Barely Significant

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almost reached significancep = 0.0080.2× alpha
This difference was significant at the ages of 12 and 24 months, as well as at the age of 6 years, and almost reached significance at the age of 6 months and 10 years (28 vs. 35°, p = 0.008; 28 vs. 35°, p = 0.002; 28 vs. 34°, p = 0.001; 28 vs. 36°, p = 0.056 and 30 vs. 36°, p = 0.075, respectively).
a significant trendp = 0.0080.2× alphagold
The difference between HR-noASD and ASD subjects in the number of transitions from face to target object was significant ( p = 0.016), whereas there was no significant difference between TD and HR-noASD groups ( p = 0.11). A significant trend in the same direction was detected for the number of transitions from the non-target object to face ( p = 0.008) as well as from the target object to the non-target object ( p = 0.015) when HR-noASD subjects were compared with the TD population.
a positive trendP=0.0080.2× alphagold
Although we had only summary data (hence limited ability to show trends reliably), we saw some suggestion of a positive trend between the size of the relative risk for smoking one cigarette per day and the last calendar year of follow-up for each study: Spearman’s correlation 0.51 (P=0.008) for men and 0.21 (P=0.42) for women when we used studies of coronary heart disease, and 0.23 (P=0.39) and 0.56 (P=0.11) among men and women for studies of stroke.
highly significantP=0.0080.2× alphaqualifiedgold
In post hoc secondary analyses, similar results were found using ANCOVA with baseline score as covariate, except that the difference between groups in SPARCC MRI spine index (23-DVU) at week 6 was highly significant when using ANCOVA (P=0.008) ( figure 3 ).
an increasing trendp = 0.0080.2× alphagold
The segmented regression analysis (Figure 2 ) indicated no significant trend between PHQ‐9 score and BMI z ‐score when BMI < 2.68 (99.6th centile), but an increasing trend was observed when BMI z ‐score ≥ 2.68 (99.6th centile) (slope before breakpoint = 1.11 vs. after breakpoint = 12.89, p = 0.008).
highly significantp = 0.0080.2× alphaqualifiedgold
Yet, we found a highly significant upregulation of IL6 expression at 3 and 6 h after stimulation in both high-dose poly(I:C)—(Tukey HSD: 3 h, p = 0.008 and 6 h, p = 0.001, respectively; electronic supplementary material, table S12) and low-dose poly(I:C)—(Tukey HSD: 3 h, p = 0.013 and 6 h, p = 0.003, respectively; electronic supplementary material, table S12) treated birds compared to controls (MAM5: interaction treatment: time, p << 0.001; table 1 ; full model 5 in the electronic supplementary material, table S11; and figure 3B ).
approached significancep = .0080.2× alpha
In the full model, there were no significant interactions between either sex or FSM and any of the predictor variables at the p < .005 level, although the interaction between sex and active prototype similarity approached significance (β = −0.11, 95% CI −0.19 to −0.03, p = .008): the positive relationship between change in prototype perception and change in physical activity was stronger for boys than girls.
a notable trendp = 0.0080.2× alphagold
The risk of hypertension was significantly higher in the highest tertile of DMA concentration when compared with that in the lowest tertile before the adjustment (OR: 1.812, 95% CI: 1.166, 2.817), with a notable trend of increasing hypertension risk along with increasing level of urinary DMA concentration ( p = 0.008).
highly significantP = 0.0080.2× alphaqualifiedgold
However, we observed a tendency ( P = 0.09) toward an increase in UCP5 mRNA levels in the fructose offspring compared with control, and interestingly, we found a highly significant inverse correlation between UCP5 mRNA levels and the P/O 2 ratio ( P = 0.008) ( Figure 2B ).