Further Cox regression analyses, performed using the TCGA dataset, revealed a significant association between the gene signature and patient outcomes: four out of the five genes were independently associated with survival ( p < 0.05; hazard ratios ranging from 1.48 to 1.54), while MS4A6A showed a trend toward significance ( p = 0.055, HR = 1.4).
Postoperative contrast-enhancing tumor volumetry showed a trend towards longer survival for smaller postoperative volumes ( p = 0.0551).
In multivariate analysis, other TP53 mutations only showed a trend of decreased PFS ( p = 0.056); however, codon 273 mutation remained a significant prognostic factor for oligodendroglioma OS in multivariate analysis (HR (95% CI): 9.05 (2.39–34.31), p = 0.001).
100.0%; p < 0.0001), whereas the DFS difference in patients presented GI bleeding was almost significant (76.3% vs. 95.6%; p = 0.0560) ( Figure 9 , Figure 10 , Figure 11 and Figure 12 ).
There was a borderline significant difference ( p = 0.056) in the mean age at diagnosis between the wild-type A/A genotype (54 years old) and the variant G/G genotype (61 years old) or the heterozygous A/G genotype (61 years old).
A favorable trend for better response was found for a higher IMRT-SIB dose ≥ 55 Gy (OR 0.57; 0.32–1.01, p = 0.056).
Step 1 of the model that regressed personal control on supportive care use, holding problem-focused coping consistent across patients (the c ’ path), approached significance ( b = 0.06, se = 0.03, p = 0.056), suggesting that cancer patients scoring higher for personal control were more likely to use survivorship support programmes (see Figure 1 ).
Almost all the cancer cell MMP9 positive cases expressed IL-8 (18/19) on IHC, and the correlation was close to being statistically significant ( p = 0.056).
Endocrine Therapy and TSR High TSR predicted poor outcome in luminal cancers treated with endocrine therapy in OS ( p = 0.030) and was close to significance for BCSS ( p = 0.056).
However a benefit of aRT over esRT on these long-term outcomes might exist, especially given the statistical benefit of aRT on 15-year metastasis-free survival ( p = 0.036) and the trend toward significance regarding overall survival ( p = 0.056) [ 6 ]. aRT also significantly reduces the need for subsequent androgen deprivation therapy, which is known for its inherent toxicity [ 36 ].
Regarding the direct effect of engagement on arousal, it is only marginally significant ( β = −0.16, 95% CI [−1.11, 0.01], p = 0.056).
Notably, the ICG cohort demonstrated a trend toward significance compared to the MB group, although it was not reached ( p = 0.056) ( Table 3 ).
As for F3 , the difference was only marginally significant (paired t -test, p = 0.056; Figure 3 a).
However, data are less compelling for APL patients carrying the FLT3 -D835 mutation: RR values included values smaller than 1, and the p -value was only marginally significant ( p = 0.056).
In the MMRd subgroup, LVSI showed a strong trend toward increased recurrence risk (OR 5.17, 95% CI 0.96–27.91, p = 0.056).
wild-type BCOR : 18.4 months (95%-CI: 16.7–21.4), HR of LOF compared to wt BCOR = 1.409 (95%-CI: 1.010–1.965), p = 0.044), and a strong trend for reduced median OS in a multivariable analysis (HR = 1.495 (95%-CI: 0.990–2.258), p = 0.056, Figure 4 C).
In limited dilution assay with stem cell-enriched NSC-grown SMA-560 cells, temozolomide showed a trend ( p = 0.056) towards radio-sensitization of the cells at high irradiation doses ( Figure 5 D).
Whether or not conization was performed before radical surgery had marginal significance for both PFS (HR 0.65, 95% confidence interval [CI] 0.41–1.01, p = 0.056) and OS (HR 0.59, 95% CI 0.34–1.02, p = 0.059).
A statistical trend was shown for shorter OS in sarcopenic patients (12.1 vs. 20.0 months; p = 0.056) ( Table 4 and Figure 4 ).
Margin status was near statistical significance on univariate analysis ( p = 0.056) only when considered as a gross margin, as it is typically used in nomogram prediction and was included in the multivariate analysis.
Kaplan–Meier survival analysis demonstrated that low RAD50 expression in the tumor center (TC) was significantly associated with worse DFS ( p = 0.016; Figure 1 A), whereas the association of RAD50 expression and OS was of borderline significance ( p = 0.056; Figure 1 B).
The difference in the probability of EFS was almost significant between SRG and HRG (0.56 ± 0.04 vs. 0.47 ± 0.03; p = 0.0567).
CD31 exhibited a borderline inverse association (adjusted OR = 0.89, 95% CI: 0.78–1.01, p = 0.063), while fibronectin retained a marginally significant inverse relationship (adjusted OR = 0.98, 95% CI: 0.96–1.00, p = 0.057).
In the multivariate model, HER2 status (HR = 0.630, p = 0.008), menopausal status (HR = 2.362, p < 0.001), the presence of BRCA1/2 mutations (HR = 3.300, p = 0.01), axillary surgery (HR = 2.091, p = 0.003), adjuvant chemotherapy and radiation therapy (HR = 0.373, p < 0.001 and HR = 2.534, p < 0.001), higher pT and pN stages, and Ki-67 expression exceeding 20% (borderline significance, p = 0.057) remained as significant predictors of OS.
Consistently, there was a borderline significant association between % change in SSR-TV and % 53BP1 + cells at baseline ( r = 0.4215, p = 0.0570) and % change in 53BP1 + cells between BL and +24 h ( r = −0.3866, p = 0.0834) in correlation analysis.