“nominally significant”

Psychometric Architecture of Cognitive Constructs: Principal Components Analysis Twenty cognitive subtests with nominally significant ( P < .05) baseline group differences were selected for PCA.

In the KEGG pathway analysis 17 pathways were nominally significant but none passed the threshold of an FDR-corrected p-value < 0.05.

Of the remaining eight risk SNPs without significant signals, they found nine genes among four SNPs that were at least nominally significant ( P <0.05).

To detect excess significance bias, the Ioannidis test was used to examine whether the observed number of original studies with nominally significant ( p < 0.05) results (O) was larger than the expected number of original studies with nominally significant results (E) at α = 0.05.

However, several nominally significant ( P < .05) associations were identified.

Both nominally significant alterations ( p < 0.05) and those surviving multiple testing correction (FDR < 0.05) were reported; however, only FDR-significant findings were interpreted as robust.

In the mRNA-seq dataset, 6610 genes were nominally significant using p < 0.05, but only 40 genes remained significant after Benjamini–Hochberg FDR correction, including 31 upregulated and nine downregulated genes.

When phenotypic data from this cocaine trait was correlated with the same basal NAc gene expression data used to assess nicotine withdrawal‐related candidate genes in this study (Table 1B ), a total of nine genes were found to have a nominally significant cocaine phenotype correlation ( p ≤ 0.05, | ρ | ≥ 0.5), were located within the Nic_ptow1 SI, and had significant cis ‐eQTL ( Cbl , Dlat , Fxyd2 , Hyou1 , Ncam1 , Scn4b , Sorl1 , and Ube4a ).

Genes meeting a nominally significant threshold (p < 0.05 and fold change ±1.5) were input into The Database for Annotation, Visualization and Integrated Discovery (DAVID) v6.8 for pathway enrichment analysis ( Huang da et al., 2009a , Huang da et al., 2009b ).

As a post hoc analysis, when only patients were considered (and not controls), the same general pattern of results were observed as for the full group, with the relationship between higher polygene scores and lower test accuracy remaining significant at the P =10 −5 threshold, and nominally significant at the P =0.05 threshold.

For the remaining 12 SNPs, 10 showed the same allele effect direction as in the RS and 6 showed nominally significant association with height ( P < 0.05, Online Resource 2), highlighting GRM4/HMGA1 , GPR126 , CDK6 , HMGA2 , MYO9B , and UQCC1 genes.

Transcriptional differences between subject groups (i) Discovery Cohort ANOVA revealed 11 genes which showed nominally significant transcriptional differences (p≤0.05) between our three subject groups.

First, in step A, we screened for the presence of nominally significant ( P < 0.05) cumulative effects of associated methylation sites in whole blood, to determine which factors and variables to include in the full-scale analysis, thereby minimizing false positive findings in the downstream analysis.

Nominally significant associations (directionality and strength shown by beta estimates) are bolded (p < 0.05) and significant associations after correcting for testing 6 modules and 22 traits (FDR) are bolded and in red.

Supplementary Table S13 lists the nominally significant ( P < .05) or top 100 most correlated pathways.

A total of 22 SNPs showed nominally significant association ( p <0.05) with at least one lipid trait in at least one ethnic group, although not always with the same lipid traits reported as genome-wide significant in the original GWAS.

No significant group differences in BMI trajectories during the pandemic were observed (F(2,392) = 0.43; P = 0.65, η p 2 = 0.002); a nominally significant increase in BMI was observed in the participants at low risk for eating disorder (pre-PD < LD2, P < 0.05) but not in those with higher eating disorder risk ( Fig. 5(d) ).

In the BMTI, 42 metabolite-mRNA pairs (19 mRNA→metabolite; 23 metabolite→mRNA) showed a nominally significant (p-value < 0.05) causal effect.

We applied conditional analysis to all pairwise combinations of nominally significant ( P < 0.05) cell types within a given tissue to identify cell types whose trait association signals are independent of the other significant cell type 44 .

In eyes with serous PED at baseline, faricimab resulted in a greater decrease in maximum PED thickness throughout head-to-head dosing compared with aflibercept ( Fig 1 B), with nominally significant differences (nominal P < 0.05) at weeks 4 and 12.

Five SNPs showed nominally significant p-value (p-value<0.05), indicating that part of candidate SNPs of refractive error are associated with its two major intermediate traits.

Further, we found nominally significant ( p < 0.05) evidence of pleiotropy between TS risk variants and variants associated with lower ICV, accumbens, pallidum, and thalamus volumes and greater hippocampus volume (Table 1 ).

Although six correlations were nominally significant ( p < 0.05), including an inverse correlation between 7α,12α-dihydroxy-3-oxocholest-4-en-27-oic acid and prolactin (r = -0.212, p = 0.035), none remained significant after FDR adjustment.

For 2 variables (pre-BD FVC, lower in mild asthmatics from Canada; and PC20, trend for lower values in Romania), there were nominally significant interactions ( p < 0.05) between region and asthma severity cohort that did not pass multiple testing corrections with FDR < 0.05.

Variants that had both a directionally opposite, nominally significant association (p < 0.05) with log-BUN and a directionally concordant, nominally significant association with eGFR cysC were defined as validated loci.