Multivariate Cox proportional hazards regression analysis adjusting for PS, pTNM stage, tumour size and nodular involvement revealed that lower PHD1 mRNA expression in the primary tumour had borderline significance for shorter OS (HR = 0.908; 95% CI: 0.822–1.004; p = 0.06) ( Table 4 ). 4.
10 min) showed a marginal trend for CVAEs ( p = 0.06) [ 23 ].
A trend toward significance was observed for four-year PFS (71%, 58%, and 42% for AA, AG, and GG genotypes, respectively; p = 0.06), while four-year OS differed significantly across the three subgroups (78%, 61%, and 45%, respectively; p = 0.04).
Detection of FRE colonization on pre-transplant testing predicted for subsequent re-hospitalization ( p = 0.002); the detection of FRE colonization, including the post-transplant samples, was of borderline significance ( p = 0.06).
However, LDH levels showed a trend toward increased risk of transformation (hazard ratio [HR] 2.6; 95% confidence interval [CI], 0.95–7.6; p = 0.06).
There was no significant variable to predict major revision, although the administration of perioperative chemotherapy was a marginally significant variable ( p = 0.06).
Patients with delayed surgery (C3) showed a non-significant trend toward increased risk (HR 5.05; 95% CI 0.53–48.6; p = 0.161), and those who did not undergo indicated surgery (C4) demonstrated borderline significance (HR 7.27; 95% CI 0.92–57.5; p = 0.060).
CRT significantly reduced local progression rates (32% versus 46%, p = 0.030) and showed a trend towards better median PFS (9.9 versus 8.4 months, p = 0.060) and longer median time without retreatment (6.1 versus 3.7 months, p = 0.020).
Intriguingly, Binet stage C patients tended to have a higher level of RelB activity compared to stage A patients ( Figure 6 F), but this did not quite reach significance ( p = 0.06), likely due to three Binet stage A cases that had high RelB activity (including one with ATM loss).
We observed a statistically significant genotype-by-sex interaction for MDM4 rs4245739 ( p = 0.01) and a borderline significant interaction for rs1563828 ( p = 0.06).
Stage IV disease demonstrated a borderline significant association with worse disease-free survival, with a HR of 2.81 (95% CI 0.96–8.27, p = 0.06) compared to stages I-III.
The recurrence rate observed by response type approached significance ( p = 0.06) ( Table 2 ).
Although only approaching significance, DGE and PPH presented a higher frequency in the PPAP population than in the no-PPAP group ( p = 0.06 and 0.08, respectively).
A positive trend near statistical significance was also found for a lower N/L ratio ( p = 0.06).
ATRX gene conservation showed a favorable trend in terms of OS despite a significant result was not reached ( p = 0.06; median OS of 11 months vs. 29 months, respectively for ATRX positive vs. negative; HR 2.69, 95% CI 0.92–7.83).
After 4 weeks, X-rays and μCT analyses showed a trend of reduction in osteolytic lesion incidence (chi-square test; p = 0.06) ( Figure 2 b and Supplementary Figure S2a ) along with a reduced osteolytic area ( Figure 2 c,d) in the tibias of N-Cadherin High compared to N-Cadherin Low cell-injected mice.
There was an observed trend towards longer operative time for the MIS-ILND approach (mean difference 28 min; 95% CI −2 to 58 min, p = 0.06), particularly with the robotic-assisted technique.
SMI and GS also increased, but were only borderline significant ( p = 0.06).
The study observed a marginally non-significant increase of HPV prevalence among OPC cases diagnosed after 2010 (45 vs. 28.3%, p = 0.06) [ 6 ].
In univariable analyses, germline variation in GZMB and PDCD1 showed a trend towards associations with OS according to the dominant model (HR 1.811, 95%CI 0.945–3.364, p = 0.060 and HR 2.027, 95%CI 0.998–4.118, p = 0.051, respectively).
Although not statistically significant, patients with recurrent disease showed a trend toward longer OS and PFS than those with unresectable disease (OS, p = 0.06; PFS, p = 0.05) ( Figure 2 ).
Patients holding an SUV max above this value exhibited a statistical trend toward a longer median PFS (52.0 versus 18.7 months; p = 0.06), Figure 4 .
Furthermore, genetic ancestry, specifically African American ancestry, was also significantly associated with CIPN change from baseline (CE = −7.63, SE = 2.43, and p < 0.002) with an overall significance of p = 0.007, while sex was only borderline significant (CE = 3.29, SE = 1.77, and p = 0.06), Table 2 .
ER+ cancers demonstrated a strong trend towards fewer total CD8 + T cells as compared to ER− disease ( p = 0.06; Figure 4 a).
In our study, pCR was an independent prognostic factor of longer DFS and almost significant for OS ( p = 0.06).