Excerpts

We also reanalyzed our microarray data searching for genes of the Ub/Ub-like pathways close to significance in a context of oxidative stress (0.05 ≤ p < 0.06).

Interestingly, in case of tumor recurrence, patients that received adjuvant GEMOX showed a trend towards worse median post-relapse OS when compared to those without adjuvant therapy (8.0 vs. 15.2 months; HR 1.55 (95% CI 0.98–2.47); p = 0.06).

However, when similar analysis was done on BCER− patients, a marked trend ( p = 0.06) was found, especially evident during the first 200 days after diagnosis, suggesting that high OBR expression is associated with lower survival ( Figure 1 C).

p ≤ 0.05) and GII (borderline significance of adj. p = 0.06; Table S11 ).

The trypsin-like domain showed a statistical trend towards reduced proteasome activity in ICM tissue (0.78 ± 0.11 μU/mg), compared to DCM (1.06 ± 0.08 μU/mg) and control (1.00 ± 0.06 μU/mg, p = 0.06) tissue ( Figure 1 B). 2.2.

Regarding Clec7a expression, exposures of 10 μM metformin or 10 μM empagliflozin also showed a trend towards increased Clec7a expression ( Figure 6 D) at 24-h (2.33-fold, p = 0.06; 2.23-fold, p = 0.08), respectively.

TUNEL showed a trend for increase in the responders ( Figure 2 B, p = 0.060). 2.3.

T cells exposed to IL-7/15 and co-cultured with B16 cells approached significance compared to IL-2 exposed T cells cultured with B16 cells ( p = 0.06), a finding we had demonstrated previously [ 6 ].

A strong trend towards an absolute decrease in LVM was observed in the treatment group ( p = 0.06) [ 51 ].

For let-7e, association with amputation approached but did not reach significance ( p = 0.060). 2.3.

Alterations in ATM were more frequent among H/L patients (17.3%) compared with NHW patients (7.9%), a difference approaching borderline significance ( p = 0.06).

Importantly, the KA+MI 120 mg group displayed similar learning dynamics: in addition to a significant difference in mean escape latency between day 1 and 4, there was a significant reduction in the latency period on day 4 relative to day 2 ( p = 0.03) and a nearly significant reduction on day 3 relative to day 1 ( p = 0.06).

Dunnett’s post hoc testing after ANOVA revealed a significant preventive effect for ectoine and a clear trend for NADA ( p = 0.06). 5-Hydroxyectoine had considerably smaller effects that did not prove to be statistically significant, probably due to the sample size of n = 10. 3.

Although NOP receptor expression in tissue from ModTBI rats appeared lower than in sham rats, it did not quite reach significance with Dunn’s multiple comparisons test ( p = 0.0602) 24 h post-TBI ( Figure 3 a).

The results (see Figure 6 ) outlined that the dogfish that were acclimated to 75% seawater (SW) showed somewhat higher average levels of mRNA expression than fish acclimated to either SW (100%) or 120% SW, although this higher level was not quite statistically significant ( p = 0.0606 and 0.0805, respectively). 2.3.

Although borderline for statistical significance, IL-10 showed a trend for inverse correlation with C3 and C4 levels (r = −0.359, p = 0.0608 and r = −0.326, p = 0.0906, respectively).

When miR-29c-3p was inhibited, Npc1 expression was up-regulated compared with the AAV-scrambled/saline group (* p < 0.05), meanwhile Npc1 expression in the AAV-anti-miR-29c/METH group showed a trend of up-regulation compared with the AAV-anti-miR-29c/saline group (* p = 0.061, Figure 6 C).

However, in the RT-only subgroup, this association was only borderline significant ( p = 0.061). 2.5.

Effect of GPR37L1KO on the Corticosterone Level after PAT A three-way ANOVA on the level of circulating corticosterone revealed a significant effect of genotype x sex [F (1,54) = 4.04, p = 0.049; Figure 6 ] and a strong trend towards significant effect of genotype [F (1,54) = 3.66, p = 0.061; Figure 6 ], age x sex [F (1,54) = 3.65, p = 0.061; Figure 6 ] with no significant effect observed for other factors ( Figure 6 ).

Moreover, when analysing the total counts during the first 60 min of the test ( Figure 5 B), univariate ANOVA showed an almost significant effect of drug treatment (F(3,44) = 2.643, p = 0.061).

Pre-Conditioning Serum Leptin Levels Predict Time to Relapse (TTR) Depending on Disease Entity and Disease Stage In the discovery cohort, multivariate Cox regression analysis showed a trend towards lower relapse rates with higher serum Leptin levels (HR per log2 increase (95% CI): 0.91 (0.82–1.00); p = 0.061; Table S1 ).

In this regard, GSPE showed a trend to increase mRNA levels of Sirtuin 1 ( Sirt1 ) compared to CAF-VH group in animals subjected to standard photoperiod (L12) ( p = 0.061).

Total band density for eNOS (using the non-phospho-discriminating antibody) showed an increase in the IHS group in outer medulla, with a strong trend ( p = 0.061) for cortex.

Due to the absence of a significant group-by-time interaction (noting a statistical trend for WBCs, p = 0.061), temporal dynamics were assessed based on the pooled data from both groups.

Second, we did not observe significantly higher SIA/anti-CCP ratios in patients with DAS28-ESR remission (<2.6) compared to non-remission patients (≥2.6), which was previously reported with borderline significance ( p = 0.061) [ 13 ].