The rs6427528 ( CD84 ) variant showed a trend toward benefit, but this did not reach statistical significance ( p = 0.055).
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“did not reach statistical significance”
In the literature
Although their study suggested a slight trend toward greater dermal and subcutaneous thickness on the subcutaneous side, these differences did not reach statistical significance, likely due to the small sample size ( n = 6).
While the trial showed a numerical trend toward improvement in hyperphagia questionnaire for clinical trials (HQ-CT) total scores at week 13, the difference vs placebo did not reach statistical significance [ 13 ].
Therapies targeting IL-17 and IL-12/23 inhibitors also showed a trend toward reduced arthritis risk compared with TNF inhibitors, but these associations did not reach statistical significance (IL-17: HR 0.62; 95% CI 0.37 to 1.04; p=0.073; IL-12/23: HR 0.66; 95% CI 0.36 to 1.24; p=0.196).
It also showed a trend of determining a lower RFS, although did not reach statistical significance.
Albumin showed a trend toward higher levels in HCC compared with iCCA (AUROC = 0.60, sensitivity = 60%, specificity = 65%); however, this difference did not reach statistical significance ( p = 0.06; Fig. 2 A).
In our study, adjuvant radiotherapy showed a trend toward improved local control, although it did not reach statistical significance, possibly due to sample size.
The results showed a trend toward partial recovery of associative learning ability following gene therapy, though it did not reach statistical significance, likely due to inter‐animal variability and a limited sample size compared to rodent behavioral studies (Figure S10 , Supporting Information).
While some studies did not reach statistical significance, all showed a trend towards an increased risk.
a positive trendgold
An interesting finding revealed in this study was a positive trend toward an association of high immunohistochemical expression of RUNX2 with larger tumor sizes; however, this did not reach statistical significance (p = 0.749) (Table 2 ).
Within the SH-protein/TAC/TOS triad, decreasing BMI was associated with a statistically significant reduction in TAC, while TOS showed an increasing trend; however, this increase did not reach statistical significance ( p = 0.132).
The scatter plot showed a negative trend between NEDD4 and PTEN expression, although this association did not reach statistical significance (Figure 4 G).
Only the L/O ratio showed a trend toward higher values in the V-shape group, but this did not reach statistical significance.
The frequency of < 5 s long micro-arousals showed a trend towards increasing over the time course of the recovery sleep following sleep deprivation, although this did not reach statistical significance (Fig.
a clear trendgold
A clear trend in the same direction was observed for Overall Survival (15.99 vs 12.1 months), which approached but did not reach statistical significance ( P = 0.0990; Fig. 4I ), likely reflecting the limited statistical power of this smaller cohort.
The p.K687T mutation significantly decreased phosphatase activity, while another mutation, p.R15W, showed a trend toward decreased phosphatase activity that did not reach statistical significance.
The initial stage at initial diagnosis showed a trend toward imbalance, although the difference did not reach statistical significance (P=0.09).
Beyond processing speed deficits, MEL patients showed a marginal trend toward poorer executive function (SCWT) compared to NMEL patients, though this difference did not reach statistical significance after Bonferroni correction for multiple comparisons.
While a slight trend toward elevated P3 amplitude was visually observable in the ZS group, this did not reach statistical significance.
However, PD-L1 high expression group (TPS ≥50%) showed a trend toward longer survival (n=4; mPFS =15.93 months, 95% CI: 3.13–NE) compared to PD-L1-negative patients (n=11; mPFS =5.33 months, 95% CI: 4.37–NE), though this difference did not reach statistical significance (P=0.39, Figure 3D ).
Although ECOG PS showed a favorable trend in patients with scores 0–1, this did not reach statistical significance in the adjustment.
a strong trendgold
A strong trend toward a higher total postoperative complication rate was observed in the laminectomy group (n=12, 24%) compared to the laminoplasty group (n=2, 4%), though this did not reach statistical significance (p = 0.062, Fisher's exact test).
Age showed a trend toward increased risk but did not reach statistical significance.
a weak trendgold
The funnel plot ( Figure 3 ) and Egger’s test revealed no evidence of small-study effects or publication bias across all subgroups, with the exception of the DM subgroup, in which a weak trend towards small-study effects was noted; however, this did not reach statistical significance ( p = 0.0746).
The difference between SL9 and SL12 showed an increasing trend but did not reach statistical significance.