We then validated our findings using western-blotting for AATC, which showed a trend for decreased levels in SNCA 3x already at a basal level ( p = 0.2775), with a higher tendency noted upon the addition of TNF ( p = 0.1870) (Fig. 5H ), in line with the proteomics finding.
In the case of IL-5 and IL-10, 15% (11/73) and 16.4% (12/73) of patients diagnosed <10 years ago responded, respectively, while only 4.3% (1/23) of those diagnosed >10 years ago responded, which corresponded to a nonsignificant trend ( p = 0.283 and 0.179) in the same direction as observed for IFNγ.
Instead, we observed a weak trend towards prolonged survival in the KRAS-driven intestinal cancer model (median survival of 502 days ( VKras G12D/+ ;Snail KI/+ ) vs 354 days ( VKras G12D/+ ); p = 0.29; Fig. 2h, i ).
Additionally, tracer uptake in the blood pool of symptomatic EAE mice was significantly higher than in naïve mice (p < 0.0001), with a trend toward significance in pre-EAE mice (p = 0.29; Supplementary Fig. 3a ).
The percentage of potential T-cell responses achieved in each category revealed a nonsignificant trend toward higher responses among ACPA + RA patients to the created peptides (33%) than to no change (17%; P = 0.2918) and destroyed (13%; P = 0.1692) peptide groups, in addition to significantly more frequent responses among ACPA + RA patients to the created peptides (33%) than observed for the controls by χ 2 test (2.5%; P = 0.0002; Fig. 6b ).
Although the increase of oral Veillonella showed a trend toward higher esophageal colonization, this was not statistically significant (Fisher’s exact test, p = 0.303, n = 10; Supplementary Fig. 4L ).
While CosMx had significant differences between percentage of cells based on biological cell size differences ( p = 0.023), Xenium-UM and Xenium-MM also showed a trend towards a higher percentage of cells with gene pairs of bigger biological differences ( p = 0.31).
Macrophages/monocytes showed a decreasing trend without statistical significance ( p = 0.3254) (Fig. 1e ).
Yet, in BMDMs that engulfed ACs, Wdfy3 knockout BMDMs showed a trend of higher F-actin signals (Fig. 2g , right panel, P = 0.34).
Indeed, postextinction l -DOPA administration significantly increased the number of potential CS+ offset-related vmPFC pattern reactivations (time × group: F 3,114 = 3.51, P = 0.02, partial η 2 = 0.09; n = 40), particularly 45 min after extinction and there was still a near-significant trend 90 min after extinction (post hoc two-sample t test; pre: P = 0.39; post: 10 min: P = 0.09; 45 min: T 38 = −3.05, P = 0.004, Cohen’s d = 0.97; 90 min: T 38 = −1.95, P = 0.06, Cohen’s d = 0.62; n = 40; Fig. 2e ).
This relationship was only marginally significant in monkey S (ANOVA; monkey N: 1.03, p = 0.46; monkey S: F = 1.73, p = 0.04).
While a positive trend was seen ( rightmost column, Fig. 5b , blue ), this was not significant (Pearson correlation p = 0.47, N = 33).
2c ) .When we excluded the good prognosis subgroup (Q4 PFS) from the survival analysis, the SENS signature showed a trend in separating the PFS curves of “SENS+ without the 75 th percentile” (SENS+ w/o 75 th ) and SENS─ patients (mPFS values of 9.30 and 6.30 months, respectively; p = 0.560) (Fig. 2c ).
Moreover, by looking into the pattern of change over time, we noticed that the face inversion effect did not show a decreasing trend from the second test session to the end of the HDTBR (linear trend test for the effect from BR13 to BR 43: F (1,14) = 0.01, p = 0.941), standing in stark contrast to the gradual change of the BM inversion effect during the same test period (linear trend test: F (1, 11) = 32.38, p < 0.001).
Whereas the number of virions in individual tomograms was sometimes small, hence leading to a large spread, the average percentage of mature virions over several tomograms showed a clear trend.
The concentrations of Ni2+, Co2+, and Mn2+ in the feed chamber present a decreasing trend (Figs.
While the majority of the 51 proteins with a nominally significant AD-MR association on both platforms showed concordant directions of MR estimates on each platform, 5 showed opposite directions of effect between analyses with SomaScan versus Olink instruments, including PILRA (Fig. 6 ).
Additionally, HtL1 -RNAi plants show a decreasing trend in H3K4me3 modification in both the promoter and first intron regions of VRN1 in comparison with the wild type (Fig. 6e ).
In this cohort, A53T mice showed a trend to decrease in body weight, not significantly different from wt littermate controls (Supplementary Fig. 13l ).
P < 0.05 considered statistically significant, and P < 0.01 highly significant.
The highly significant observation of lower mean electron energies and lower peak heights for hits compared to nulls is consistent with electron energy loss and spectral broadening and constitutes strong evidence of radiation reaction.
Finding only nominally significant enrichments in non-neuronal cell lines suggests these may be neuron-specific drug responses.
For autism, 56 metabolites were nominally significant (aOR range 0.01–9.96), with citrate, cortisone, and imidazole lactate being the top positively associated metabolites with the highest ORs.
A clear trend emerges where lower voltage correlates with enhanced endurance, highlighting the potential reliability benefits of partial polarization.
Interestingly, we observed a clear trend where the performance was clearly stratified by the implementation of the custom-built attention layer.