“near-significant”

This near-significant signal suggests that TXA’s hematological benefit may be more evident in larger cohorts or in patients at higher bleeding risk.

Since LH shows pulsatile secretion during the day (e.g., [ 15 ]), a half-day urine sample was collected in a subset of participants, to be analysed in the event of near-significant results on serum LH.

Additional limitations include the difficulty in diagnosing symptomatic RP in the setting of patients with underlying lung disease susceptible to community or healthcare-acquired pneumonia, general homogeneity of the studied population, lack of information on quit dates for current smokers versus former smokers, and near-significant heterogeneity of the location of treated lesions between the symptomatic RP and asymptomatic cohorts.

One-way ANOVA followed by post-hoc LSD test revealed a near-significant P value of 0.051 in comparisons of PS1 +/+ vs.

Glucose treatment resulted in a near-significant increase in OPC proliferation (SOX10+/PDGFRα+/BrdU+; Fig. 1D ).

Significance corrections like Bonferroni may be too strict; some of the near-significant pleiotropic associations may, in fact, represent genuine associations.

The near-significant Primed vs Control N1 difference deserves brief treatment.

A strong positive correlation was observed between seminal NA levels and the FSH/LH ratio, with seminal NA also showing a near-significant correlation with LH.

In addition, population trends showed a near-significant positive correlation with retrodicted trends in the suitability of the climate for each species (CST), based upon the climatic envelope models and observed recent climatic change.

Meta-regression of outcomes against demographic factors revealed only a few near-significant correlations shown in Table 10 .

We also examined changes in consumption of individual food groups in the dietary recall (online Supplementary table 5 ), noting significant increased daily consumption of legumes and vitamin A-rich fruits and vegetables and a near-significant increase in the consumption of eggs.

In this case, it appears that near-significant results from those previous studies multiplicatively combined to yield significance here.

Older age at the time of primary surgery was associated with a higher risk of reoperation (OR per year = 1.261; p = 0.024), independent of follow-up duration, which was uniform across the cohort Preoperative occlusion therapy ( p = 0.075) and age at surgery ( p = 0.055) demonstrated near-significant trends but did not meet the pre-defined significance threshold.

However, using the PathOlogist activity scores, we identified 9 significant ( q ≤ 0.05) and 31 near-significant (0.05 < q ≤ 0.25) pathways in both microarray and RNA-seq datasets.

Predictive power of ConSigs ConSigs was constructed using various combinations of components, with the starting point being components shown to have significant or near-significant predictive capability when used alone, that is, STAT1, topoIIα, HIF, and LAPTM4B.

For the gene list downregulated in T1D subjects, there was a near-significant enrichment (EASE score<0.06) of terms related to cell migration/motility , cytokine binding, MHC class II receptor activity, chemokine receptor activity , chemokine receptor & MHC Class II, alpha chain .

Analysis of Likert scale ratings across all five didactics within separate gamified and traditional cohorts demonstrated, in both cohorts, significant or near-significant increases from pre-test to post-test in ratings of confidence and knowledge of guidelines.

For both validation sets, there was either a highly significant or near-significant concordance between tumors assigned as “mir-155 positive” by the HEK293 signature and those tumors assigned as “mir-155 positive” by the gastric-derived hsa-miR-155 expression signature (p = 5.8×10−7 for glioblastoma and p = 0.06 for ovarian cancer; chi-square test) ( Table S4 ).

No significant or near-significant findings emerged among participants with HDRS scores <7.

Near-significant relationships were also observed with PTH (inversely) and u P/ u Cr (a positive association); in none of these models was country a significant predictor of 25(OH)D 3 half-life.

Even when the fraction of coupled p-MDTA allele pairs at linked microsatellites in the buffalo genome linearly decreases from a value as high as 0.8 at 24.9°S to 0.5 (expected fraction in the absence of selection) at 4.8°N, the probability of observing a significant ( α = 0.05) or near-significant ( α = 0.1) difference in average latitude with a Student’s t -test between coupled and repulsed allele pairs was only 34% and 46%, respectively (60 r LD estimates from 24 locations using 50 randomizations).

Analysis of changes in the variables showed a significant or near-significant decrease in SD; in sector analysis, the SD of changes in D 90 in the IBCL group was also significantly lower compared with the LS group.

A near-significant increase in quadriceps muscle strength was observed between T1 and T2, with a p -value of 0.08.

Table 2 outlines the probabilities of TBI in participants with abnormal BMI (≤18.5 or ≥25) (AOR = 1.87, 95% CI = 0.97–3.59), which was also positively correlated with TBI in univariate analysis and showed near-significant results in the multivariate analysis.

It was hypothesized that extending the exercise program by 4 weeks would result in sustained improvements across outcome measures, with certain measures like resting blood pressure expected to reach statistical significance at 8 weeks, based on the near-significant changes observed at 4 weeks in our previously published study (Kirk et al. 2025 ).