Excerpts

The δ 13 C otolith−growth showed an increasing trend with increasing water temperatures ( r 2 = 0.460, p = 0.008; Fig. 4 b).

Among the biomarkers evaluated, only pre-PCI neopterin level showed a weakly significant correlation with the absolute volume of the necrotic core (r=0.320, p =0.008).

When the three APG subsets were analyzed separately, TAP α diversity was explained by both MHC-I ( P = 0.008 for both amino acid p -distance and Grantham distance, the effect for synonymous divergence was marginally nonsignificant) and non-APG α diversities ( P ≤ 0.002 for all three distances).

Interestingly, despite the fact that the actual target of selection is not known, the clinal frequency change is highly significant ( p < 0.008) based on Student’s t test for 10,000 random sets of SNPs generated by jackknifing 21 SNPs out of the 197 SNPs segregating in the region of interest (3R: 4,239,638-4,271,390, Additional file 1 : Figure S15).

Notably, rs192471919 had a nominally significant association ( P = 0.008), with same effect direction in Jansen et al. 3 where it was present only in the PGC-ALZ cohort (n = 16,350).

With a highly significant pathological complete response of 49% (versus 23% in AC patients; p = 0.008) and estimated 5-year survival benefit from combination chemoradiotherapy compared to surgery alone (AC: p = 0.049; SCC: p = 0.011), it is evident that this patient subgroup had a major benefit from this therapeutic intervention [ 10 ].

Two-way ANOVAs revealed a highly significant FEMALExSTIMULUS interaction in almost all the regions analyzed: PrL-IL (F 1,26 = 8.341, p = 0.008; see Figure 3 A); BLA (F 1,26 = 23.660, p < 0.001; Figure 3 B); AcbSh (F 1,26 = 18.882, p < 0.001; Figure 3 C); AcbC (F 1,26 = 56.418, p < 0.001; Figure 3 D); VTAp (F 1,26 = 15.897, p < 0.001; Figure 3 F).

The decrease in NIHSS on day 5 compared to day 1 was highly significant in patients with ischemic stroke (mean change −0.447, P = 0.008) as compared to hemorrhagic stroke (mean change −0.370, P = 0.096).

T234_clearance rate was higher in pCR patients ( P = 0.02; Fig 2C ), and similar results were seen when grouping patients by their tumor regression grades, with T234_clearance rate showing a decreasing trend from complete regression (pTRG0) to poor regression (pTRG3) (95.7%, 77.8%, 71.1%, and 66.7% in pTRG 0, 1, 2, and 3 groups, respectively, P = 0.008; Figs 2D and S3A ).

Additionally, in NAS score analysis in this region, we detected a novel eQTL marker for HSD17B13 (rs3923441) that was nominally significant with NAS score ( p = 0.008, beta = 0.55) (Additional file 1 : Table S3) and produced a PheWAS effect for abnormal liver enzyme levels (see the “ PheWAS approach ” section).

And there is a decreasing trend in the IAC of meropenem (coefficient = −0.03, p = 0.008) in all departments.

This effect approached but did not reach significance after correction for multiple comparisons ( t (62) = 2.73, p = 0.008).

The data show a decreasing trend in reaching ambulation among patients operated after 48 h from admission, with a statistically significant association ( p = 0.008, Pearson correlation coefficient).

In EAS, the proportions of selection increased from a significant underrepresentation at the very periphery of the network (BC = 0; nominal P = 0.001, FDR corrected P = 0.007) to a marginally significant overrepresentation with high BC scores of 2,001–20,000 (nominal P = 0.008, FDR corrected P = 0.025).

The effect of probucol therapy on long-term survival following complete revascularization was also reported in 1,694 patients after complete revascularization with PCI and/or CABG by a propensity score analysis 45 ) , in which the use of probucol was associated with a markedly significant decrease in all-cause death in a propensity score-adjusted model (hazard ratio = 0.57; p = 0.008).

In detail, the intensity of tumoral HLA-I HC/β 2 -m surface expression correlated highly significant positively with the density of intra-tumoral CD8 + T cells ( p = 0.008 resp. 0.003), but negatively with the number of CD8 + T cells adjacent to FoxP3 + cells within a radius of 30 μm ( p = 0.009 resp. 0.007) ( Table 5 ).

Significant decrease in fold changes of miR-21 occurred in CR patients whereas an increasing trend occurred in PR and PD patients (p = 0.008, Table 5A ).

The results revealed that treatment of lean adipocytes with 1.0 μM insulin for 1 h stimulated a highly significant (P = 0.008) ~ threefold increase in ADH1B activity compared to untreated control, indicating insulin-induced ADH1B expression results in a proportional increase in activity (Fig. 7 ).

All groups’ PPARγ expression showed a decreasing trend, among which, PPARγ of the IHT group significantly reduced (baseline vs. postexercise: 9.87 ± 2.79 vs. 8.12 ± 1.37, p = 0.008).

The results were found to be highly significant ( P = 0.008), as shown in Table 1 and Figures 4 – 6 .

The difference between the groups is highly significant ( p = 0.008).

This trend is statistically highly significant (χ 2 = 7.045, p = 0.008) ( Figure 1 ).

By the period of 2004–2008, significant RER’s continued to exist for, stomach, colorectal, liver, lung, breast, prostate cancers, while RER variations in cervical and uterine cancers became highly significant ( p = 0.008 and 0.001 respectively).

In the 2-year study period, the overall hospital-wide HAI prevalence showed a decreasing trend (p = 0.008).

Whereas for all mice no associations were observed for microglia activity and behavioral performance, when focusing on only the 12-month-old vaccinated mice and their mock controls, a highly significant correlation was seen between hippocampal microglia activity and AUC of the MWM learning curve ( r = 0.78, p = 0.008), which could completely be attributed to microglia activity in the Hilus ( r = 0.93, p < 0.000).