Excerpts

There was a significant trend between the number of risk alleles and the magnitude of BMD loss, with patients carrying the most risk alleles having the greatest loss.

A post-hoc analysis of the ACTG A5164 study showed a trend towards a better outcome for patients presenting with PCP starting cART in the early treatment arm, although statistical significance was not reached (p>0.05).

As shown by Gatesy [17] , a strong trend toward reduced caudofemoral mass can be seen in the lineage leading to modern birds.

By comparing to a background set of 41,906 human promoters and running against known cell cycle associated transcription factor binding sites the analysis suggested a highly significant association of E2F matrices among these genes ( Table 2 ). 8 out of the 10 most significant matrix associations were all E2F binding sites, especially E2F1 ( Table 2 ); which suggests a common regulatory mechanism among these 26 genes.

Proximity prestige was also significantly negatively correlated to degree centrality in two study years, but this correlation was marginally non-significant in 2002 after sequential Bonferroni-correction (with α = 0.017).

Here, the patient showed highly significant gray matter volume decreases within portions of the left temporopolar cortex (MNI coordinates: −39, 13 −22; cluster-size of local maximum 687; T = 16.30; Z = 6.54) and a region in the border of right posterior parahippocampal and lingual cortex (MNI coordinates: 25, −55, 1; cluster-size of local maximum 700; T = 15.62; Z = 6.45).

There was a highly significant rank correlation between terpene levels at day 35 and beetle colonization in individual trees.

However, in the same study it was reported that the length of time a person smoked was significantly associated with GATA5 DNA methylation, while the former smokers showed a trend towards statistical significance of more frequent GATA5 DNA methylation [33] .

In this light, we present a pathway and network oriented GWAS analysis (PANOGA) that challenges to identify individually modest genetic effects by combining nominally significant evidence of genetic association with current knowledge of biochemical pathways, protein-protein interaction networks, and functional and genetic information of selected SNPs.

The lack of a clear trend in these results suggests that the pattern of spiking during persistent stimulation is unlikely to be the basis of a discriminatory mechanism.

For both the host gene and the HOX gene cluster case we found a highly significant correlation between the expression of the gene(s) and the miRNAs that are linked to their co-transcription.

Despite the small sample size due to the unavailability of tissue, the 1.7-fold decrease in AβPP/AβPPα in neocortex approaches statistical significance.

There is a strong trend toward increased soluble Aβ 1–40 in lysates of FXS brain samples ( Figure 6D ) while AβPP/AβPPα levels are reciprocally decreased ( Figure 6C ) in both the neocortex and hippocampus.

While vWA-containing proteins are involved in diverse processes, it is possibly significant that expression of two of these genes is in the aboral ectoderm, which will later give rise to the calicoblast layer that will be involved in secretion of the aragonite skeleton.

In addition, 10 of 14 nuclear markers in domestic pigs were detected to have a higher proportion of pairs with significant LD than in wild boars ( Table 4 ), suggesting a slight trend toward increasing LD in nuclear DNA during domestication or breeding, which is consistent with founder effects.

The pooled HRs of analysis of among women with either HER-2 positive or HER-2 negative status showed a favorable trend but no statistical difference between the 2 treatment arms.

Thus, it is highly significant to define context-specific and pathogen selective toxicity and mechanisms of action of host defense peptides or synthetic congeners thereof.

We generated a standard normal distribution to analyze the frequencies of SNPs/indels among contigs, and determine which contigs had a significantly high number of SNPs at P<0.05 (significant) and P<0.01 (highly significant).

However, the statistical parameters that can be derived from validated tracking data are highly significant and a logical way to describe the properties of large cell populations.

Since we observed an increasing trend of SIRT3 expression from 12 p.i. onwards, such result could either suggest that, in our system, SIRT3 does not render infected cells resistant to bax-mediated cell damage or, more likely, that SIRT3 facilitates the apoptotic pathway activated by CCoV-II.

In our meta-analysis, data showed a trend of higher presence of H.

In addition, although this was only a statistical trend, participants did report specific criteria for the ascription of humanness ( Figure S1d ) considerably less often in the cognitive load experiments compared to the experiments with increased cognitive load, χ 2 (1) = 3.27, p = .07.

Indeed, the results show a highly significant linear trend and demonstrate that, when interacting with a putatively naïve confederate, participants’ ratings in favor of a human interaction partner increased with increasing degrees of gaze-following.

As shown in Fig 4e – g iNOS deficiency resulted in an overall trend towards an increased percentage of tetramer+ cells among total CD8 T cells and a statistically significant increase (1.8 fold) in the absolute number of tetramer+ CD8+ T cells in the lymph node at day 3.

However, when we examined only the subset of aptamers with K d <1 nM, we observed a clear trend.