Excerpts

The difference between the two groups remained highly significant even when this outlier value was excluded.

Medium effect For all traits, the medium effect was highly significant ( Table 2 and Figure 1 ), and accounted for the most important part of total variation (from ∼34% for J T 50 up to ∼80% for S ).

Although only marginally significant, this result is in line with the prediction that these genes are members of a co-adapted gene complex and illustrates that searching for main effects alone will could miss relevant determinants of complex phenotypes, although a replication of this association in an independent cohort would be needed before any conclusions can be drawn.

In the two Asian groups, the TRPV6 locus had a significant proportion of SNPs that were above the 95 th percentile of their respective Rab bins, while Europeans were nearly significant.

While the absence of the C-terminal domain for topoIIα or β had no effect on strand passage activity, the presence of the C-terminal domain from the opposite isoform had a noticeable effect with a clear trend emerging.

None of these additional SNPs showed nominally significant association to the phenotype ( Table 1b ).

Finally, when suspensory spiders are induced to run on the ground, there is a clear trend in which larger suspensory spiders tend to run much more slowly than similar-size spiders that normally move as inverted pendulums (i.e., wandering spiders).

Other markers screened in the 2 nd sample set appeared to increase/decrease the GMT level by more than 1.5-fold, but only showed a trend for association (see supplementary Table S4 ).

A dilution series illustrated a clear trend towards an increase in cell death at treatment with as little as approximately 5 to 10 pg SecTRAP, but at least 100 pg was needed to give a statistically significant increased cytotoxicity using A549 cells treated for 4 h ( Fig. 2B ).

In females, the MDM2 SNP309 locus and the age of tumor diagnosis share significant mutual information whereas, in males, the level of mutual information measured did not quite reach significance ( Figure 2 ).

Assumptions of independence are violated in AIL populations, and non-syntenic association can cause occurrence of nominally significant results to be more frequent than expected.

For asymptomatic phenotypes, prevalence (PtPF) gave lower LOD scores than parasite density (mean or maximum), although it showed highly significant heritability in Ndiop.

The correlation coefficient for consecutive turning directions, for all cells, was −0.36, with a P-value<10 −4 , a highly significant anti-correlation.

Remarkably, after 106 treatment gene expression profiles showed a clear trend toward normalization.

Nominally significant (i.e.

Furthermore, we could see a significant trend where the G residues in the first position of the G YW motifs ( Table 2 ) or the second position of R G YW motifs ( Table S3 ) were more mutated in the NBS patients, whereas no difference in targeting of the corresponding C residues in the reverse complementary motifs (WR C or WR C Y) was observed ( Table 2 and S3 ).

We observed a weak trend indicating that domain residues contacting mostly residues in the linear motif were more conserved than those contacting the context.

Parametric modulation of the functional imaging data revealed a highly significant linear increase of cortical activity in the medial frontal cortex as well as in the right temporo-parietal junction in correspondence with the increase of human-likeness of the interaction partner (computer<functional robot<anthropomorphic robot<human).

Third, the size of the patient sample may have been too small to yield significant correlations, although other studies with similar sample sizes have reported highly significant correlations between proprioceptive thresholds and disease severity in PD [11] .

A probability level of p<0.05 was considered significant, p<0.10 was considered a significant trend.

Secondly, whenever this first stage showed a significant correlation or a strong trend for an activated region (e.g. striatum and amygdala), we performed a whole-brain multiple regression analysis on the contrast image of interest using the relevant questionnaire scores (e.g.

However, a recent meta-analysis of clinical trial outcomes for the PPARγ agonist rosiglitazone found a significant increase in the risk of myocardial infarction, and a borderline significant risk of death from cardiovascular causes [4] .

These sources of uncertainty may be significant when, as in the case of rainfall, the climate variables are particularly important determinants of plant distributions [59] .

In addition, the genes in this cluster also showed a trend of down-regulation in hyphae which suggested that, unlike the 244 up-regulated genes, decreases in the mRNA levels of this cluster of genes was not specific for conidia.

One initial hypothesis was that there would be an obvious trend in the gene expression data reflecting the progressive nature of SSc in some patients.