Excerpts

Given the large population, this difference was highly significant (p = 0.0007).

The differences were highly significant at both 12 (P =0.0007) and 24 (P = 0.0115) weeks between the two groups.

Results There was a highly significant positive correlation between the two sets of antibodies ( r s = 0.621; P = 0.0007).

When applying the CV mortality results in univariate Cox regressions, we observed a highly significant risk reduction resulting from supplementing the participants with selenium and coenzyme Q10 for four years, also after 12 years (HR:0.58; 95%CI: 0.42–0.79; P<0.0007).

Rs1017 was highly significant in a log additive model, with an 81% increase in risk associated with each additional copy of the T allele (OR = 1.81, 95% CI 1.29–2.54, P = 0.0007).

Although of borderline significance and hypothesis generating, after correction for the 90 TFs assayed, there was evidence for enrichment of SPI1 (alias PU.1), ( P =0.0007, P adjusted =0.063), which regulates PRDM1 and its downregulation is required for MM cell growth 19 .

The number of ROI-ROI combinations detected in the actual data (53/504 tests) is highly significant ( P < .0007) and shown as a vertical dashed line for reference.

There was an increasing trend in the number of reported cases (Spearman r = 0·7943, p = 0·0007).

Quantitative analyses confirmed that the Mrp2 immunogold labelling density in Wortmannin-inhibited samples remained as high as in controls despite insulin stimulation, while insulin also in the new media conditions with DMSO still led to a highly significant ( P = 0.0007 vs. control and P < 0.0001 vs. insulin + Wortmannin-treated cells) decline of Mrp2 levels at the plasma membrane (Fig. 5 h).

There was also a highly significant difference in the minimum CT values between the tumor recurrence and granuloma groups (15.67±5.113 vs. −17.17±4.826, P=0.0007) and in the floating range CT values (148.00±5.471 vs. 88.11±7.671, P<0.0001), respectively.

Functional group richness had a highly significant negative relationships with latitude (P = 0.0007, R 2 = 0.7101, F = 25.49, df = 9).

The exception was in 2020, when we noticed highly significant differences in the prevalence of E. faecium and E. faecalis , in comparison to 2017 ( p = 0.0007) and 2019 ( p = 0.0008), as well as a significant difference compared to 2018 ( p = 0.09).

In contrast, En1-Cre; Srd5a3 fl/- mice showed a severe and highly significant (p=0.0007) motor coordination defect assessed with the rotarod test ( Figure 1G ).

This increase in seropositivity with age was highly significant (logistic regression p = 0.0007).

Moreover, we found a highly significant positive correlation of the network gamma oscillations (power×duration) with the SWR-area increase (R = 0.58, n = 30, p=0.0007) and no correlation with the SWR incidence (R = −0.28, n = 30, p=0.14).

The caffeine–MoCA association remained highly significant in the E3/E3 homozygous subgroup ( n = 45, p = 0.0007), demonstrating robustness to genetic stratification and ruling out confounding by APOE -related differences in caffeine metabolism or cognition.

Also, the preoperative C1-INH concentration had a highly significant effect on time to recurrence of cancer (P = 0.0007), adjusting for age and disease extent.

Using this filtration strategy that leveraged the epigenomic data derived from the CMDGA, the Variant Sifter tool returned 79 variants, including one variant (chr9:504,491:A>C) demonstrating an association with ALS based on the meta-analysis of NDKP data that is approaching significance (β = 0.238, p = 7.01e-4; Figure 6D ).

However, we noted a highly significant interaction between line and diet in terms of final body weight ( P = 7.10 –4 ), specific growth rate ( P = 8.10 –3 ) and voluntary feed intake ( P = 5.10 –7 ).

Interestingly T→C mutations show even stronger strand asymmetry among phenotypic mutations, and are over-represented to a highly significant degree in the sense strand (P = 0.00071), but are not over-represented among incidental mutations.

Further, in analyses of the GTEx (Genotype Tissue Expression) human post-mortem dataset containing samples from 53 non-diseased tissue sites for nearly 1000 individuals, we observed a highly significant correlation between GHR and MITF expression in sun-exposed (lower-leg; Pearson coefficient = 0.19, p = 0.00071) and not sun-exposed (suprapubic; Pearson coefficient = 0.25, p = 0.00011) normal human skin ( Figure 7 B).

There was no significant interaction of condition and night for the ON-OFF difference of all windows with more than two stimulations ( F cond x night (6,141.8) = 1.62, p = 0.15), the main factor condition was highly significant ( F cond(1,12.6) = 19.76, p = 7.1 × 10 −4 ) indicating that the lowSWA enhancement was persistent across 7 nights.

Subsequently, CYPRI_cor was applied to the same patient cohort and yielded markedly stronger results, showing a highly significant association with the outcome measure IMPACT_orig (SE = 0.22; p = 0.00072), suggesting that the revised score maintains and potentially strengthens the relationship between CYPRI and clinical impact ( Figure 4 ) compared to the original model ( p = 0.0267).

Additionally, the hazard ratios (HR) comparing each longer TL group to the short TL group showed a decreasing trend: HR = 0.78 (95% CI 0.68–0.90, p = 7.2 × 10 −4 ) for moderately short versus short, HR = 0.61 (95% CI 0.53–0.70, p < 2.2 × 10 −16 ) for slightly short versus short, HR = 0.46 (95% CI 0.40–0.52, p < 2.2 × 10 −16 ) for slightly long versus short, HR = 0.36 (95% CI 0.31–0.42, p < 2.2 × 10 −16 ) for moderately long versus short, and HR = 0.26 (95% CI 0.20–0.35, p < 2.2 × 10 −16 ) for long versus short.

After adjusted for covariates, the associations between methylation levels of 8 sites and IS were nominally significant, and the associations between methylation levels of CASZ1_70 (adjusted OR = 0.99 [0.98–1.00]; p = 7.26 × 10 −4 ) and CASZ1_67 (adjusted OR = 0.98 [0.98–0.99]; p = 5.54 × 10 −5 ) and IS were significant.