistic effects not fully reflected by individual traditional indicators.

Adaptive cognitive emotion regulation strategies (CERQ_ad) showed a trend ( p = 0.008) but did not meet the corrected threshold.

The antibiotics with low resistance rates were aminoglycoside antibiotics, which were gentamicin (4.4%), tobramycin (4.3%), and amikacin (1.4%), but amikacin showed an increasing trend year by year ( p = 0.008).

This effect approached but did not reach significance after correction for multiple comparisons ( t (62) = 2.73, p = 0.008).

The Bonferroni post-hoc test revealed a significant difference between S1 and S3 ( p = 0.014), and a highly significant difference between S2 and S3 ( p = 0.008) ( Figure 2 ).

Age was associated with declines in recognition scores [ r = −0.36, t (193) = −5.36, p < 0.0001], and older participants showed a trend toward reduced learning rates [ r = −0.19, t (193) = 3.90, p < 0.008].

Both the EFS and OS were highly significant across the three risk groups ( p = 0.008 and p = 0.004, respectively).

+ Vitamin D Tier (Full VDIBS): AUC 0.78 (95% CI 0.73–0.81) ○ Incremental benefit: ΔAUC = +0.05 (95% CI +0.02 to +0.08, p = 0.004); ○ Likelihood ratio test: χ 2 (1 df) = 8.4, p = 0.004 (highly significant); ○ Net Reclassification Improvement: NRI = 0.12 ( p = 0.008); ○ Integrated Discrimination Improvement: IDI = 4.2% ( p = 0.012).

Although the MR Egger (bootstrap) analysis showed a borderline significant positive association ( β = 0.052, 95% CI = −0.004 to 0.104, p = 0.008), this finding is not conclusive, given that its confidence interval contains zero values and is inconsistent with the results of other analytical methods.

From the Kruskal-Wallis and Dunn post hoc tests, we have found that the difference between the d-spacing of the EMT positive lesion and non-lesional tissue is highly significant (p < 0.008).

5 b), the vast majority (17 of the 20 (85%) women in the mifepristone group) exhibited a highly significant reduction in the luminal progenitor cell fraction regardless of BRCA mutation carrier state ( p =0.008; Fig. 5 e).

However, we observed a tendency ( P = 0.09) toward an increase in UCP5 mRNA levels in the fructose offspring compared with control, and interestingly, we found a highly significant inverse correlation between UCP5 mRNA levels and the P/O 2 ratio ( P = 0.008) ( Figure 2B ).

The statistical strength of the relationship between number of spike/m2 of broomrape and the reduction in various faba bean yield and yield components traits (R2>0.5 in all cases, most exceeding 0.85), extremely significant p-values ( p ≤ 0.008), and biological plausibility combine to prove that broomrape spike density is a primary determinant of yield reduction in faba bean, primarily through its impact on pod number.

To eliminate possible discrimination due to outliers, a Spearman’s test was performed, confirming a highly significant correlation with β2M ( p = 0.008), plasma cell percentage ( p = 0.035), C-reactive protein ( p = 0.043), and serum calcium levels ( p = 0.038), as shown in Figure 3 A.

This difference was statistically highly significant according to the log-rank test ( P = 0.008).

Bound urea nitrogen increased significantly in the LCD group, and almost significantly ( p = 0.008) in the KD group.

With regard to unique predictors of change in outcomes, similarity of offender spirituality was the most consistent predictor showing significant, negative associations with growth in unforgiveness, emotional expressivity, and self-esteem (βs = −0.17 to −0.42, p s ≤ 0.005) and significant, positive associations with empathy (β = 0.40, p = 0.002), and positive affect (β = 0.46, p < 0.001) and a positive association that approached significance for emotional forgiveness (β = 0.32, p = 0.008).

While two of the 13 DMPs at birth also showed nominally significant effects at age 7 (cg27469152 located in the gene EPX ; β stdn = -0.090; p = 0.008; and cg16290904 located in the gene PEX2 ; β stdn = -0.077; p = 0.022; Table 1 ), no probe remained significant after FDR-correction for 13 test.