“did not reach statistical significance”

Although recessive cases showed a trend toward greater mtDNA reduction, this did not reach statistical significance, likely because of the limited sample size.

A higher LMR (≥ 3.0) showed a positive trend but did not reach statistical significance in adjusted models.

The HR of 0.58 (95% CI, 0.33 to 1.03; stratified log-rank P = 0.057) indicated a favorable trend toward improved survival with vebreltinib, although the difference did not reach statistical significance (Fig.

A/S + 40 Hz group exhibited an increasing trend compared with the A/S group, though the difference did not reach statistical significance, while alpha coherence increased significantly.

Phosphorylated TH, phosphorylated CaMKII, and dopamine protein levels showed an increasing trend in the model group, although these differences did not reach statistical significance.

Importantly, even though the difference in OS did not reach statistical significance in the total population, a clear trend favouring the MDTc group was observed, and statistical significance was achieved in subgroup analyses suggesting a clinically relevant benefit that warrants further investigation.

Similarly, JJA sIgE levels showed a trend to be higher in subjects with LLR but did not reach statistical significance ( p = 0.14).

Age 3–17 years, tumor volume >8 cm3, and KPS 70–90 showed a trend toward association, but the differences did not reach statistical significance (HR = 2.01, p = 0.095; HR = 2.46, p = 0.087; HR = 0.50, p = 0.111) ( Figure 4 , Table 6 ).

IMP4 was significantly upregulated in GSE66407 , whereas it showed a decreasing trend in GSE179285 and GSE11223 , although the differences did not reach statistical significance ( Figure 4C ).

Regarding antioxidants, unlike bilirubin, the level of uric acid showed a trend of increasing in overweight/obese adolescents; however, it did not reach statistical significance.

While it also showed a positive trend for anxiety improvement, the between-group difference in final anxiety scores did not reach statistical significance. 85 These mixed and preliminary findings underscore that there is currently no standardized pharmacological protocol for treating anxiety in TD.

Of note, the blastocyst formation rate exhibited a decreasing trend with higher TyG quartiles; in Q4 compared with Q1, the adjusted difference was − 2.37% points (β = − 2.37; 95% CI, − 4.78 to 0.03), which did not reach statistical significance, and other quartile contrasts were likewise non-significant.

Camre-chemo also showed a strong trend toward prolonged PFS (HR = 0.31, 95% CrI: 0.06–1.66), although this did not reach statistical significance due to wide credible intervals.

Compared to the ICL group, the PSS group showed a trend toward reduced microbial diversity; however, this difference did not reach statistical significance (Shannon index: p = 0.065; Simpson index: p = 0.066).

Kaplan–Meier analysis for overall survival showed a trend toward poorer survival in the high-risk group but did not reach statistical significance (log-rank p = 0.2; Fig. 10 C).

Serum RNASE1 levels were significantly higher in patients with severe disease activity compared with those with inactive disease, whereas patients with mild or moderate activity showed a trend toward increased RNASE1 levels that did not reach statistical significance ( Figure 2C ).

Short-term fasting (≤3 days; k = 15) showed a trend toward reduced triglyceride levels (g = −0.335; 95% CI: −0.684 to 0.013), although this effect did not reach statistical significance.

Correlation of PIK3CA mutations with outcome Patients enrolled in the G3 trial who had tumours with PIK3CA mutations showed a trend towards worse invasive disease-free survival (iDFS) compared to those with PIK3CA wild-type tumours, although this difference did not reach statistical significance (HR 2.1 (95%CI 0.95–4.78); p = 0.066) (Fig. 4 ).

Although a decreasing trend was also observed throughout the entire time course also for LCAT, particularly at the 4-hour mark, this trend did not reach statistical significance (data not shown).

pqsA expression showed a decreasing trend, although this did not reach statistical significance ( p > 0.05).

Although OWDTO groups demonstrated a slight trend toward greater PTS increases, these differences did not reach statistical significance (Table 3 ).

Although the results showed a trend towards a reduction in sedentary time and an increase in MVPA when the PAL lesson was implemented, these variations did not reach statistical significance.

Additionally, a high density of CD8 + TILs at the invasive front showed a trend toward better prognosis, although this association did not reach statistical significance ( p = 0.089). 4.4.

Compared to the AD group, the levels of Tau, P‐tau, BACE1, and PS‐1 showed a decreasing trend after APS treatment and were positively correlated with concentration, although the differences did not reach statistical significance.

However, a numerical trend toward lower mortality was observed in the post-intervention group, suggesting a potential clinical benefit that did not reach statistical significance.