Excerpts

Intronic rs12505266 of CLOCK was significantly associated with an increased predisposition to breast cancer among recessive homozygous genotypes OR = 1.22 (0.83–1.79), p = 0.057 and at marginal significance under a recessive genetic model OR = 1.38 (0.97–1.96), p = 0.07.

EAE-mice treated with “in/out” enriched-aCSF exchange therapy at days 6–8 following EAE-induction showed a trend towards a lower average clinical EAE-score at days 9–11 post EAE-induction (repeated ANOVA (f(1,16) = 3.73, p = 0.07), with a t -test for day 10 (4 days after starting treatment/2 days following end of treatment) revealing a significant difference in the average clinical score between treated and untreated mice (0 vs. 1.08 ± 0.30, respectively, p = 0.012).

Under RT conditions, the AIP mice showed a trend of reduced glucose uptake rate compared to the WT mice ( p = 0.07; Figure 4 B,C), reaching statistical significance in those receiving the B. coagulans -supplemented diet, probably because they dissipated less energy under fasting and room-temperature conditions.

FACS analysis showed that in LPS-injected mice treated with 1-PPA, only the activated CD8/totalCD8 ratio was significantly lower than in LPS-injected mice ( p = 0.048) ( Figure 6 D3), while the activated CD4/totalCD4 ratio showed a trend to be lower in untreated LPS-injected mice ( p = 0.07) ( Figure 6 D2).

The presence of DDR gene alterations, most commonly identified in ERCC2 , showed a trend for better bladder or metastatic recurrence-free survival (HR 0.47, p = 0.070); this finding is in line with studies on neoadjuvant chemotherapy for MIBC [ 48 , 49 ] and systemic chemotherapy for advanced urothelial carcinoma [ 50 ], showing significantly better clinical outcomes for tumors with DDR gene alterations.

The H3K9me3 staining for IMR90 appeared also to be increasing, but the slope was not quite statistically significant ( p = 0.07).

Only in the univariate analysis, GSTM1 -null patients showed a trend towards an increased incidence of SOS (26% vs. 15%, p = 0.07), diagnosed according to the modified Seattle criteria [ 51 ].

Age showed a weak trend toward influencing Tc levels ( p = 0.07), with older patients slightly more likely to have higher concentrations. eGFR, an essential marker of kidney function, was not significantly associated with Tc levels in this model ( p = 0.11), suggesting that other factors, such as genetic variations, may play a more direct role in influencing drug concentration.

STZ administration showed a trend toward reduced mature BDNF content compared with the SHAM group ( p = 0.07), whereas combined VitD 3 and DMF treatment significantly increased mature BDNF content compared with the STZ group.

4/12 in stage I + II; p = 0.007) and showed a strong trend toward higher ISUP grade (3 + 4:21/28 vs. 5/12 in 1 + 2; p = 0.070).

Significant differences were observed between G2 and G3 ( p = 0.005), and a trend towards significance was noted between G4 and G3 ( p = 0.07) ( Table 2 ). 2.3.

Gasdermin D revealed only a marginal trend to predict POD (OR 1.50 [0.97–2.32], p = 0.07), which faded when adjusted for covariates in models 2 and 3.

Although circulating blood monocyte count above the median in our study was associated with peripheral atherosclerosis of only borderline significance (OR 1.8; 95% CI 0.9–3.3, p = 0.07), the combination of this parameter with higher Lp(a) levels ( ≥ 30 mg/dL) was observed almost three times more frequently in patients with peripheral atherosclerosis than in patients without atherosclerosis (27% vs. 10%, p < 0.01), indicating synergism between inflammatory and lipid factors.

In line with these findings, we observed a strong trend ( p = 0.070) toward increased N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels, which were more than doubled in patients with a higher MARK4 expression ( Table 1 ).

For Factor 1, borderline significant differences were observed between the groups ( p = 0.07). with the highest levels noted in CD patients.

The study showed a marginally significant increase of plasma triglycerides, by 0.03 mmol/L per 10 nmol/L increase in serum 25OHD ( p = 0.07).

The main effect of CDNF injection on the phospho-c-Fos/c-Fos ratio was only marginally significant (F 3,21 = 2.66, p = 0.07) according to a one-way ANOVA.

Notably, CA2 expression was not significantly altered in postmortem brain samples from SCZ or BD patients, and antipsychotic drug use showed an inverse trend with CA2 expression in SCZ (r = −0.59, p = 0.07) and a positive trend in BD (r = 0.60, p = 0.07).

Cin30 administration showed a trend toward reversing the Lac1-induced effect ( p = 0.07; Figure 5 B).

The same was true for hiPSC line CaSR, except for the fact that Perimeter only showed a trend towards statistical significance ( p = 0.07).

Notably, serum cholesterol levels showed a trend of decreasing in response to losartan ( p = 0.07) and mirabegron ( p = 0.08) compared to the DOXO-only group ( Table 2 ).

Although the impact of 10 μg/mL KP1019 on lag was blocked at pH 6, multiple linear regression analysis revealed that the overall impact of pH on lag only approached significance ( p = 0.07).

Moreover, histomorphometry showed a decreasing trend ( p = 0.07) of the osteoclast number in Lcn2Ab-treated mice ( Figure 5 I,J), while osteoclast surface was significantly reduced ( Figure 5 K).

Two-way ANOVA also showed a close-to-significant effect of two compounds: 8-OH-DPAT ( F (1,2) = 3.89, p = 0.07) and 25CN-NBOH ( F (1,2) = 3.66, p = 0.07).

In the subgroup of patients with elevated BMI, the mean glucose value at 120 min showed an increasing trend ( p = 0.07); in patients with normal BMI (<25 kg/m 2 ), the mean glucose value at 120 min was 5.64 ± 1.2 mmol/L, and in patients with elevated BMI (≥25 kg/m 2 ) the value was 6.54 ± 1.66 mmol/L.