Regions of interest One-sample Student’s t -tests was used to confirm that the EA ROIs showed nominally significant recruitment during Certain and Uncertain Threat anticipation ( P < .05, uncorrected).
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In the KEGG pathway analysis 17 pathways were nominally significant but none passed the threshold of an FDR-corrected p-value < 0.05.
To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).
Most relationships were attenuated when all components were added, with CHD, CHF, and CKD remaining nominally significant predictors ( p < 0.05).
To detect excess significance bias, the Ioannidis test was used to examine whether the observed number of original studies with nominally significant ( p < 0.05) results (O) was larger than the expected number of original studies with nominally significant results (E) at α = 0.05.
Separately, an excess significance test was conducted using the χ 2 test to investigate whether the observed number of studies with nominally significant results (O;”positive” studies, P < 0.05) differed from the expected number of significant results (E).
For the remaining 12 SNPs, 10 showed the same allele effect direction as in the RS and 6 showed nominally significant association with height ( P < 0.05, Online Resource 2), highlighting GRM4/HMGA1 , GPR126 , CDK6 , HMGA2 , MYO9B , and UQCC1 genes.
Genetic causal relationships across 21 digestive disorders Among 91 pairs of the 14 disorders with significant heritability, 64 pairs showed positive genetic correlation with Bonferroni correction (p ≤ 0.05/91), and the other 18 pairs had nominally significant genetic correlations (p ≤ 0.05), indicating considerable genetic basis of complex relationships among these disorders ( Figure 3 A; Table S5 ).
HMOX1 induction is nominally significant in HNSC (Wilcoxon p-value <0.05), and is not significant in UCEC or BLCA.
As a post hoc analysis, when only patients were considered (and not controls), the same general pattern of results were observed as for the full group, with the relationship between higher polygene scores and lower test accuracy remaining significant at the P =10 −5 threshold, and nominally significant at the P =0.05 threshold.
In the mRNA-seq dataset, 6610 genes were nominally significant using p < 0.05, but only 40 genes remained significant after Benjamini–Hochberg FDR correction, including 31 upregulated and nine downregulated genes.
Nominally significant ( p -value < 0.05) proteins in model 1 were validated in the KORA-Age1 study using the same model 1.
Nevertheless, in the Breslow–Day test, we detected that only two (rs72854462 and rs1438898 mapped to TEX41 gene) of the 821 tested SNPs were nominally significant ( p < 0.05), signaling heterogeneity in the odds ratios (OR) of these variants between Mexico and Colombia (see Supplementary Table 3 ).
In addition, the ovarian cancer patients had a nominally significant decrease in the number of 12 and 22 genotype carriers compared to the controls (p = 0.05) suggesting that the duplication may be protective for the disease with an odds ratio of 0.72 (95% CI, 0.53–0.99).
Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .
One of these haplotypes was nominally significant in the replication cohort ( P < 0.05) and was located in 6q21, a region which has been previously associated with bipolar disorder, a psychiatric disorder that is phenotypically and genetically correlated with MDD.
A score of + 1 was assigned if the protein showed positive and nominally significant ( p < 0.05) association with the disease, and +2 if the association was significant after multiple test correction ( FDR-adjusted p < 0.05).
Results were considered nominally significant at P < 0.05.
First, in step A, we screened for the presence of nominally significant ( P < 0.05) cumulative effects of associated methylation sites in whole blood, to determine which factors and variables to include in the full-scale analysis, thereby minimizing false positive findings in the downstream analysis.
Nominally significant associations (directionality and strength shown by beta estimates) are bolded (p < 0.05) and significant associations after correcting for testing 6 modules and 22 traits (FDR) are bolded and in red.
According to the regional plots ( Figures 5 E and 5F), we observed that the genetic variants at ABCA7 have nominally significant mQTL effects ( p < 0.05) on the methylation at loci of ABCA7 , NPY , BDNF , and NGFR at transcriptional regulatory regions ( Figures 5 E and 5F; Data S5 ).
The 295 nominally significant GO terms (raw p < 0.05) and the top 20 KEGG pathways were summarized in the Supplement ( Table S7 , S8 ).
We applied conditional analysis to all pairwise combinations of nominally significant ( P < 0.05) cell types within a given tissue to identify cell types whose trait association signals are independent of the other significant cell type 44 .
Results Allelic associations The European Caucasian sample set revealed nominally significant ( P <0.05) associations with gout at two block-3 SNPs: rs475688 and rs7932775 (SLC22A12; OR = 1.26, P = 0.043; OR = 1.32, P = 0.033, respectively) (Table 1 ).
Under conservative Bonferroni correction (α = 0.0033), the NLR–dyspnea ( p = 0.001) and MUST–appetite loss ( p = 0.001) associations remained statistically significant; the NLR–physical functioning, NLR–role functioning, and MUST–nausea/vomiting associations were nominally significant ( p < 0.05) but did not survive Bonferroni correction and are reported as exploratory.