“near-significant”

IL-1α: 2.24 ± 0.45-fold increase, p < 0.05) and near-significant increases in perlecan transcription (Fig. 4 d) (vehicle: 1.03 ± 0.16-fold increase vs.

We found that mRNA expression of monocyte chemoattractant protein-1 (MCP-1) and toll-like receptor-4 (TLR-4) were significantly increased in FR1 mice compared with control mice, and the mRNA expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) showed a near-significant increase compared with the control.

Psychological factors like chaos and denial, which were tested for the first time in the Asian population, had significant or near-significant associations with medication nonadherence; however, some of these factors lost significance in the multivariate analyses.

These near-significant p-values reflect a weak directional trend but do not meet the α = 0.05 threshold for statistical significance—unlike the fully significant effects observed for learning motivation ( p < 0.001) and attitude ( p < 0.001), which are robust.

Slope, temperature, cos.aspect, sin.aspect, and pH were significant (or near-significant) for 16S, trn L, COI and COI-spun datasets, in addition to NO 3 and NH 4 for COI-spun.

Of the eleven ELISAs applied to the ‘discovery’ cohort (n = 47, one sample was unavailable for validation), six (NrCAM, YKL-40, chromogranin A, carnosinase I, transthyretin, cystatin C) showed statistically significant or near-significant differences between CDR 0 and CDR 1 groups ( Figure 4 ); five others (PEDF, beta-2 microglobulin, clusterin/apoJ, ceruloplasmin, apoE) did not.

Post hoc power analysis showed effect sizes (dz) of around 0.40 for near-significant findings, suggesting at least 43 subjects are needed to detect small effects statistically.

Although no significant changes were found in the topological parameters across most groups, the NS group showed near-significant trends.

alvi at LD 50 compared with LD 25 , lower Bombilactobacillus abundance in both paraquat treatment groups, and an increase in Lactobacillus at LD 50 with a near-significant difference between paraquat treatment groups.

This means that even though the three groups were statistically comparable in terms of the mood states under investigation before being involved in the mood induction procedure, the near-significant results require caution. 3.2.

Predictors of dyspnea In the initial univariate analysis, only 2 factors showed a significant or near-significant association with experiencing dyspnea.

Skin temperature was markedly increased in the hot and decreased in the cold environment, and MDMA produced a near-significant increase in skin temperature under both temperature conditions and compared with placebo. 50 Altogether, considering the pooled data analyses from our laboratory and those of the Freedman study, MDMA is well documented to produce an acute and dose-dependent elevation in core body temperature in healthy subjects.

In-depth analysis of EEG dynamics revealed a significant difference in post-stimulus alpha event-related synchronization in a fronto-central cluster and a near-significant difference at central electrodes, providing preliminary support to the inhibition hypothesis.

A near-significant association was found between incremental-GIP with decremental NEFAs that occurred during OGTT (decremental NEFAs = plasma NEFAs-at-120 min minus NEFAs-basal; rho = 0.30; P = 0.055) (Supplementary Fig.

On the other hand, vibration at IS and CM showed significant or near-significant increase of the shift of SVH in cVU ( Fig. 4A ).

Possibly, we failed to find an error rate switch cost in the MDD group because these patients tended to slow down their responses on SEs, resulting in a near-significant RT difference between MDD and controls on SEs.

The number of mice used was determined based on a pilot study showing a near-significant difference with the same treatments using three mice per group.

After stimulation with Sez6L2, we observed significant or near-significant populations of CD4 + T cells expressing IFNɣ, TNFα, IL-4, or IL-17 from both H- and M-Sez6L2 immunized mice compared to sham-immunized controls (Fig. 4 C, D).

The FAST group’s higher performance in LPRTF (early in the experimental testing session) coupled with the SLOW group’s near-significant improvement in the Wingate test (last element of the experimental testing session) aligns with this influence of the SLOW vs.

The near-significant trend between visual methods and IOCs may suggest a marginal advantage in SE for IOCs, potentially reflecting improved surface-level visualization due to digital magnification or real-time imaging.

However, given the modest sample size and near-significant between-group differences for HRV and coherence, these findings should be interpreted cautiously as hypothesis-generating rather than definitive.

This was seen for all subjects and all tested production rates (1–1.66 Hz; except for one instance in subject C where the effect was near-significant).

Although we did not have sufficient numbers of patients with post-treatment samples to attempt to analyze sex-related differences, we did observe, as previously reported in lung cancer patients ( 16 ), a significant increase in CXCL10 in non-responders while on-treatment, as well as a near-significant increase in IL-6.

Univariate analysis revealed R0 resection had a near-significant impact on tumor control in radiation-naïve patients.

We further investigated this near-significant interaction.