Excerpts

Quantitation of patterning levels confirmed that this difference is highly significant ( p ≤ 3.7 × 10 −4 ).

Introducing all two-way interactions markedly improved model fit (G 2 = 2.42, df = 1, p = 0.119), and the likelihood-ratio comparison against the main-effects model was highly significant (ΔG 2 = 18.37, Δdf = 3, p = 0.00037).

MR associations between genetically proxied GP6 and overall stroke risk and ischemic stroke risk showed the same direction as cardioembolic stroke but did not reach statistical significance after multiple testing correction (OR wald ratio , 1.63 [95% CI, 1.25–2.13]; P =3.7×10 −4 ; FDR=0.22; Figure 2 ; Table S3 ).

Total chiasma frequency among linearly and among convergently oriented trivalents was compared by means of an ANOVA and differences were highly significant (p = 0.000374).

A moderate association was detected between rs3825214 and AF ( P adj = 0.036, OR = 0.79) and a highly significant association was detected between the G allele of rs3825214 and lone AF ( P adj = 0.001, OR = 0.65; genotypic P = 3.75×10 −4 with a dominant model).

A one-way ANOVA with Tukey’s post hoc test of ethanol concentration at the end of fermentation determined that ethanol production showed highly significant differences ( p = 0.000376).

Highly significant p values were obtained for rs17035816 ( p = 3.8 × 10 −4 ) and rs7688285 ( p = 7.6 × 10 −5 ) in GLRB .

Our results revealed highly significant synergistic genetic interactions between neb and polo for both symmetric cell divisions and earlier cell divisions ( P = 3.89 × 10 −4 and P = 1.00 × 10 −6 , respectively), but no significant interactions in the case of asymmetric cardiac progenitor cell divisions ( P = 0.117) (Figs. 5 a,d,e, 6 b, Supplementary Table S1 ).

The DRD2 (Dopamine receptor D2)-variant (rs6277) was highly significant where the C-allele displayed a protective effect towards overweight development (OR: 0.79, 95% CI: 0.69–0.90, P = 3.9x10 -4 , adj.

In addition, similar and all highly significant ( p ≤ 3.9 × 10 −4 ) Pearson correlations were found between all three housekeeping genes; GAPDH, HBB, and ACTB, for all collection volumes ( Figure A3 ).

Precisely, PAL was more correlated with the non-reducing sugars ( R 2 =0.9767, p =0.0002) than reducing and total soluble sugars, while anthocyanin exhibited a highly significant correlation with non-reducing sugars ( R 2 =0.969, p =0.0004) and total soluble sugars ( R 2 =0.9686, p =0.0004) compared to the reducing sugars.

When comparing BMI and new BMI, we found this ratio to be statistically highly significant with linear regression nBMI/ABSI ( P =0.0004).

However, several lines of evidence point to an effect of the lower dose on exercise endurance: (i) tiotropium/olodaterol 2.5/5 μg significantly improved EET during CWRCE compared with placebo in both MORACTO ® studies [26.5% ( p < 0.0001) and 12.1% ( p = 0.0003)]; (ii) there was a nominally significant improvement in EET during CWRCE after 6 weeks (22.1%, nominal p = 0.0004) in the present study; (iii) in post hoc analysis, change from baseline in EET during CWRCE after 6 and 12 weeks was nominally significant.

The ER expression of adenomyotic foci in relation to functional and nonfunctional ovarian cysts was statistically highly significant ( p =0.0004).

Vgll3 -mediated effect on age-specific mortality rate A survival assay revealed reduced lifespan in vgll3 Ex1/Ex1 mutants, highly significant in males and with a more modest effect in females (log-rank: males, p = 0.0004, −15% in median lifespan; females, p = 0.044, −7% in median lifespan, Fig. 5d ).

AA) further supported this finding, showing a highly significant risk elevation (OR = 2.85, P = 0.0004), and the MTHFR C allele itself exhibited the strongest allelic association observed (OR = 2.17, P = 0.0004).

In the univariate Firth model ( n = 35), ACE2 remained a highly significant predictor of breast cancer status (OR = 138.05, 95% CI: 4.80–14,817.63, p = 0.0004, AUC = 0.8339, 95% 99CI: 0.693–0.975).

GFP lo cells appeared reduced in gata2a um27/+ embryos at 56 hpf, however, this did not reach statistical significance when compared to WT ( Figure 2H ), nonetheless, Pearson’s correlation again suggested a contributing effect across genotypes (Pearson r = − 0.55, p = 0.0004).

This difference was highly significant ( P = 0.0004); the average distributions were 64% ±17 gametocytes in the BM and 8% ±9 gametocytes in the PB (Fig. 3b ).

The conditional sums of squares of E a estimates revealed highly significant interspecific differences in the temperature dependency of both GP max ( F = 4.4; P -value = 0.0004) and NP max ( F = 8.4; P -value < 0.0001).

There was no difference in the slopes ( P = 0.58), but the difference in elevation was highly significant ( P = 0.0004), indicating that WT and M/Mt-CK −/− hearts do not share the same relationship for d P /d t max versus heart rate, but instead run in parallel (i.e. for any given heart rate, d P /d t max is lower in M/Mt-CK −/− hearts).

For example, SOLVE identified a highly significant association between GRB7 expression and sensitivity to the drug Erlotinib ( P = 4e-4 for SOLVE vs. .98 for CATE).

2 ( a ) was highly significant ( p = 0.0004).

Self-reported engagement in muscle-strengthening exercise showed a similar pattern, with highly significant differences at all three follow-up times (p=0·0004, p=0·0004, and p=0·0006).

For the primary motor outcome, the MDS-UPDRS Part III, the LMM revealed a highly significant main effect of Time (F(2,36) = 9.54, p = 0.0004), indicating overall motor improvement in both treatment groups.