“nominally significant”

Subsequently, we included all nominally significant determinants ( P < .05) as covariates in the multivariable models in each cohort independent of their effect estimates.

They first extracted nominally significant signals ( p <0.05) from three GWAS studies (WTCCC, German, and NIMH GAIN datasets; Fangerau et al., 2004 ; Wellcome Trust Case Control Consortium, 2007 ; Baum et al., 2008 ), and prioritized potential candidates based on independent, converging lines of evidence from various bioinformatics resources.

Although no individual lipid species remained significant after Benjamini–Hochberg false discovery rate correction, the lipid alterations showed systematic class-level trend which was significant for several lipid classes under Fisher’s combined probability test (as seen in Figure 1 ), and therefore, species-level results are still reported as nominally significant (unadjusted p < 0.05).

According to the regional plots ( Figures 5 E and 5F), we observed that the genetic variants at ABCA7 have nominally significant mQTL effects ( p < 0.05) on the methylation at loci of ABCA7 , NPY , BDNF , and NGFR at transcriptional regulatory regions ( Figures 5 E and 5F; Data S5 ).

Although no striatal gene expression changes reached significance following FDR correction (FDR <0.1) in HTT-ASO-treated YAC128 mice at the 6-month time point, we identified 105 downregulated and 148 upregulated genes that were nominally significant ( p < 0.05) in response to treatment ( Table S2 ).

The only nominally significant ( p < 0.05) difference among the randomization groups was for height, which was highest in the metformin group.

Correlations were considered nominally significant at P < 0.05 and significant after correction if q < 0.05.

For nominally significant sites ( p < .05), findings were considered meaningful and thus described here if at least one of the following two a priori criteria were met: previous association of the CpG with traumatic stress or brain and behavioral functioning, or situated at known or putative TFBs [ 57 ] (indicated in Table 1 ).

Interestingly, SCZ showed a nominally significant proportion of caQTL-mediated heritability in LCLs (p<0.05, MESC), consistent with the hypothesis that B cells may play some role in SCZ pathogenesis ( Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014 ; van Mierlo et al., 2019 ).

As most results were nominally significant (P < 0.05) but did not meet the stringent corrected threshold (P < 0.005), they are cautiously interpreted as indicating potential trends in the discussion of our findings.

As this was an investigative study, nominally significant statistics ( p value < 0.05) were reported.

Using a 25% cumulative variance threshold, 38 of the 55 gene sets enriched at FDR < 0.05 under the 50% threshold remained nominally significant ( p value < 0.05), indicating that the primary biological signals were largely preserved.

Most of the association information derives from the main effect test, but the intervention interaction tests have rather different P -values across these SNPs, with rs7705343 having nominally significant ( P < 0.05) interactions with each of E-alone, DMQ, and CaD, while interactions in relation to rs4415084 are not significant for any of the interventions.

Results were nominally significant at two-sided p<0.05.

For 43 of the 49 traits, we estimated a nominally significant ( P <0.05) proportion of variance explained by all SNPs on the Affymetrix 5.0 genotyping array ( ).

Although no locus showed Bonferroni-significant convergence between both VHD and gastrointestinal disorders, five genes ( CFDP1 , STAT3 , IMPDH2 , UBE2L3 , and STMN3 ) presenting Bonferroni-significant association with at least one of the gastrointestinal disorders tested (Supplementary Table 6A ) also had a nominally significant effect on VHD (SMR P < 0.05, HEIDI P > 0.05; Supplementary Table 6B ).

Within KEGG, the acRPB1 enriched genes had nominally significant overlap (uncorrected p < 0.05) with genes involved in several developmental signaling pathways, focal adhesion, and actin cytoskeleton regulation (Additional file 5 ).

Variants that had both a directionally opposite, nominally significant association (p < 0.05) with log-BUN and a directionally concordant, nominally significant association with eGFR cysC were defined as validated loci.

At a nominally significant level ( p -value < 0.05), there were 7750 (29.20%) heritable probes from 6603 unique genes.

This showed that 16 of the 28 gene groups showed evidence of similarity; 12 for growth, 10 for HPO (6 overlap with growth) significant at p < 0.05 after Benjamini Hochberg correction, and 1 for development nominally significant at p < 0.05 (overlaps growth and HPO).

A score of + 1 was assigned if the protein showed positive and nominally significant ( p < 0.05) association with the disease, and +2 if the association was significant after multiple test correction ( FDR-adjusted p < 0.05).

HFC was significantly negatively associated with D ISF in the left thalamus ( β = −0.660, FDR-adjusted p < 0.001), with nominally significant associations in the right parahippocampal gyrus and right thalamus (FDR-adjusted p > 0.05).

Genes were selected for correlation and PCA analysis if they displayed nominally significant changes in the QuantiGene Plex assay (p ≤ 0.05) as well as nominally-significant changes in either human lymphoblasts exposed to ethanol, mouse NS-5 cells exposed to ethanol, or PBLs from binge-drinking adolescent rats.

We declare h g 2 >0 to be nominally significant (P<0.05) if h g 2 is larger than each value analogously estimated from 19 data sets with sample labels randomly permuted (thus, 5% of genes will be nominally significant even in the absence of a true effect).

The sentinel variant rs62040020, which resided within an intron of Jupiter microtubule associated homolog 2 ( JPT2 ) on chromosome 16 (effect allele frequency (EAF)=10.6%), was measured in all six studies with a high imputation quality (r 2 >0.88 across all six studies) and was nominally significant (p<0.05) in four of the six studies ( supplementary table 2 and figure 4 ).