Barely Significant
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“showed a trend”

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CD163 + Regulatory Myeloid Cells Disperse from CD8 T Cells and Lose Arginase1 at the Interface Iba1 + CD163 + regulatory myeloid cells (15,979 cells; 84.2% CX3CR1 + ) showed a trend toward reduced spatial enrichment with CD8 T cells in MG- Igf1 KO tissue (CN median z = 18.0, MG- Igf1 KO median z = 13.7; p _adj = 0.240; Figure 8 A), consistent in direction across five of six MG- Igf1 KO mice.
However, when HIF-1α was inhibited, claudin 2 and claudin 3 protein expression showed a trend for downregulation, whereas their mRNA expression levels were highly significantly downregulated, indicating that claudin 2 and claudin 3 expression was regulated by the level of the intranuclear transcriptional activity of HIF-1α.
GPs practicing in towns with fewer than 5,000 inhabitants were significantly more likely to adopt SP compared to the reference group (OR = 3.024, CI 1.13–8.13, p = .028), while male GPs showed a trend toward higher adoption, though not reaching statistical significance (OR = 2.114, CI 0.88–5.06, p = .09) (see Supplementary Tables 2, 3 ). 4 Discussion This study demonstrates that while most participants are unfamiliar with the term SP, some are already performing SP-like activities, and there is a strong willingness to implement SP formally.
Among the cortical atrophy scores, temporal cortical atrophy showed a trend towards more severe grades in patients with neurological dysfunction, approaching conventional significance, while global cortical atrophy showed a weaker, non-significant trend in the same direction.