Barely Significant
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a favorable trend

467 sentences · 467 papers · 2,147 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

92.5%; risk difference, -5.9% [95% CI: -15.8%-3.8%]); IRC-assessed PFS was similar with a favorable trend in zanubrutinib over orelabrutinib (HR, 0.74 [95% CI: 0.37-1.47]) and the 18-month PFS rate was numerically higher in zanubrutinib (82.9% vs. 78.7%).
Age-stratified kidney outcomes were unavailable in this paper; however, overall, GLP1-RAs were associated with a favorable effect on the composite kidney outcome (21%reduction (HR 0.79 [95% CI 0.73–0.87]; p < 0.0001)), with a favorable trend for the worsening kidney function outcome (14% reduction (HR 0.86 [95% CI 0.72–1.02])).
Third, although the power analysis revealed a favorable result, further studies with a larger sample size may reveal different findings because there was a favorable trend toward the ketorolac group in this research, though it was not statistically significant.