Excerpts

Memory condition (AM+/AM−) remained a highly significant predictor in both a Gaussian linear mixed model (estimate = 0.473, t = 4.793, p < 0.01) and a Poisson generalised linear mixed model (estimate = 0.195, t = 6.651, p < 0.01).

This compilation reveals a significant trend towards lower skeletal δ 13 C as depth increases (−1.4‰ per 5 m of depth; R = 0.68, p < 0.01).

A 1.5-fold change expression cut-off for ratio experiments was applied together with anti-correlation of dye-swapped ratio profiles, rendering the microarray analysis highly significant ( P < 0.01), robust, and reproducible 48 .

Under the deforestation since the 1970s, Amazon (15°S–0°, 40°W–80°W) surface air temperature has exhibited an increasing trend (0.26 °C per decade, p < 0.01), while precipitation has shown a decreasing trend (−0.15 mm day −1 per decade, p < 0.01, Fig. 1b , Supplementary Fig. 1 ).

In addition, for FI, the analyses showed multiple significant enrichment peaks in blood in men, whereas those in women were only nominally significant ( P = 0.01) (Supplementary Fig. 3a ).

There is a significant trend towards longer-duration warm events (slope = 7 d decade −1 , r 2 = 0.3, p = 0.01), with the mean duration increasing from 8 d during the 1980s to 26 d during the 2010s, but there is no significant change in the duration of cool events (mean value = 12 d, p = 0.18).

S1e ) together with a strong trend toward reduced vS1 selectivity during the stimulus period ( P < 0.01, n = 21 and 31 sessions for control and APP-KI mice, respectively, one-tailed bootstrap without a multiple-comparison correction method, Fig. 1e ).

It is evident that the STRF differences faded within 0.8 s of the target interval, though remaining marginally significant (paired t -test: P <0.010, n =151); they completely disappeared during the second passive session (paired t -test: P <0.520, n =151).

The nominally significant association signal at this lead variant (rs11934731, effect size for the minor allele = 0.029 SD, P -value = 0.01, MAF = 33%) was slightly attenuated when we performed conditional analysis with MEPE p.Lys70IlefsTer26 as a covariate in the model (effect size conditional = 0.021 SD, P -value conditional = 0.06; Supplementary Fig. 1 , Supplementary Data 1 ).

89 ZED88082A in tumor lesions from pre-CART to post-CART Among the 21 evaluable patients, 89 ZED88082A tumor uptake first declined from a geometric mean SUV peak of 4.0 (95%CI [3.3–4.8]) pre-CART to 2.4 (95%CI [1.8–3.3]) post-CART day +5, whereafter an increasing trend to 3.6 (95%CI [2.8–4.7]) post-CART day +7 was observed ( P < 0.01; Fig. 4a , Supplementary Fig. 6a ).

Direct comparison of VIP ChR2::EYFP and VPAC2 ChR2::EYFP PRCs therefore revealed highly significant time effects and interaction between time and cell-type (both p < 0.01) (Fig. 5f ).

Deletions (including frameshift deletions; hGIS1, P =0.0004; hGIS2, P =0.0038), mononucleotide repeat frameshifts (hGIS1, P <0.0001; hGIS2, P <0.0001) and splice-site mutations (hGIS1, P =0.0003; hGIS2, P =0.0002) were present at significantly increased levels in both hGIS1 and hGIS2 genes, and nonsense mutations were present at statistically significant increased levels in hGIS1 and at borderline significant levels in hGIS2 (hGIS1, P =0.01; hGIS2, P =0.0613) ( Supplementary Data 3 ).

The occurrence area of the subsurface-reversed MHWs showed a rising trend of 1.27 × 10 14 m 2 yr −1 over 2001–2020, followed by the deep MHW, with an increasing trend of 7.38 × 10 13 m 2 yr −1 ( p < 0.01; Fig. 6a ).

The total population size of a country had a highly significant effect ( p < 0.01) on species introductions, and a significant effect ( p < 0.05) on species establishment (Fig. 5F ).

Including the TD group in the analysis (i.e., analyzing all children together) resulted in a similar result, except that the RRB scale now showed a trend in the same direction (ADI-R total n = 175, r = 0.193, P = 0.010; ADOS CS n = 179, r = 0.216, P = 0.004; ADOS SA CS n = 179, r = 0.230, P = 0.002; ADOS RRB n = 179, r = 0.140, P = 0.062; Supplementary Fig. 3 ).

During the summer nighttime, the warming effect shows an increasing trend of 0.040 K/decade ( p = 0.01), but the magnitude is only about one-fifth of the daytime ΔLST s negative trend (−0.188 K/decade, p = 0.01) (Fig. 1c ).

While standard differential expression analysis comparing control and treated rats identified 0 genes with adjusted p value < 0.05, a targeted approach focusing on the members of the CP/CPPS-proximal interaction network identified 5 genes with a nominally significant p value < 0.01.

We propose that nutrient availability from weathering processes enhance peat decay in the youngest minerogenic mires studied, resulting in a decreasing trend in lawn decay rates (based on Clymo’s 29 model) with increasing mire age (Fig. 4a , R 2 = 0.9, p = 0.01).

In particular, for each of the genomic region windows 100 kb upstream of the gene, 100 kb downstream of the gene, and within the gene body, we observed highly significant overlap between CGI probes with SV-methylation association ( p < 0.01 by linear model with covariates) and CGI probes for genes with germline SV breakpoint patterns positively associated with pediatric brain tumor patient survival (one-sided Cox p < 0.05, correcting for tumor histologic type, Fig. 6a ).

The number of nominally significant features expected at a given p -value cutoff (e.g., p < 0.01) due to chance alone, as predicted by probability theory ([total number of features] X [nominal p-value cutoff]), was similarly found when shuffling the 1 Mb germline SV breakpoint and methylation datasets and carrying out the same analyses.

While cytokine pathway signal differs by treatment, all tested prioritized candidates—except RGS14 —show nominally significant ( t test, P < 0.01) signal in at least one treatment condition (Supplementary Fig. 9b ).

5 , neither scenario substantively changes our conclusions, with the only changes in significance being for percent Latino/a and percent without a high school diploma—both of which were only marginally significant in our primary models ( p > 0.01).

In the three CRC groups, the levels of these five urinary proteins showed a gradient with an increasing trend that correlated with disease progression, achieving the highest levels in DM ( P < 0.01 for all; Fig. 4a ).

Data were analysed using the Mann–Whitney U test, in which differences were considered significant (*) at P values of ≤ 0.05 and highly significant (**) at P values of ≤ 0.01.

There was a highly significant difference in cell markers among the MOL1 and MOL2 groups (all p < 0.01; Fig. 2a, b ; Supplementary Fig. 9a, b ).