Barely Significant

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nominally significantP < 0.051.0× alphagold
Furthermore, a weighted polygenic risk score (PRS) made from the 18 SNPs common between the two datasets showed a nominally significant association ( P < 0.05) with the oral glucose tolerance test derived variables area under the curve (AUC) for insulin, AUC for insulin/AUC for glucose, insulin at 30 minutes and insulin sensitivity index ( S6 Table ).
nominally significantp<0.051.0× alphagold
There was predominantly a candidate gene approach using common alleles, which despite small sample sizes (median 93 [IQR 40–222]) with no trend to an increase over time, generated a high proportion (74.5%) of nominally significant (p<0.05) reported associations suggesting the possibility of significance-chasing bias.
showed a trendP < 0.051.0× alpha
The α-diversity and NMDS analysis of bacterial community The shannon index and richness index of the total bacterial community increased ( Fig 2A , P < 0.05) with distance from the mining area and reached a maximum at distance H5, while the simpson index showed a trend of increasing and then decreasing, and then reached a maximum at distance H2 (P < 0.05), and was higher than that of H0, although it decreased at distances H3 and H5.